Why Does Anyone Use Nolvadex Anymore???

[needtogetaas]

I am going to come back to this post later when I have more time. I have come to realise that there is no official Post Cycle Therapy or cookie cutter once size fits all pct for all cycles. Pct,pree pct,bridging for all different cycles is way more then something one cookie cutter official Post Cycle Therapy can cover.

So I will cover many different cycles,length of cycles,compounds used,what can be used on cycle,what can be used during cycle,what can be used for pct, methods of pre pct, methods of bridging and more. I think the members of ef diserve much more then a cookie cutter pct.

In the mean time if you need pct advice just send me a pm and I would be more then happy to help you.


First off I would like to say if you cant sit through something like this and read the whole thing. Then you really have no business taking these kinds od drugs in the first place. You also have no business making a comment on this thread ether. Thanks.

What Is Nolvadex/Tamoxifen?

Tamoxifen is considered as the antagonist of the estrogen receptor which again is primarily present in the breast tissue of the human body. It is interesting to note that certain breast cancer cells require that the estrogen levels need to grow with passing time. Ideally, Tamoxifen has been used as the standard endocrine for the treatment of early breast cancer patients. It is therefore used as an anti estrogen therapy and it is mainly given to postmenopausal women. The role of an estrogen is to bind as well as activate the estrogen receptors that are present in the breast cells of a human body. The role of Tamoxifen is to stop estrogen to bind with the receptor. Although it is metabolized into compounds that aid in the binding of estrogen receptors, Tamoxifen does not allow the estrogen receptors to get activated in the breast cells of the human body. Hence, the growth of breast cancer cells can be stopped by making use of this compound. Nonetheless, results vary from person to person and the use of Tamoxifen cannot be deduced as a permanent cure for breast cancer patients.

It is ideally a drug which is taken orally in the form of an edible tablet and it is known to interfere with the activity of the estrogen levels present in the breast tissue. It has been studied that unless the estrogen levels in the human body are kept under strict control, they can lead to breast cancer. Tamoxifen has primarily been used for the past 30 years for treating patients suffering from breast cancer. It has also been administered to patients who are in their early stages of breast cancer. Even patients whose breast cancer has spread to various parts of the body have been known to use Tamoxifen on a regular basis. It has been stated that this drug has the ability to stop cancer cells from spreading within the human body but ironically there is no substantial study which clearly backs this statement with the help of substantial proof. Nonetheless, owing to the hype that it has received via media, people who are having breast cancer or those women who run the risk of developing breast cancer have been known to take this medicine on a regular basis. Interestingly, it has also been seen that women who are suffering from ductul carcinoma in stu, which in turn is similar to invasive breast cancer, have also been known to administer this medicine on a regular basis.

In the past 20 years steroid users have been using nolvadex for a number of reasons. To ether help reduce bloat or gyno problems during a cycle or after a cycle to help recovery natural test production. In men, tamoxifen "nolvaldex" is sometimes used by steroid-taking, weight-training athletes.An alternative and highly similar compound is clomiphene citrate "clomid". These drugs are used as anti-estrogen therapy. In this regard, the drug is used for three purposes. The first purpose, is to reduce the effect of circulating estrogens even if Tamoxifen itself increase the circulating level of estrogens since they are not bound to the estrogen receptors. Abnormally high levels of estrogen in men, can be caused by taking highly aromatizing anabolic steroids e.g. Dianabol, Anadrol or Testosterone. In dosing with a dosing with 20 mg of Novaldex (Tamoxifen) for the duration of a steroid cycle, a reduction in water retention can be achieved. This prevents large fluctuations in water weight within the muscle.

Using Tamoxifen for the duration of a steroid cycle may or may not promote a preferable outcome for a weight training athlete, as the temporary increase in water weight within the muscle increases strength and allows larger weights to be used for the duration of the steroid cycle. Said water will dissipate once usage of steroids has ceased, and a dramatic loss in weight can be observed. Tamoxifen is also used to prevent estrogen related gynecomastia, resulting from elevated estrogenic levels. It can be taken as a preventative measure in small doses, or used at the onset of any symptoms e.g. nipple soreness/sensitivity. In the latter case, dosing reverses the affliction

However it Is now well known that well taking nolvadex serum level estrogen raises and yet another drug must be taken with it during cycle,during pct,or after pct to prevent estrogen rebound. (how retarded). Studies have of course shown the its use can cause a rise in lh and test production but at what cost? Many other factors must be taken into account.

All this is happening in complete ignorance as they are not aware that this medicine has certain side effects that can prove fatal in the longer run. At the same time robbing ones self of a better pct and cycle from using drugs like this.
Though I do feel its "ok" to use them "if you must" but use as little as you can and use support/pct sups to help alleviate the side effects and bad feelings one gets from these harsh drugs.

Where Was This drug Discovered?

Interestingly, this drug was discovered by AstraZeneca Pharmaceuticals which were earliest known as ICI pharmaceuticals. It is now sold under various trade names such as Nolvadex, Valodex and Istubal. Although it is sold under various names, it is primarily known and popularly termed as Tamoxifen. Although this drug is widely used in treating breast cancer patients, it also has adverse side effects which very few people are actually aware off.

Once praised for its benefits in preventing breast cancer recurrence, the lucrative pharmaceutical drug tamoxifen is now implicated in causing dangerous side-effects, including other types of cancers.

In the early 1970's, a shameful chapter closed on the widespread use of a known carcinogenic and endocrine-disrupting drug called DES (diethylstilboestrol), the first synthetic, non-steroidal estrogen drug. Against the advice of its creator, Sir Charles Dodd, between four and six million American and European women and 10,000 Australian women innocently used DES for the prevention of miscarriage and pregnancy complications.

In addition, DES became a popular though unproven drug for a variety of other conditions. It was used for the suppression of lactation, the treatment of acne, the treatment of certain types of breast and prostatic cancer, and as an inhibitor of growth in young girls, an estrogen replacement in menopause and a "morning after" pill.

It would take 30 years to accept what laboratory tests had indicated as early as 1938 — that DES was a highly dangerous and harmful drug. It was reported that, 20 years after taking DES, mothers had a 40 to 50 per cent greater risk of breast cancer than non-exposed mothers. In addition, the children of DES mothers showed a high incidence of reproductive abnormalities, miscarriages, vaginal cancer, testicular cancer, sterility and immune dysfunction. In fact, it is feared that repercussions of this drug will be felt for generations to come.

The irony of this entire debacle is that the medical establishment finally acknowledged that DES was useless in preventing miscarriages. Thus, DES, another disastrous experiment on women, was added to the long list of major medical blunders.

Out of this early research, a new drug appeared on the horizon which would be soon be heralded as a shining star in the war against the growing epidemic of breast cancer. In the late 1960's the pharmaceutical industry developed a drug called "tamoxifen". As a synthetic, non-steroidal compound with hormone-like effects (many of which are poorly understood), tamoxifen has a similar structure to DES. In fact, it was observed that tamoxifen caused the same abnormal changes seen in cells of women taking estradiol and DES. This similarity raised alarm bells for some.

Pierre Blais, well known as a drug researcher who was ejected from Canada's health protection bureaucracy when he spoke out about silicone breast implants, describes the story of tamoxifen as "the story of modern drug design which produces garbage drugs". He says, "Good drug design ceased, unfortunately, in the 1930s." Tamoxifen, Blais asserts, "...is a garbage drug that made it to the top of the scrap heap. It is a DES in the making."

Blais's dire predictions were ignored with the promise of a potential drug treatment for breast cancer. Tamoxifen was first approved by the US Food and Drug Administration (FDA) for use as a birth-control pill; however, it proved to induce rather than inhibit ovulation.(just goes to show how retarded they truly are) Although tamoxifen didn't work as a contraceptive, it was found to lower mammary cancer rates in animals. Animal studies showed that tamoxifen prevented estrogen from binding to receptor sites on breast tissue cells. Tamoxifen also reduced the incidence of breast cancer in rodents after administration of a breast-carcinogenic substance. This discovery provided the impetus to study its effects in treating human breast cancer.

