I think we still don't know enough, and everyone is different and the compounds each of us take and what they do to us is also different.
The guys that seem to be *healthy*, old, happy, and still fit are the guys that were/are on moderate/therapeutic dosages and/or run HGH at a reasonable dose.
I ran a cycle that was 6-8 months long, the last 6 weeks I was on TRT dose of prop 50mg Mon/Wed/Fri..during the cycle I started at 500mg test and 300mg ace, I got all the way up to 100mg ED of ace and 1000mg a week of enan.. I have to say the best part of the cycle was the last few weeks on just low dose prop and hcg.. I think it was a combination of things, the smaller injections so pain was none, i was having libido problems and it didn't worry me so I felt focused and satisfied slightly worried.. My progress kept going those last 6 weeks, and I think I looked my best.. At this moment a year later, I wish I would have never got off my 50mg m/w/f.. Going to see the doc today..
In the end problems with cholesterol affect a lot of organs and unfortunately some of the more important ones..liver, kidneys, pancreas, heart, even our arteries.. There is no hiding AAS affects the way our bodies process lipids.
Edit: the reason i did the low dose prop at the end was due to the length of time and dosage i was on with the ace.. I was having some serious fina flop when I went from 700mg a week to 300mg for a week and then when I ran out the following week it was downhill for my sex life.. hcg, prop, dost, cialis&viagra let my summer happen..