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POST CYCLE RECOVERY:..............RADAR'S STICKEY
- Thread starter jatca69
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:twirl ...congradulations.Public Enemy
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Re: pct pct pct pct...
OK, I know that hypothalamus senses the level of testosterone and initiates the adjustment process.
I also know that we have the Free testosterone and the BOUND testosterone from the SHBG.
My question is this: Which of the two testosterone levels does the hypothalamus sense? The free testosterone or the bound testosterone in the plasma?
I have been looking around for a while but can not find any info on this.
OK, I know that hypothalamus senses the level of testosterone and initiates the adjustment process.
I also know that we have the Free testosterone and the BOUND testosterone from the SHBG.
My question is this: Which of the two testosterone levels does the hypothalamus sense? The free testosterone or the bound testosterone in the plasma?
I have been looking around for a while but can not find any info on this.
Re: pct pct pct pct...
If I remember my biochem, free testos passes through the blood-brain barrier. Bound testos does not. Therefore, the hypothalamus would only be able to detect free testos and reacts through negative feedback. It is also suppressed when it detects high estrogen, prolactin, and progesterone.
If I remember my biochem, free testos passes through the blood-brain barrier. Bound testos does not. Therefore, the hypothalamus would only be able to detect free testos and reacts through negative feedback. It is also suppressed when it detects high estrogen, prolactin, and progesterone.
Re: pct pct pct pct...
Dr. JMW,
What are your thoughts on this study on the tamoxifen reducing the effectivness of letrozole!...
tamox can decrease plasma levels of letrozole ...
Drug and hormone interactions of aromatase inhibitors.
Dowsett M.
Academic Department of Biochemistry, The Royal Marsden NHS Trust, London, UK.
The clinical development of aromatase inhibitors has been largely confined to postmenopausal breast cancer patients and strongly guided by pharmacological data. Comparative oestrogen suppression has been helpful in circumstances in which at least one of the comparitors has caused substantially non-maximal aromatase inhibition. However, the triazole inhibitors, letrozole and anastrozole, and the steroidal inhibitor, exemestane, all cause >95% inhibition. Comparisons between these drugs therefore require more sensitive approaches such as the direct measurement of enzyme activity by isotopic means. None of these three agents has significant effects on other endocrine pathways at its clinically applied doses. Pharmacokinetic analyses of the combination of tamoxifen and letrozole have revealed that these drugs interact, resulting in letrozole concentrations approximately 35-40% lower than when letrozole is used alone.
Dr. JMW,
What are your thoughts on this study on the tamoxifen reducing the effectivness of letrozole!...
tamox can decrease plasma levels of letrozole ...
Drug and hormone interactions of aromatase inhibitors.
Dowsett M.
Academic Department of Biochemistry, The Royal Marsden NHS Trust, London, UK.
The clinical development of aromatase inhibitors has been largely confined to postmenopausal breast cancer patients and strongly guided by pharmacological data. Comparative oestrogen suppression has been helpful in circumstances in which at least one of the comparitors has caused substantially non-maximal aromatase inhibition. However, the triazole inhibitors, letrozole and anastrozole, and the steroidal inhibitor, exemestane, all cause >95% inhibition. Comparisons between these drugs therefore require more sensitive approaches such as the direct measurement of enzyme activity by isotopic means. None of these three agents has significant effects on other endocrine pathways at its clinically applied doses. Pharmacokinetic analyses of the combination of tamoxifen and letrozole have revealed that these drugs interact, resulting in letrozole concentrations approximately 35-40% lower than when letrozole is used alone.
Re: pct pct pct pct...
I believe it. Studies on drug interactions are important. With regards to steroid athletes, I can't think of any reason one would be using both letrozole and tamoxifen in any cycle. I do not ever recommend the use of an aromatase inhibitor (like letrozole) during PCT (when using nolvadex and/or clomid) . Some "experts" do.