Estrogen is the common link between most breast cancer risk factors, i.e., genetic, reproductive, dietary, lifestyle and environmental. It both stimulates the division of breast cells (healthy as well as cancerous) and, especially in its 'bad' form, increases the risk of breast cancer. Thus, hormonal drugs such as tamoxifen that block the effects of estrogen on the breast were expected to reduce the risk of breast cancer recurring in women treated for breast cancer.

Tamoxifen acts as a weak estrogen by competing for estrogen receptors much as phyto-estrogens do(I want you to keep this word PHYTO ESTROGENS IN MIND WE WILL COVER IT AGAIN LATER). Like phyto-estrogens, tamoxifen has mild estrogenic properties but is considered an anti-estrogen since it inhibits the activity of regular estrogens. More accurately, tamoxifen is an estrogen-blocker(Not a estrogen reducer)
HORMONAL EFFECTS OF TAMOXIFEN IN OLIGOSPERMIC MEN -- WILLIS et al. 73 (1): 171 -- Journal of Endocrinology

Yes the test shows over time that both lh and androgins were raised, but at the same time (serum level estrogen was tripled)and thus the reason many experence rebound gyno after its use.

Tamoxifen fights breast cancer by competing with estrogen for space on estrogen receptors in the tumor tissue. Every tamoxifen molecule that hooks onto an estrogen receptor prevents an estrogen molecule from linking up at the same site. Without a steady supply of estrogen, cells in an estrogen-receptor-positive (ER+) tumor do not thrive and the tumor's ability to spread is reduced.

However, tamoxifen exhibited two conflicting characteristics. It could act either as an anti-estrogen or as an estrogen. Therefore, while tamoxifen is anti-estrogenic to the breast, it also acts as an estrogen to the uterus and, to a lesser extent, the heart, blood vessels and bone. Moreover tamoxifen also acts as an estrogen in the liver thus causing the lowering of IGF-1
In This Issue -- 82 (21): 1661 -- JNCI Journal of the National Cancer Institute
http://cancerres.aacrjournals.org/cgi/reprint/49/7/1882.pdf
Effect of low dose tamoxifen on the insulin-like growth factor system in healthy women
Comparison of Tamoxifen and Testosterone Propionate in Male Rats: Differential Prevention of Orchidectomy Effects on Sex Organs, Bone Mass, Growth, and the Growth Hormone-IGF-I Axis -- Fitts et al. 25 (4): 523 -- Journal of Andrology

For people suffering from breast cancer I guess this would be a good thing. Since Lowering IGF would reduce the growth of everything. However this is not one any of the people using nolva for pct or on cycle use want now is it?

So, although it initially showed the tendency to counter breast cancer recurrence, it would soon be revealed that it also promoted particularly aggressive uterine and liver cancers, caused fatal blood clots and interfered with many other functions.

Doctors, however, were quick to jump on the tamoxifen bandwagon, turning a blind eye to its more injurious tendencies. Starting in the 1970's oncologists began using tamoxifen to treat women with cancer, often in combination with other drugs, radiation or surgery such as lumpectomy and mastectomy, with modest success. Like DES, tamoxifen's benefits were then extended for use as a preventive against osteoporosis and heart disease.

Today, doctors are treating about one million American breast cancer patients with tamoxifen, about 20 per cent of them for more than five years. As studies published in the New England Journal of Medicine in 1989 and the Journal of the National Cancer Institute in 1992 showed, women with breast cancer who took tamoxifen reduced their chances of developing cancer in the other breast (contralateral cancer) by about 30 to 50 per cent. These findings would later be challenged.

Tamoxifen is now recommended for all pre-menopausal women with hormone-positive cancers, as well as for most postmenopausal women with breast cancer and/or a growing number of women with hormone-negative cancers. Tamoxifen is currently used by more women with breast cancer than any other drug.

Tamoxifen (brand name Nolvadex) is now the most widely prescribed cancer medication in the world. It generated revenues of US $265 million in 1992. By 1995, worldwide sales of Nolvadex reached $400 million. (7) And at AUD $90 for one month's supply, it doesn't come cheap (the Australian Pharmaceutical Benefits Scheme covers $70).
Global sales of tamoxifen in 2001 were $1,024 million.[54] Since the expiration of the patent in 2002, it is now widely available as a generic drug around the world. Barr Labs Inc had challenged the patent (which in 1992 was ruled unenforcable) but later came to an agreement with Zeneca to licence the patent and sell tamoxifen at close to Zeneca's price.[55] As of 2004, tamoxifen was the world's largest selling hormonal drug on record and off record may be the number 1 selling drug in word of all time to date. So we are truly talking about billions in revenue world wide for drug companies,sources,ug's and more. Money is at the root of this drug and why its so heavily pushed on all forums by everyone. Its cheap to make and it brings in billions plain and simple.

These numbers are nothing compared to what this drug now makes for the drug companies,sources.ug's selling it. So you can bet your life they will make sure every test and study in the world is published to make sure its seen in a good light. This not even including its "off label use" Ie all us men using it for on cycle and pct. The use of the drug for this reason triples its sales and you can just emagen the amount of money its making. You do the math my friends!. At this very moment 500000000 sources and people with monitary ties to this drug are out there pushing like crazy to make sure you and everyone else keeps its use for pct alive. This is the #1 reason why we have not given up on this years ago.

Tamoxifen was developed by UK-based Imperial Chemical Industries (ICI), one of the world's largest multinational chemical corporations. Zeneca, an ICI subsidiary, is responsible for manufacturing and marketing the hormone and is now the world's largest cancer-drug company.
CARCINOGENENIC EFFECTS
It wasn't long before laboratory studies showed that tamoxifen acted as a carcinogen. It has been found that tamoxifen binds tightly and irreversibly to DNA, the genetic blueprint of a cell, causing a cancerous mutation to take place. Even Australia's conservative National Health and Medical Research Council (NHMRC) warned that no amount of tamoxifen is safe when it comes to carcinogenic effects.

In California there is a law called "Proposition 65" that requires the state to publish and maintain a list of all known carcinogens. In May 1995, the state's Carcinogen Identification Committee voted unanimously to add tamoxifen to its list.

When research is done on anti-cancer drugs (such as SERMs), the aim is to find a drug that prolongs life, with the least amount of acute side-effects. In other words, the goal isn’t so much about finding a cure, as it is finding something that can alleviate the symptoms and/or prolong life.

When it comes to steroid users so many are willing to forgo any and everything to get the one simple effect they desire (recovery). The popularity of these drugs stems from the popular advice to use these drugs for everything from testosterone recovery.bitch tits,make your dick grow bigger, increase the amount of jiz you drop on a girls face, and everything in between. Advice on its use is handed out like candy and everyones got a sweat tooth for quick advice. Of course many "vets and so called know it alls" defend it to the death and it can do no wrong. Mainly do to not wanting to be wrong,habit,they got money involved with it, or just for the sake of argument.

“Its FDA approved for cancer treatment. It must be safe!”

It’s wrong to assume that an “FDA approved” drug has a proven safety profile. The FDA has continually issued stronger health warnings for tamoxifen over the years. For instance, in 1994 the FDA demanded that the tamoxifen manufacturer Zeneca (an ICI sub-division), issue warning letters to health care practitioners about the increased risk of endometrial and gastro-intestinal cancers with tamoxifen use. Zeneca also reported adverse effects similar to those seen with DES, such as reproductive abnormalities in the animals whose mothers received tamoxifen. (remember, DES was the original synthetic estrogen, and also an analog to tamoxifen)

A number of cancer researchers have pointed out the health risks too, such as Elwood et al (6) -

“[Tamoxifen], therefore, is not appropriate for use in the general population because of the known increased risk of endometrial cancer”


What Are Side Effects Of Temoxifen

You Can Get Blood Clots!

