as a previous heavy user of anti-inflammatories like vioxx, motrin, and celebrex, i can tell you that your kidneys are at the most risk of trouble, followed by your stomach(ulcers), and then your liver. personally after much research and consulting with my doctor, i have permanently dicontinued their use. I have found that either a pain medicine without tylenol or ibuprofren, Ultram (non-narcotic pain med), naproxem sodium(aleve), or just plain aspirin are the safest and most effective treatments for most injuries and pains.
Just for your info, more people die every year from complications related to NSAID's than from all other medications combined, and from alchohol,illegal drug, and violent crime deaths combined.
Be Safe
mrhamilton