Some "experts" do an aromatizing AAS cycle and choose letrozole as their anti-e. Subsequently, they develop pre-gyno or full-blown gyno. So, they just add some megadoses of nolvadex. What they are doing is reducing the effectiveness of the letrozole. What they probably should do is reduce the amount of aromatizing AAS they are using and/or switch to aromasin or arimidex.
I believe it. Studies on drug interactions are important. With regards to steroid athletes, I can't think of any reason one would be using both letrozole and tamoxifen in any cycle. I do not ever recommend the use of an aromatase inhibitor (like letrozole) during PCT (when using nolvadex and/or clomid) . Some "experts" do.
Some "experts" do an aromatizing AAS cycle and choose letrozole as their anti-e. Subsequently, they develop pre-gyno or full-blown gyno. So, they just add some megadoses of nolvadex. What they are doing is reducing the effectiveness of the letrozole. What they probably should do is reduce the amount of aromatizing AAS they are using and/or switch to aromasin or arimidex.
wutangnomo
New member
Re: pct pct pct pct...
DrJMW what are your thoughts on proviron? Do you see a place for it during a cycle or after?
DrJMW what are your thoughts on proviron? Do you see a place for it during a cycle or after?
Re: pct pct pct pct...
So you think maybe it might be better to go with arimidex/nolvadex instead of femara/nolva? I am prone to gyno (had it cut once already) and estrogen related sides so I really want to figure this out! Or do you think it would be best to just run femara at the right dosage and you shouldn't have to worry about gyno/nolva use?
DrJMW said:
So you think maybe it might be better to go with arimidex/nolvadex instead of femara/nolva? I am prone to gyno (had it cut once already) and estrogen related sides so I really want to figure this out! Or do you think it would be best to just run femara at the right dosage and you shouldn't have to worry about gyno/nolva use?
Re: pct pct pct pct...
Proviron, in my opinion, has no place in the modern cycling of steroid athletes. First, it is not FDA-approved, and therefore, illegal to possess and use in the USA. Second, aromasin and arimidex are superior anti-e's and readily available.
For someone gyno-prone, you have several options: 1) Avoid aromatizing AAS; the problem here is if switching to a androlone, then you have prolactin (instead of estrogen) to worry about. Those prone to estrogenic gyno also seem prone to prolactin gyno. 2) Lower your dosing of aromatizing AAS to the point where arimidex or (aromasin or femara) work for you; 3) Keep DHT gel handy if you develop "pre-gyno" while using aromatizing AAS and arimidex (or Femara or Aromasin). You need to tweak your cycles until you get it right. So, you have three options. Pick one and make the adjustments as needed. I have one client who is very susceptible to gyno. He uses low-dose test enanthate (100mg weekly), arimidex, and he keeps DHT gel at hand. His testos levels are near the top of normal and he is doing well avoiding gyno. Hope this helps.
Proviron, in my opinion, has no place in the modern cycling of steroid athletes. First, it is not FDA-approved, and therefore, illegal to possess and use in the USA. Second, aromasin and arimidex are superior anti-e's and readily available.
For someone gyno-prone, you have several options: 1) Avoid aromatizing AAS; the problem here is if switching to a androlone, then you have prolactin (instead of estrogen) to worry about. Those prone to estrogenic gyno also seem prone to prolactin gyno. 2) Lower your dosing of aromatizing AAS to the point where arimidex or (aromasin or femara) work for you; 3) Keep DHT gel handy if you develop "pre-gyno" while using aromatizing AAS and arimidex (or Femara or Aromasin). You need to tweak your cycles until you get it right. So, you have three options. Pick one and make the adjustments as needed. I have one client who is very susceptible to gyno. He uses low-dose test enanthate (100mg weekly), arimidex, and he keeps DHT gel at hand. His testos levels are near the top of normal and he is doing well avoiding gyno. Hope this helps.
wutangnomo
New member
Interesting. So doc you don't think proviron is a good drug to free up bound test? Putting legality issues aside, do you not think proviron has any usefulness when it comes to improving libido?