Have you any idea that a regular dosage of Tamoxifen can actually increase the chances of blood clots? Well, this is a true fact and can be fatal for those who are using this drug to get rid or avoid the chance of getting Gyno on cycle and or for pct. According to recent medical studies, it has been noticed that people who have been using Tamoxifen on a regular basis have had a substantial increase in terms of their blood clots. Hence, as compared to those people who are not using this drug, their chances of getting blood clots is relatively higher.

A blood clot can be defined as an internal body mechanism by which the cut can be stopped from bleeding excessively. The proteins present in your blood work along with the platelets and in a bid to form a clot. This is also termed as coagulation. In the event of an injury, this can prove to be really very effective as it would stop the flow of blood from your wound and thus save your life. Nonetheless, if the blood clots while it is moving through your body, it can prove fatal. This is also termed as hyper coagulation and it can prove very dangerous for the concerned individual. Tamoxifen has been known to cause hyper coagulation and hence, it needs to be taken under strict medical supervision.

When the study was conducted, it was ascertained that a relatively large number of people developed this conditions and although not many people using this drug were actually studied, those that were using it regularly, were in a shock to find out that it also led to blood clots.

Hence, although this drug is helpful to a certain extent, we need to also see that the extent of damage it can do to our body in terms of hazardous blood clots are much more and hence, you as a steroid user need to exercise caution and spend some quality time researching on this so called ‘wonder-drug’ before making it an eminent part of your daily routine and or pct.

One of the main reasons why a blood clot is considered dangerous is because this drug causes a clot inside the blood vessel which in turn is known as thrombus. What happens is that at times this blood clot can travel through your blood streams and get pushed into your lungs. When this happens, you can be rest assured that your life is in acute danger as this condition is life threatening. This condition is also known as pulmonary embolus. Similarly, a clot this clot can also block the blood vessels in the brain and this in turn may lead to a stroke. When this blood clot clocks the blood vessels of your heart, it stops the blood from rushing to your heart area thereby reducing the oxygen supply to that area. This in turn leads to cardiac arrest.

All the above mentioned conditions arising from blood clots, which in turn are caused from a regular intake of Tamoxifen, can prove to be life threatening for the concerned individual. Hence, even before you decide to take this medication on a regular basis, you need to exercise caution and be prepared to face the ill effects of this so called ‘wonder-drug’.



Increased susceptibility to gyno -

Tamoxifen is often used to combat gyno during cycle when “flare ups” occur. While tamoxifen may provide immediate inhibition of proliferation, and serve as valuable tool, it can actually increase future susceptibility to gyno.

This is caused by tamoxifen’s ability to up-regulate the progesterone receptor. (54-56) This can dramatically increase the chances of developing gyno in future cycles when utilizing progestin based anabolics such as Nandrolone (Deca) or Trenbolone (or any pro-hormone acting upon the progesterone receptor).

It is interesting to speculate. Is tamoxifen use directly related to the increased gyno occurrences seen with modern day steroid users?


You Can Develop Cataract!

Cataract can be defined as a thin white layer of membrane which blocks the passing light to the retina thereby clouding your vision. Although it is relatively painless, it does cloud your vision and can even blind you if it is not removed through the means of a surgical procedure. The retina is ideally a nerve layer which is located at the back of the eye socket and its main purpose is to direct the light which is entering the eye via the means of electromagnetic signals to the brain. Once the brain receives these nerve signals, it is passed on to the nervous system, after which you can transform your vision into clear moving pictures. If this thin layer of membrane is blocked owing to any reason, you would have problems with your vision.

While aging is looked on as the major cause behind cataract, it has recently been noticed that patients using Tamoxifen have been identified as ones susceptible to cataract on a regular basis. people who are aging and using this drug on a regular basis are on a higher risk of contracting cataract as compared to those who are not using Tamoxifen. The other eye problems that can be faced by individuals include scarring of the corneal area and abrupt retinal changes.

In case you are using this drug regularly and you have a cloudy, fuzzy or foggy vision, you need to get your eyesight checked with immediate effect. In case you are unable to withstand the glare of lamps and are unable to catch a glimpse of the morning sun, then again you need to get your eyes checked. This is so because, Temoxifen has a natural tendency to obstruct the normal eye vision and if you do suffer from this symptom, you may not be able to drive at night as the headlamps of the opposing vehicle may blind you momentarily.


In order to get rid of cataract that has been developed owing to a continuous intake of Temoxifen, you may need to undergo a corrective surgery. In case you want to delay a surgical procedure, you may want to light up your room with plenty of tubes and bulbs and keep your eyeglass up to date with the latest prescription. Ideally, the only known cure for cataract that has been a resultant of Temoxifen is a surgical procedure.

If you would like to avoid this problem, you would have to seek an alternative to Temoxifen at the earliest given opportunity.



Libido reduction & erectile dysfunction
Erectile dysfunction ow libido, and general impotence are typical complaints from men recently discontinuing steroids or HRT therapy, which is often combated by Clomid or Nolvadex, paradoxically so.

Regardless of any positive effects on fertility or testosterone levels, Clomid and Nolvadex use is highly correlated with erectile dysfunction, libido suppression, and even emotional disorders Research with male breast cancer patients has also reported decreased libido, and thrombosis associated with tamoxifen use. he thrombotic effect (blood vessel clogging) could explain the mechanism by which SERMs may inhibit erectile function, by reducing circulation to erectile tissue (as discussed before)


Nolva/clomid both raise shbg.
This is something I do not see a lot of people disusing so I I wanted to make it well know. Just do a web search on TAMOXIFEN,clomid or nolva raises shbg or any variation and you will get all the studies and prof you need.
Trait Anxiety and Tamoxifen Effects on Bone Mineral Density and Sex Hormone- Binding Globulin -- Cameron et al. 64 (4): 612 -- Psychosomatic Medicine
iHOP - Information Hyperlinked over Proteins [ SHBG ]
Sex Hormone Binding Globulin in Clinical Perspective; Acta Obstetricia et Gynecologica Scandinavica - 66(3)ages 255-262 - Informa Healthcare
Wiley InterScience :: Session Cookies

2. Nolva lowers Igf-1 Again just a simple search on (TAMOXIFEN or nolva lowers IGF 1 and walla you got all the prof you need.

In This Issue -- 82 (21): 1661 -- JNCI Journal of the National Cancer Institute
http://cancerres.aacrjournals.org/cgi/reprint/49/7/1882.pdf
Effect of low dose tamoxifen on the insulin-like growth factor system in healthy women
Comparison of Tamoxifen and Testosterone Propionate in Male Rats: Differential Prevention of Orchidectomy Effects on Sex Organs, Bone Mass, Growth, and the Growth Hormone-IGF-I Axis -- Fitts et al. 25 (4): 523 -- Journal of Andrology


They can cause Major triglyceride and glucose problems and even to the point of Severe hypertriglyceridemia or also Pancreatitis

Severe hypertriglyceridemia caused by tamoxifen-tr... [Endocr J. 1997] - PubMed result
Tamoxifen-induced hypertriglyceridemia in association with diabetes mellitus - EM|consulte
SpringerLink - Journal Article
Capecitabine-Induced Severe Hypertriglyceridemia: Report of Two Cases -- Kurt et al. 40 (2): 328 -- The Annals of Pharmacotherapy
Elsevier: Article Locator
Estrogen and Triglycerides
http://annonc.oxfordjournals.org/cgi/reprint/11/8/1067.pdf
WikiGenes - Hypertriglyceridemia


A word on clomiphene (Clomid) –

Clomiphene (Clomid) consists of two stereoisomers which possess radically different pharmacodynamics. Zuclomiphene has predominantly estrogenic effects and slow clearance while the enclomiphene isomer has predominately anti-estrogenic effects and quick clearance. his creates a divergent effects between estrogen blockage and estrogen stimulation and an acute imbalance once Clomid administration is discontinued. Bodybuilders will often complain of “estrogenic rebound” after stopping Clomid, which could be attributed to the lingering estrogenic isomer zuclomiphene as the anti-estrogenic enclomiphene has long cleared the system. (Recently, enclomiphene has been isolated by the pharmaceutical company Repros, for use in Androxal™.)

