San Diego is my favorite big city. I was born there, so that might account for the bias. Anyways, I know I'm a newbie around here, but I would really dig meeting some of you and visiting SoCal. I live a few hours North of LA, so it ain't much hassle.
Although Del Mar is nice if you have the coin to live there. Shit, with the avg. home price in SD being $500,000, it takes coin to live there too. And, that's just going to get you a 2BR 1BA place in a moderately bad neighborhood. Love the weather though. Make it La Jolla instead.