when in doubt, look to science. its pretty easy to figure out that 99.9% of humans will not be able to replicate the muscle building environment on a daily basis for 365 days and add weight, lean muscle weight, at a consistent upward progress. heres a real basic look at what goes into making muscle. with all the processes going on in the body on a daily, weekly, monthly basis, there is no way the body will simply downregulate all other functions to focus on muscle growth only, and that is what would have to happen to add 35 pounds of muscle in a year.
Muscle Building
How many calories do you think are required to build a pound of muscle? Amazingly, to build a pound of muscle tissue requires over 45,000 calories. How can that be, you ask? After all, a pound of muscle at about 20% protein comes out to be 90 grams of protein. That muscle is also comprised of about 13 grams of lipids, 4 to 5 grams of glycogen, and several millimoles of ATP and creatine phosphate. The rest is water. If you break down that pound of muscle to consume it as calories, it works out to 4 calories per gram of protein and glycogen, plus 9 calories per gram of lipid, plus a few hundred calories for the ATP and creatine phosphate --- so --- we have a total energy value stored in that muscle of 750 calories. “It doesn’t add up,” you say. “If a pound of muscle can only be catabolized to yield 750 calories, how can it be claimed that nearly 50,000 calories went into building that muscle?” The key is in understanding that anabolism and catabolism are not reversibly equivalent.
Protein anabolism has an almost unbelievably high energy cost. Building a pound of muscle is analogous in many ways to building the Great Pyramids of ancient Egypt. Those pyramids were not carved out of rock that was already there, they were assembled from countless smaller rocks hauled into place and lifted into position by literally millions of man hours of energy output. So it is with building a muscle. Muscle protein is synthesized from the assembling of individual amino acids within each of the muscle cells. Every single peptide bond in every one of the protein molecules requires the expenditure of energy. The energy equivalent of three moles of high energy phosphate bonds is required for every mole of peptide bonds.
Now, consider that muscle proteins consist of peptide chains used to build light myosin, heavy myosin, actin, and collagen. The average molecular weight of these various proteins is about 200,000, yielding about 2000 peptide bonds per molecule. Since each of those peptide bonds requires degradation of 3 phosphate bonds, and each high energy phosphate bond of ATP or GTP yields about 8000 calories per mole, we can estimate the energy cost of making one mole of protein at about 3 X 8000 X 2000 = 48,000,000 calories per mole of protein. This works out to be about 220 calories per gram of protein. Now, multiplying this 220 calories per gram times the 90 grams of protein in a pound of muscle we come up with something close to 20,000 calories of ATP and GTP to synthesize the protein in one pound of muscle.
However, the reality of the situation is a little more complex. The efficiency of energy transfer in the production of ATP from glucose is only about 44%. This means that to supply the muscle building process with the extra 20,000 calories of ATP and GTP, you must consume a total of more than 45,000 extra food calories. When we add in the calories stored in the lipids and glycogen and ATP and creatine phosphate of the muscle, plus the calories to synthesize those substances, we get a grand total of approximately 47,000 calories.
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