For all intents and purposes, tamoxifen is a superior SERM, simply for the fact that tamoxifen provides a purely anti-estrogenic isomer, whereas Clomid provides a mix of anti and pro estrogenic effects.

In regards to the health consequences about to be listed, it can be safely assumed that Clomid will share similar detrimental effects as tamoxifen, since it shares the same triphenylethylene backbone and carcinogenic tendencies.


One of the main reasons why people make use of Clomid is for the purpose of recovering their bodies after a steroid cycle In simple words, this drug is mainly used in the form of post cycle therapy. Clomid has the actual potential to stimulate the production of hypothalamus which in turn would release a particular kind of hormone called gonadotrophic hormones. This hormone has the natural ability to allow the human testicles to secrete testosterone, which in turn would bring the depleting levels of testosterone in the body to its permissible levels. When this is achieved, the human body would stop losing its muscle mass in a natural way. Reacovery of test production is the gaols at any cost is the common thought.


Its a known fact that both clomid and nolvadex cause some really messed up mood swings.
Clomid/nolva have been known to cause severe mood swings in users and it has apparently been noticed that anyone who has been making use of Clomid/nolva have suffered from such side effects on a regular basis. Many users have categorically complained that the use of Clomid has been considered as the worst side effect that they have suffered so far. A few features of mood swings may include a change in the usual behaviour, tearful behaviour, excessive depression, anxiety and extremely sensitive in nature. Stop acting like you don't know what I am talking about. We all know its true.


Liver cancer -

Originally, tamoxifen was accepted as being non-toxic to the human liver upon finding that tamoxifen did not cause noticeable liver damage (DNA adducts) during short-term test tube studies with human liver cells.

However, it became apparent that test tube research was largely flawed due to the low rate of metabolism in such a superficial environment. It was soon discovered that the hepatotoxic effects from tamoxifen stem from the metabolism and buildup of the a-hydroxytamoxifen and N-desmethyltamoxifen metabolites, which would only appear in an in vivo environment. Surely enough, the results from the original rat studies showing dramatic carcinogenic effects on the liver, soon correlated with human data when researchers found the same type of liver DNA adducts in tamoxifen patients.

More recent human research has reported tamoxifen treated women to have 3x the risk of developing fatty liver disease, which occurs as soon as 3 months into therapy at only 20mg/day. In some cases, the disease lasts up to 3 years, despite cessation of tamoxifen therapy. Five and ten year follow-ups with patients on long term tamoxifen therapy show cases of deadly hepatocellular carcinoma.

In 2002, a bizarre study examined the use of tamoxifen for hepatocellular carcinoma treatment in humans. It was assumed that since tamoxifen could inhibit proliferation of breast cancer, it could offer the same benefit for liver cancer. The devastating results could not have been more indicative of tamoxifen’s hepatotoxic nature, as the tamoxifen treatment significantly increased the rate of death, compared to the group not receiving tamoxifen.

Finally, in a case study reviewing tamoxifen induced liver disease; D.F Moffat et al made a profound statement –

“Hepatocellular carcinoma in tamoxifen treated patients may be under-reported since there may be reluctance to biopsy liver tumours which are assumed to be secondary carcinoma of the breast.” In other words, it appears that liver carcinomas from a large number of breast cancer patients on tamoxifen therapy have been misdiagnosed as an infection from the breast cancer itself.

Although tamoxifen induced liver cancer may take years to manifest in a healthy male, its damaging effects could easily be exaggerated by other popular hepatotoxic drugs, such as 17aa oral steroids.



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Testosterone it’s What separates the men from the boys


Remember what it was like to be young and full of testosterone? The day you used to wake up with a massive rock hard morning wood and at that time in your life hardly even knew what to do with it. How about the good old days when you could down a package of Oreo’s with a gallon of milk without even gaining a single pound? What about that feeling of power and cockiness that was always present with you as a young man. Feeling like king of the world, no one could stand in your way and every woman on earth wanted to you because you were so perfect in every way. Oh yes those sure where the days that have long since passed, Or have they? Are these days gone forever or can we regain some of these feelings once again?

Testosterone is a lot more than just the pesky hormone that gets young boys into trouble. It’s responsible for much more than a teenage boys rebellion well going through the changes of life. Thankfully we have learned much more about testosterone. Immaturity is what gets a young man in trouble, but testosterone is what separates the men from the boys.


What is Testosterone?

Testosterone is a steroid hormone from the androgen group and is also the MAIN hormone in a male’s body. In mammals, testosterone is primarily secreted by the testes of males and by the ovaries of females, while a tiny amount is also secreted by the adrenal glands. It is the main male sex hormone and an anabolic steroid. Testosterone plays a key role in the development of male reproductive tissues which are the testis and prostate. Testosterone also promotes secondary sexual characteristics such as increased muscle and bone mass, hair growth, sexual behavior, development of the male genitals, increased glands, and sperm production. The adult human male body produces about ten times more testosterone than an adult human female body, but females are more sensitive to the testosterone. The brain and the bones are two important tissues in humans where the main effect of testosterone is carried out by way of aromatization to estradiol. Testosterone in the bones allows estradiol to accelerate maturation of the cartilage into bone, leading to closure of the epiphyses and end of growth. This in short explains why when young girls reach menarche, their growth starts to stunt. Estradiol serves as the most important feedback signal to the hypothalamus which triggers LH production. Testosterone is derived from cholesterol which is why people who suffer from cholesterol issues usually have low testosterone. Testosterone is a hormone that is triggered through the HPTA (hypothalamus). When the HPGA Axis is stimulated, the hypothalamus secretes gonadotropin-releasing hormone (GnRH), which on reaching the anterior pituitary, binds to the gonadotrophs and stimulates the release of both the luteinizing hormone (LH) and follicle stimulatinghormone (FSH) into the bloodstream. In the testes, testosterone is produced by the Leydig cells. The male generative glands additionally contain Sertoli cells which require testosterone for spermatogenesis. Like most hormones, testosterone is supplied to target tissues in the blood where much of it is transported bound to a specific plasma protein gondal, called the "sex hormone binding globulin" otherwise known as (SHBG). In males, LH binds to Leydig cells, stimulating production of the principal Leydig cell hormone, testosterone. Testosterone is secreted to the plasma and also carried to Sertoli cells by androgen binding protein (ABP). In Sertoli cells the 4 double bond of testosterone is reduced, producing dihydrotestosterone. A little more than 5% of testosterone is reduced to 5a-dihydrotestosterone (DHT) by the cytochrome through the enzyme 5a reductase. The conversion of testosterone to DHT leads to more sebaceous glands which in turn can leads to oily skin and acne. Less than 1% of testosterone is converted into estradiol by aromatase; also known as the CYP19A1 enzyme. Going back to the Sertoli Cells, in these cells it is regulated by FSH, again acting through a cAMP- and PKA-regulatory pathway. In addition, FSH stimulates Sertoli cells to secrete androgen-binding protein (ABP), which transports testosterone and DHT from Leydig cells to sites of spermatogenesis. There testosterone acts to stimulate protein synthesis and sperm development. Aromatase activity is also found in granulosa cells, but in these cells the activity is stimulated by FSH. Typically, then the cal-cell androgens produced in response to LH distribute to granulosa cells, whereas granulosa cell aromatase converts these androgens to estrogens. As granulosa cells mature they develop capable large numbers of LH receptors in the plasma membrane and become increasingly receptive to LH, increasing the amount of estrogen created from these cells. If not controlled it could lead to problems such as suppressed testosterone or gynecomastia due to the excess E2 levels. In a real short simplified expression; more SHBG leads to more Estrogen which leads to eventual negative effects.[2] Testosterone biosynthesis involves the cleavage of the sidechain of cholesterol by CYP11A, a mitochondrial cytochrome P450 oxidase with the loss of six carbon atoms to become pregnenolone ( the master precursor to all hormones). Next, two additional carbon atoms are removed by the CYP17A enzyme in the endoplasmic reticulum to give up a variety of carbon 19 steroide. In addition, the 3-hydroxyl group is oxidized by 3-ß-HSD to produce androstenedione. In the final and rate limiting step, the C-17 keto group androstenedione is condensed by 17-ß hydroxysteroid dehydrogenase to give way to testosterone.

