Guvna said:
I believe you have a few things mixed up.
HDL or high density lipoprotein is the cholesterol carried by the alpha lipoproteins. A high level of HDL is an indication of a healthy metabolic system if there is no sign of liver disease or intoxication. The two mechanisms that explain how HDL offers protection against chronic heart disease are that HDL inhibits cellular uptake of LDL and serves as a carrier that removes cholesterol from the peripheral tissues and transports it back to the liver for catabolism and excretion
The most commonly used markers of hepatocyte injury are aspartate aminotransferase (AST/SGOT) and alanine aminotransferase (ALT/SGPT). While ALT is cytosolic, AST has both cytosolic and mitochondrial forms. Also, another important marker is Gamma Glutamyl Transpeptidase (GGT)
ALT
The enzyme appears in liver cells, with lesser amounts in the kidneys, heart, and skeletal muscles, and is a relatively specific indicator of acute liver cell damage. When such damage occurs, ALT is released from the liver cells into the bloodstream, often before jaundice appears, resulting in abnormally high serum levels that may not return to normal for days or weeks. The purpose of this blood serum test is to help detect and evaluate treatment of acute hepatic disease, especially hepatitis, and cirrhosis without jaundice
AST
The purpose of this blood test is to detect a recent myocardial infarction (heart attack) and to aid detection and differential diagnosis of acute hepatic disease and to monitor patient progress and prognosis in cardiac and hepatic diseases. AST levels fluctuate in response to the extent of cellular necrosis (cell death) and therefore may be temporarily and minimally elevated early in the disease process, and extremely elevated during the most acute phase. Depending on when the initial sample was drawn, AST levels can rise indicating increasing disease severity and tissue damage or fall indicating disease resolution and tissue repair. Thus, the relative change in AST values serves as a reliable monitoring mechanism.
GGT
This is involved in the transport of amino acids and peptides into cells as well as glutithione metabolism, Gamma Glutamyl Transpeptidase is mainly found in liver cells and as such is extremely sensitive to alcohol use. Elevated levels may be found in liver disease, alcoholism, bileduct obstruction, cholangitis, drug abuse, and in some cases excessive magnesium ingestion.
Jenetic