Re: Re: Re: Re: Re: interesting
Bulldog_10 said:
Well, the other 3 (especially creatine) have been comprehensively studied and proven not to have adverse effects if taken in those doses. The label on creatine says to take 10g per serving (or whatever it is...Does the label on ALA say to take 6g per day?
You asked what the difference is between the three items listed...Well, for starters, they are TOTALLY different compounds. By your reasoning you would say that since you take 10g of creatine, you can also take 10g of winny right? What's the difference?
Remember the old days when creatine used to come in 500mg capsules? I do. I would follow the instructions (take 1-2 capsules before workout) and got nothing from it. God bless the guy who said fuck it, I'm downing a teaspon of the stuff.
WhHile the instructions on the ALA bottle say take 1 capsule per serving they are referring to its anti-oxidant effect. It's incredible fat loss properties have not yet been discovered by the masses.
It's interesting that regardless of whether it's a 100mg capsule, or 200mg or 300, the instructions are always the same, "take 1 capsule with food" 3X day.
Yes, of course the three (creatine, gluatmine and ALA) are different compounds, and while creatine has been out for a while now, and many studies have been done as to its safety at 15gms/day, ther was a long period where scare tactics ruled with regard to creatine. Recall the dehydrated wrestler in a sweat suit, in a sauna who died, and it was blamed on creatine? Remember the concerns about creatine harming your kidneys? It's a good thing people didn't stop taking creatine just because some people were concerned.
Now, with respect to ALA, there are many, many studies that have ben done on it that show it's an incredibly safe compound. Simply check pubmed. Studies have been done on its LD50, which is the lethal dose in which 50% of the subject died. That does has been calculated to be approx 30g in
one serving.
Another study showed that rats deficient in thiamin died after being administered 500mg/kg.
Here's a study that gUiLe posted as to the safety of ALA. Look at the highlighted items.
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Biological effect: Lipoic acid is observed to be biologically active and can be used clinically at dosages as low as 0.14-0.28 milligrams/kilogram of body weight (i.e., mg/kg), which would be equivalent to 10-22 mg. in an average person. Toxicology: Small animals injected with 100-200 mg/kg (i.e., the human equivalent of 7,800 - 15,500 mg.) produced depressive symptoms with tonic-clonic convulsions. In mice the convulsive dosage for 50% is 140-180 mg/kg (i.e., the human equivalent of 11,000 - 15,000 mg.). In mice, the lethal dose for 50% was 160-275 mg/kg, (i.e., the human equivalent of 13,000 - 22,000 mg.).
There were no toxic effects in mice treated by injection for 40 days with 75 mg/kg (human equivalent 6,000 mg.) nor in rats treated by injection for 60 days with 15 mg/kg (human equivalent of 1,200 mg.) nor in guinea pigs injected for 20 days at 10 mg/kg (human equivalent of 800 mg.). Lipoic acid in 0.5% solution had no undesirable effect on the mucosa, serous membrane, endothelium, or subcutaneous and muscular membranes.
"Lipoic acid is rapidly absorbed and eliminated from the organism and its accumulation is improbable." Intravenous administration of lipoic acid in high dosages in humans were "well tolerated".
So you see the amounts that we are taking 6000mg, spread out throughout the day are very safe, even if it were taken in one shot. That is not necessary. This is because, as the last highlighted sentence indicates, ALA gets in and out so fast that accumulation to lethal toxic doses is next to impossible. Now, take 20-30 grams and that overwhelms your system's ability to eliminate it from your body, and you will die.
I would never suggest that winny or anadrol be taken at 10gms/week. For one thing they are 17AA steroids which are harmful to the liver. I only believe that one should take a substance at a quantity which first is safe( plenty of studies on ALA), and second produces the desired effects.
Oh another issue with ALA is that , being a chelating agent it will leach minerals and metals out of your body. Take a multi-vitamin.
regards,
--rangerx83
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