From reading this explanation of how testosterone is produced even the untrained eye can see a few easy ways one can increase their testosterone production. By increasing the master hormone pregnenolone, by increasing Lutinizing hormone, and or by lowering shbg are just some of the many ways one can begin to raise natural test levels and gain its benefits once again.

Testosterone’s effect on blood Glucose Levels

Androgen (specifically testosterone) deficiency has in recent times come to the forefront of the medical literature after being overlooked for decades. The popularity of hypogonadism is greater than previously thought. Important links are being developed and established in the literature between androgen deficiency and metabolic disorders. There is an important health impact related to metabolic syndrome, insulin resistance, type 2 diabetes, and eventually vascular disease and ERECTILE DYSFUNCTION! Low concentrations of testosterone are associated with insulin resistance and mixed up in hyperglycemia, hypertension, dyslipidemia, and an increased risk of vascular disease. The increasing number of individuals with obesity and low testosterone continue to show the same continuous pattern. I came across a study that consisted of over 6000 men, the men with higher serum levels of testosterone were at much lower risk of type 2 diabetes than men with lower levels of testosterone. [6] Low testosterone demonstrated to have adverse effects on insulin levels and sudden spurts in blood glucose levels. From research lower total testosterone levels leads to less insulin resistance which equates to more body fat distribution. Research indicates insulin is capable of stimulating testosterone production in vivo and at the same time reducing SHBG concentrations in both normal-weight and obese men. Since testosterone SIGNIFIGANTLY boosts insulin sensitivity it also gives leeway for glycemic control which allow one to EAT MORE CARBOHYDRATES without any problem whatsoever! This explains why you hear people saying “when I was a young dude I was able to pound two quarter pounders with NO problem, but now if I eat one quarter pounder I get extremely bloated, those were the good old days.”

Aside from raining testosterone levels there are also powerful products that can have a outstanding positive effect on healthy insulin sensitivity. one such product of this nature would be Need2slin Need2slin and also

Testosterone is the Fountain of Youth?

Here is a small excerpt from a study that shows how testosterone declines within age which affects many organs and functions of the body. “Concentrations of sex steroids (especially testosterone) in serum decline progressively with age in men, as a result of complex alterations in reproductive physiology secondary causes of gonadal dysfunction and lifestyle factors and changes in the levels of binding proteins. Treatment of hypogonadism in younger and older men may result in an improvement in some relevant measures (e.g. osteopenia, sexual dysfunction, and muscle weakness). The average age of the study sample was 73 years of age and 389 (15%) were age 80 or older. Approximately 75% were Caucasian. Most reported themselves to be in excellent or good health compared with their peers. There were few current smokers, but a large proportion had smoked in the past. Alcohol consumption was four drinks per week on average. With the exception of race, distributions of these characteristics were not significantly different from those in the entire MrOS cohort. As men age; their SHBG levels rise and their total/free testosterone drops along their estradiol levels causing a loss in bone density. Higher BMI was related to lower testosterone and SHBG levels and higher estradiol concentrations. Total and free testosterone levels were slightly higher in men who rated their health status as excellent/good compared with those who rated it as fair/poor/very poor and were slightly higher in current smokers. Total testosterone levels were lower in Asian men and higher in African-American and Hispanic men. Free testosterone levels differed significantly by race (unadjusted P < 0.001; age- and BMI-adjusted P < 0.001) following the same trends as for total testosterone. No significant differences in total estradiol by race category were found. Unadjusted free estradiol differed slightly by race (P < 0.03) with whites having the lowest free estradiol concentration; however, after adjusting for age and BMI, the differences by race category diminished. SHBG concentrations differed by race category with Asian men having the lowest SHBG concentration and African-American and white men having the highest mean concentrations. Increasing levels of BMI positively, but slightly, influenced free estradiol. A larger proportion of free estradiol levels were related to free testosterone (positively) and SHBG (negatively) levels. Men with the highest free testosterone and lowest SHBG levels had free estradiol levels approxi-mately 3-fold higher than those with the lowest free testosterone and highest SHBG concentrations. The relationships between free testosterone and free estradiol, and between SHBG and estradiol, were linear. The concentrations of SHBG were slightly higher with greater age, were positively related to total testosterone levels, and were negatively associated with free estradiol levels. The rate of decline in free testosterone in older men is about 10% per decade. Higher SHBG levels were related to lower estradiol levels independent of free testosterone, suggesting that either SHBG has effects on estradiol levels over and above its testosterone-binding properties or that SHBG is actually a surrogate for other variables that may affect both SHBG and estradiol levels.” [7]

Another study showed total testosterone of elderly men were inversely associated with weight, BMI, waist to hip ratio, systolic and diastolic blood pressure, fasting plasma glucose and/or serum insulin, HOMA-IR, triglycerides, CRP and leptin levels and positively related to HDL cholesterol and adiponectin levels. Total testosterone was slightly lower among men who consumed at least one alcohol drink daily, compared with those who drank less or not at all. Those who maintained a healthy BMI/LBM index maintained higher levels of total testosterone. The risk of death was significantly elevated for men in the lowest quartile of the total and bioavailable(free) testosterone distributions. Low total and bioavailable testosterone were each significantly associated with elevated 20-years decline period risk of Cardio Vascular Disease mortality and death due to respiratory disease but not from cancer or death due to other fatal causes. Renal, liver disease, stroke and pulmonary disease have also been linked to low total and free testosterone in older men. [8]

Now both these articles conclude that it would be REALLY BENEFICIAL to take TRT (testosterone replacement therapy) if suffering from hypogonadism; which is primarily found in older men. Men who suffer from low testosterone do not get to reap the fruits of life as much as those who have higher levels of testosterone. Lots of older men use Testosterone replacement therapy to increase Rapid Eye Movement (REM) sleep in order to recover efficiently. There are studies that show that older men use testosterone replacement treatment for a better sense well of being. There are countless studies that show the distinct relationship between depression and testosterone levels. Depression and anxiety lead to lower levels of total and free testosterone, which would explain why certain SSRI’s have a noticeable effect on testosterone levels, serotonin along other neurotransmitters have been linked to effecting hormonal output. The one issue that some older men have with TRT is the higher increments in hemoglobin and hematocrit than young men after adjusting for testosterone levels. When older men take solid doses of testosterone studies show that they lose fat real quickly along with added muscle mass. These traits can be attributed to the ANABOLIC EFFECTS OF TESTOSTERONE! When men are receiving injections of testosterone; automatically nitrogen retention and protein synthesis capabilities rise much higher than the norm. This allows the individual the ability to consume more protein making anabolism even easier. Of course as age heightens; libido drops and old men lose the will or desire to engage in sexual activity. Testosterone also improves HDL which helps cholesterol in return providing proper blood flow to the corpus cavernosum allowing MAXIMUM erection strength. Testosterone replacement therapy has been touted to prevent osteoporosis through increasing the bone mineral density, when testosterone has a good ratio with estrogen it provides a nice sturdy foundation for bone structure, which again re-establishes the importance of testosterone to the male body. Older men as well as young men both deserve to enjoy the benefits of testosterone whether it is through endogenous or exogenous means.


Sleep really does Testosterone some Good!

Sleep really does Testosterone some Good!

Recent research suggests that testosterone plays a role in regulating the CNS during sleep and vice versa. When sleeping in particularly during Rapid Eye Movement; testosterone levels raise dramatically, however as one awakes and encounters the typical stressors, testosterone levels gradually fall throughout the waking day. Rapid Eye Movement occurs in intervals of 90 minutes per stage of sleep, so if one were to sleep 8 hours, the individual could go through REM about 6 times throughout their sleep. Sleep deprivation results in a collection of widespread symptoms leading to alterations in catecholamine, hormone levels, and behaviors. In particular, sleep loss has been connected with altered regulation of the hypothalamic-pituitary adrenal axis, and it impairs gonadal function by producing a marked reduction in testosterone concentration. Subnormal testosterone concentrations may contribute to sexual inadequacy in humans, which may affect established or desired sexual relations. Sleep deprivation really negatively impacts over trained athletes, so those who compete as an athlete NEED to sleep in order for their body to maximize its hormonal production. When sleep is interrupted, the rise of testosterone is also interrupted causing a sudden drop, again REM is EXTREMLY important for the rise of testosterone during sleep. The endocrine system (specifically TESTOSTERONE) has a responsibility to maintain the metabolic processes needed for tissue repair, regeneration, and recovery. The circulating testosterone levels also are play a role in erection frequency, as time goes erection during REM lessens, which would also would explain the correlation of testosterone with libido. Sleep deprivation can lead to many sleep disorders, one common one is linked to testosterone, and this disorder is Sleep Apnea. Sleep Apneic males with severe breathing issues exhibited delayed peak testosterone concentrations. Men with severe obstructive sleep apnea show significantly reduced serum concentrations of free and total testosterone and of sex hormone-binding globulin (SHBG), though their LH levels are normal. This endocrine defect was reversed after 3 months of continuous positive airway pressure (CPAP) therapy. Males who take artificial amounts of testosterone also may have issues with sleep disturbances. Testosterone raises the nocturnal metabolic rate which can negatively affect the way one sleeps. Again realize these are people on cycle and not people with normal amounts of testosterone. Basically low or TOO high levels of testosterone can negate REM sleep which is why one should get blood work done to see where they stand. Many studies show that sleep deprivation leads higher cortisol levels and lower total/free testosterone levels, so I tell you all SLEEP AND SLEEP WELL! Higher testosterone leads to better sleep and more frequencies of REM. [4]

For anyone needing help getting to sleep and staying a sleep at night Need2sleep is the perfect sleep aid Need 2 Sleep . Not only will it help get you to sleep faster but it helps get you into a deep sleep and keeps you there longer.

Testosterone good for the Brain!


Unlike what people may have thought due to the common “MeatHead” nickname given to muscular dumb guys, testosterone increases neurological function. An article I came across showed that as a result of decline in age, testosterone dropped, this led to increased risks for Alzheimer’s disease. Men with Alzheimer’s disease had lower levels of serum testosterone; this explains how both testosterone and estrogen have neuro-stimulative properties. Since Testosterone and Estrogen are neurosteroids this means they would also help prevent one from easily acquiring Addison’s disease. I even saw some research on PubMed that displayed testosterone’s importance in preventing Dementia, another “Slowing down of the Brain” disease. This is why dopamine in abundance has a positive effect on testosterone, although too much dopamine can cause over-stimulation leading to Schizophrenia. Some of you may be saying what he means by “neuro-stimulation”. When one ingests 200mg of caffeine, they are ingesting a bunch of stimulants which cause your neurotransmitters to rapidly fire, well certain sex hormones like testosterone act in this matter without the jittery feeling. This effect allows for better awareness, mental clarity, mental acuity, increased memory and so on. Caffeine has been proven to be effective in improving cognitive function, this goes to show you that when you compare caffeine to testosterone in the way they effect the brain, they both positive since they delay the effects of Dementia while allowing you to do more mental tasks


So far we have seen that testosterone is good for the heart, respiratory system, brain function, blood glucose levels, cholesterol, bone density, sense of well being, and now we see testosterone’s anabolic properties. Here is a full abstract from another article that shows the anabolic benefits of testosterone:


“Testosterone Therapy Prevents Gain in Visceral Adipose Tissue and Loss of Skeletal Muscle in Nonobese Aging Men

C. A. Allan, B. J. G. Strauss, H. G. Burger, E. A. Forbes and R. I. McLachlan

Prince Henry’s Institute (C.A.A., H.G.B., E.A.F., R.I.M.), Andrology Australia (C.A.A., R.I.M.), and Departments of Obstetrics and Gynecology (C.A.A., R.I.M.) and Medicine (B.J.G.S.), Monash University; and Clinical Nutrition and Metabolism Unit (B.J.G.S.), Monash Medical Centre, Monash University, Clayton, Victoria 3168, Australia

Address all correspondence and requests for reprints to: Professor R. I. McLachlan, Prince Henry’s Institute, P.O. Box 5152, Clayton, Victoria 3168, Australia. E-mail:[email protected] .

Background: Trials of testosterone therapy in aging men have demonstrated increases in fat-free mass (FFM) and skeletal muscle and decreases in fat mass (FM) but have not reported the impact of baseline body composition.

Objective: The objective of the study was to determine the effect, in nonobese aging men with symptoms of androgen deficiency and low-normal serum testosterone levels, of testosterone therapy on total and regional body composition and hormonal and metabolic indices.

Methods: Sixty healthy but symptomatic, nonobese men aged 55 yr or older with total testosterone (TT) levels less than 15 nM were randomized to transdermal testosterone patches or placebo for 52 wk. Body composition, by dual-energy x-ray absorptiometry (FM, FFM, skeletal muscle) and magnetic resonance imaging (abdominal sc and visceral adipose tissue, thigh skeletal muscle, and intermuscular fat) and hormonal and metabolic parameters were measured at wk 0 and 52.

Results: Serum TT increased by 30% (P = 0.01), and LH decreased by 50% (P < 0.001). Relative to placebo, total body FFM (P = 0.03) and skeletal muscle (P = 0.008) were increased and thigh skeletal muscle loss was prevented (P = 0.045) with testosterone therapy and visceral fat accumulation decreased (P = 0.001) without change in total body or abdominal sc FM; change in visceral fat was correlated with change in TT levels (r2 = 0.36; P = 0.014). There was a trend to increasing total and low-density lipoprotein cholesterol with placebo.

Conclusion: Testosterone therapy, relative to placebo, selectively lessened visceral fat accumulation without change in total body FM and increased total body FFM and total body and thigh skeletal muscle mass”.



PCT

now you guys can see that PCT (Post Cycle Therapy) is crucial to maintain gains and boost overall health. Many studies and blood panels have shown that PCT boosts liver cells, better ALT/LST levels, good cholesterol, proper testosterone to estrogen ratios, proper testosterone to cortisol ratios, solid IGF levels, proper hypothalamus function, proper brain function, good adrenals, good sense of well being, anti-oxidative, anti-cancerous, restoration of distorted blood vessels, proper maintenance of SHBG’s, bone and ligament/joint protection. As you can see there is plenty of reasons to have a PCT aligned besides maintaining gains. I have always been a firm believer of keeping testosterone and FREE testosterone levels up in order to keep vitality and overall quality of life. There are many way PCT protocols once could follow, I suggest do your own research and see what fits you best. Before/after a cycle and post PCT one should follow their body by doing hormonal/organ blood work to see where you stand.



Supplements to boost testosterone naturally!

For years people have tried many ways to boost testosterone naturally for their specific means of interest. We had the tribulus error which was proven not to do much for the human male. Studies recently suggest that tribulus does boost androgen receptors within the brain which causes the rise in libido associated with supplementation of it. Now AI’s have been proven to raise LH output, increase both total and FREE testosterone while lowering estrogen. Formestane, 6bromo, Exemestane, arimadex all do the job in boosting total/free testosterone while blocking estrogen. 6-bromo and Formestane also block prolactin which allows for even MORE TOTA/FREE TESTOSTERONE boost. It is able to block prolactin by blocking the progesterone receptors at the same time it blocks the estrogen receptors. This would make Formestane an IDEAL otc AI while on Deca to avoid the unwanted “deca-dick”. The benefits of Formestane are really undeniable and should be a part of everyone’s artillery. Formestane also boosts IGF levels which mean MORE MUSCLE GROWTH. Formestane can be used as a standalone, on cycle and during PCT! I did not mention ATD why, simple it has anti-androgen properties since it blocks the androgen receptor in the brain which leads to a lack of libido. It also does not boost testosterone levels as once thought, it appears that ATD provides false testosterone levels because ATD contains metabolites similar to Testosterone which cause the false high positives. Currently there are three reliable sources of Formestane:
1. Competitive Edge Labs Formestane
2. Formestane LV
3. https://www.mrsupps.com/Product-Forma-Stanzol_26.aspx

In this article: BCAAs raise T levels in bodybuilders

We get to see how effective BCAA’s are in boosting testosterone since they reduce cortisol levels which rise during intense training. People have tried to deny the effectiveness of BCAA’s but as you can see it boosts testosterone. It only took 6 grams of BCAA’s for 4 weeks to see a noticeable difference. Now imagine taking the effects of Gear (Bovine super plasma blood serum) which is 3x more potent than standard BCAA’s, this means MORE TESTOSTERONE boost and MORE MUSCLE PRESERVATION! More testosterone leads to gains in MUSCLE MASS, STRENGTH, RECOVERY, and a BETTER YOU!

HCGenerate brings a revolution to all herbal testosterone boosters because it contains a specific extract of Fadogia. Fadogia has shown to increase total testosterone levels at 6x more than that of some of the other popular herbal raws. It helps preserve and create new leydig cells which allows for more conversion of cholesterol to testosterone. Its ability to boost LH and testosterone dramatically makes it very comparable to HCG, which is why HCGenerate can be used on cycle to minimize shutdown; allowing PCT to be a breeze. HCGenerate also contains testofen which has been shown to DOUBLE FREE testosterone levels in HUMAN males. Free testosterone means that one is able to achieve the anabolic and androgenic effects of testosterone. When testosterone is not free; its USELESS because it cannot be used for any masculine purpose. So if one has really high testosterone but low free testosterone; they will not really reap the benefits that someone on a cycle of testosterone will receive. HCGenrate also contains Divanil which boosts FREE testosterone, lowers SHBG levels and boosts Nitric Oxide levels. HCGenerate is a MUST if you plan on using a SERM( Selective Estrogen Receptor Modulator) because SERM’s have been proven to raise SHBG’s which will drop free (useable) testosterone. Eventually high SHBG’s leads to not only low Free testosterone but Low total testosterone as seen with older individuals.

7,8 Benzoflavone has always intrigued me because of its effectiveness. There are studies that show boosts testosterone by increasing GrRH release in which it stimulates GABAergic modulation and at the same time blocks estrogen due to its AI properties. It has an IC50 value of 70nm which is RIDICULOUS for an herbal raw, this explains why individuals who use this raw have dramatic boosts in testosterone with low LH levels. This raw converts LH to testosterone at a high rate while keep estrogen to a norm; giving it a nice 1-2 punch. I have seen my testosterone levels with bloodwork boost over 50% which is definitely impressive and lets me know it’s a must to add in my PCT with HCGenerate. Forma-stanzol again has what you need and contains 7,8 benzoflavone.

https://www.mrsupps.com/Product-Forma-Stanzol_26.aspx

Forged Steel has really caught my eye as of recently since it boosts libido DRAMATICALLY and boosts testosterone at the same time! Let’s start off with the pumpkin seed powder that Forged Steel contains. Pumpkin seed powder has an abundance of Zinc which is crucial for maintaining testosterone efficiency, along bone density strength. Zinc protects the prostate from prostate enlargement which can be fatal. Zinc also is important for fertility in providing more counts of semen and semen mobility. Solid levels of Zinc also prevent testosterone from converting to DHT at a high rate which is what you want. Pumpkin Powder Seed has also been touted to raise FEMALE’S LIBIDO through her olfactory system. In essence, the scent of pumpkin makes a woman wetter in her “special place” which is what any testosterone filled dude wants! Companies are now starting to make colognes with Pumpkin seed powder extract to entice men to purchase their product. So it’s real simple, ingesting pumpkin seed leads to a concentration of pumpkin seed in the body, which leads to pore concentration, finally translates to women appeal and a good chance of GETTING LAID! Forged Steel also contains Muira Puama which decreases prolactin leading to increased TOTAL testosterone levels. It also boosts dopamine levels which lead to HARDER ERECTIONS and LASTING LONGER in the bedroom! Forged Steel is the REAL DEAL if you are looking for a quick boost prior to sexual activity.
FORGED STEEL - OrbitNutrition

One more raw I want you all to witness is mytosterone, this bad boy has been proven to boost testosterone by 60% while blocking estrogen by 9% and blocking DHT conversion by 20 plus %. Here is an excerpt to the study that showcases mytosterone:

“BACKGROUND: Maintaining endogenous testosterone (T) levels as men age may slow the symptoms of sarcopenia, andropause and decline in physical performance. Drugs inhibiting the enzyme 5alpha-reductase (5AR) produce increased blood levels of T and decreased levels of dihydrotestosterone (DHT). However, symptoms of gynecomastia have been reported due to the aromatase (AER) enzyme converting excess T to estradiol (ES). The carotenoid astaxanthin (AX) from Haematococcus pluvialis, Saw Palmetto berry lipid extract (SPLE) from Serenoa repens and the precise combination of these dietary supplements, Alphastat(R) (Mytosterone(trade mark)), have been reported to have inhibitory effects on both 5AR and AER in-vitro. Concomitant regulation of both enzymes in-vivo would cause DHT and ES blood levels to decrease and T levels to increase. The purpose of this clinical study was to determine if patented Alphastat(R) (Mytosterone(trade mark)) could produce these effects in a dose dependent manner. METHODS: To investigate this clinically, 42 healthy males ages 37 to 70 years were divided into two groups of twenty-one and dosed with either 800 mg/day or 2000 mg/day of Alphastat(R) (Mytosterone(trade mark)) for fourteen days. Blood samples were collected on days 0, 3, 7 and 14 and assayed for T, DHT and ES. Body weight and blood pressure data were collected prior to blood collection. One-way, repeated measures analysis of variance (ANOVA-RM) was performed at a significance level of alpha = 0.05 to determine differences from baseline within each group. Two-way analysis of variance (ANOVA-2) was performed after baseline subtraction, at a significance level of alpha = 0.05 to determine differences between dose groups. Results are expressed as means +/- SEM. RESULTS: ANOVA-RM showed significant within group increases in serum total T and significant decreases in serum DHT from baseline in both dose groups at a significance level of alpha = 0.05. Significant decreases in serum ES are reported for the 2000 mg/day dose group and not the 800 mg/day dose group. Significant within group effects were confirmed using ANOVA-2 analyses after baseline subtraction. ANOVA-2 analyses also showed no significant difference between dose groups with regard to the increase of T or the decrease of DHT. It did show a significant dose dependant decrease in serum ES levels. CONCLUSION: Both dose groups showed significant (p = 0.05) increases in T and decreases in DHT within three days of treatment with Alphastat(R) (Mytosterone(trade mark)). Between group statistical analysis showed no significant (p = 0.05) difference, indicating the effect was not dose dependent and that 800 mg/per day is equally effective as 2000 mg/day for increasing T and lowering DHT. Blood levels of ES however, decreased significantly (p = 0.05) in the 2000 mg/day dose group but not in the 800 mg/day dose group indicating a dose dependant decrease in E levels.”
Myodrol 120 caps, Axis Labs - OrbitNutrition

Pretty impressive huh, I think a stack of Myodrol, HCGenerate and forma-stanzol would be INSANE providing that one will SIGNIFIGANTLY boost total/free testosterone, lower conversion of testosterone to DHT and estradiol, and preventing high aromatization. The only supplement that has a legit dose of mytosterone is myodrol by Axis Labs: Myodrol 120 caps, Axis Labs - OrbitNutrition



Be it just to feel naturally more like a man or to help feel less like a woman during pct, Testosterone is what separates the men from the boys my friends and now you know how to get you some.




Sources:
1.Journal of Clinical Endocrinology & Metabolism Vol. 37, No. 1 148-151
doi:10.1210/jcem-37-1-148

2. Michael R. Waterman, Genes Involved in Androgen Biosynthesis and the Male PhenotypeDiane S. KeeneyDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tenn., USA Vol. 38, No. 5-6, 1992

3.Steroid Hormones

4. Monica Levy Andersen*, Sergio Tufik. The effects of testosteroneonsleep and sleepdisorderedbreathing in men:Its bidirectionalinteraction with erectile function. Sleep Medicine Reviews (2008) 12, 365e379 (http://www.sono.org.br/pdf/2008_Ande...ep_Med_Rev.pdf)

5. ABDULAMAGED M. TRAISH, ANDRE GUAY, FARID SAAD. The Dark Side of Testosterone Deficiency: II. Type 2 Diabetes and Insulin Resistance. Journal of Andrology, Vol. 30, No. 1, January/February 2009. (The Dark Side of Testosterone Deficiency: II. Type 2 Diabetes and Insulin Resistance -- Traish et al. 30 (1): 23 -- Journal of Andrology)

6. Ding EL, Song Y, Malik VS, Liu S. Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis. JAMA. 2006;295: 1288 –1299.[

7. Testosterone and Estradiol among Older Men. The Journal of Clinical Endocrinology & Metabolism Vol. 91, No. 4 1336-1344

Testosterone and Estradiol among Older Men -- Orwoll et al. 91 (4): 1336 -- Journal of Clinical Endocrinology & Metabolism

8. Low Serum Testosterone and Mortality in Older Men. The Journal of Clinical Endocrinology & Metabolism Vol. 93, No. 1 68-75(2008)

Low Serum Testosterone and Mortality in Older Men -- Laughlin et al. 93 (1): 68 -- Journal of Clinical Endocrinology & Metabolism

9. Older Men Are as Responsive as Young Men to the Anabolic Effects of Graded Doses of Testosterone on the Skeletal Muscle. The Journal of Clinical Endocrinology & Metabolism Vol. 90, No. 2 678-688 (2005)

10. Jones, T.H. (Barnsley/Sheffield) (eds): Advances in the Management of Testosterone Deficiency. Testosterone, Bone and Osteoporosis Front Horm Res. Basel, Karger, 2009, vol 37, pp 123-132 (2010)

11. NEJM -- The Effects of Supraphysiologic Doses of Testosterone on Muscle Size and Strength in Normal Men

12.Age-Related Testosterone Depletion and the Development of Alzheimer Disease. Vol.292 Nov.12, Sept. 22-29, 2004

13. Behav Brain Res. 2010 Jan 20; 206(2): 216-22.

14.Inhibition of human estrogen synthetase (aromatase) by flavones JT Kellis, Jr et al.Science, Sep 1984; 225: 1032 - 1034.

15. Pumpkin Seeds Shown to Boost Sex Drive

16. An open label, dose response study to determine the effect of a dietary supplement on dihydrotestosterone, testosterone and estradiol levels in healthy males. Journal of the International Society of Sports Nutrition 2008, 5:12 (2008)

17. orbitnutrition.com

18. mrsupps.com

 

[chesty]

First, I read through this the very long posts, twice each. Engineer, that's what I do, I read a lot. Anyway, did a quick search and this is what I found from the national cancer institute. Tamoxifen: Questions and Answers - National Cancer Institute

you know the people who stand to make all this money from there studies


Tamoxifen (brand name Nolvadex) is now the most widely prescribed cancer medication in the world. It generated revenues of US $265 million in 1992. By 1995, worldwide sales of Nolvadex reached $400 million. (7) And at AUD $90 for one month's supply, it doesn't come cheap (the Australian Pharmaceutical Benefits Scheme covers $70).
Global sales of Tamoxifen in 2001 were $1,024 million.[54] Since the expiration of the patent in 2002, it is now widely available as a generic drug around the world. Barr Labs Inc had challenged the patent (which in 1992 was ruled unenforcable) but later came to an agreement with Zeneca to licence the patent and sell Tamoxifen at close to Zeneca's price.[55] As of 2004, Tamoxifen was the world's largest selling hormonal drug on record and off record may be the number 1 selling drug in word of all time to date. So we are truly talking about billions in revenue world wide for drug companies,sources,ug's and more. Money is at the root of this drug and why its so heavily pushed on all forums by everyone. Its cheap to make and it brings in billions plain and simple.


Tamoxifen: Questions and Answers

Key Points

* Tamoxifen (Nolvadex®) is a drug that interferes with the activity of estrogen, a female hormone. Tamoxifen has been used for more than 30 years to treat breast cancer in women and men (see Question 1).
* Tamoxifen has been used for almost 10 years to reduce the risk of breast cancer in women who are at increased risk of developing breast cancer (see Question 1).
* The known, serious side effects of tamoxifen are blood clots, strokes, uterine cancer, and cataracts. Other side effects include menopause-like symptoms such as hot flashes, vaginal dryness, joint pain, and leg cramps (see Questions 4-8).
* The benefits of tamoxifen as a treatment for breast cancer are firmly established and far outweigh the potential risks (see Question 11).
* The results of the Breast Cancer Prevention Trial (BCPT) showed a reduction in diagnoses of invasive breast cancer among women who took tamoxifen for 5 years (see Question 12).
* The results of the Study of Tamoxifen and Raloxifene (STAR) clinical trial showed that tamoxifen and another drug, raloxifene, are equally effective in reducing invasive breast cancer risk in postmenopausal women who are at increased risk of the disease (see Question 14).

1. What is tamoxifen?

Tamoxifen (Nolvadex®) is a drug, taken orally as a tablet, which interferes with the activity of estrogen, a female hormone. Estrogen can promote the development of cancer in the breast. Tamoxifen is approved by the U.S. Food and Drug Administration (FDA) for the prevention of breast cancer and for the treatment of breast cancer, as well as other types of cancer.

Tamoxifen has been used for more than 30 years to treat breast cancer in women and men. Tamoxifen is used to treat patients with early-stage breast cancer, as well as those with metastatic breast cancer (cancer that has spread to other parts of the body). As adjuvant therapy (treatment given after the primary treatment to increase the chances of a cure), tamoxifen helps prevent the original breast cancer from returning and also helps prevent the development of new cancers in the other breast. As treatment for metastatic breast cancer, the drug slows or stops the growth of cancer cells that are present in the body.

Tamoxifen has been used for almost 10 years to reduce the risk of breast cancer in women who are at increased risk of developing breast cancer. Tamoxifen is also used to treat women with ductal carcinoma in situ (DCIS), a noninvasive condition that sometimes leads to invasive breast cancer.
2. How does tamoxifen work?

Estrogen can promote the growth of breast cancer cells. Some breast cancers are classified as estrogen receptor-positive (also known as hormone sensitive), which means that they have a protein to which estrogen will bind. These breast cancer cells need estrogen to grow. Tamoxifen works against the effects of estrogen on these cells. It is often called an antiestrogen or a SERM (Selective Estrogen Receptor Modulator).

Studies have shown that tamoxifen is only effective in treating estrogen receptor-positive breast cancers. Therefore, the tumor’s hormone receptor status should be determined before deciding on treatment options for breast cancer.

Although tamoxifen acts against the effects of estrogen in breast tissue, it acts like estrogen in other tissue. This means that women who take tamoxifen may derive many of the beneficial effects of menopausal estrogen replacement therapy, such as a decreased risk of osteoporosis.
3. How long should a patient take tamoxifen for the treatment of breast cancer?

Patients with metastatic breast cancer may take tamoxifen for varying lengths of time, depending on the cancer’s response to this treatment and other factors. When used as adjuvant therapy for early-stage breast cancer, tamoxifen is generally prescribed for 5 years. However, the ideal length of treatment with tamoxifen is not known.

Two studies have confirmed the benefit of taking adjuvant tamoxifen daily for 5 years. When taken for 5 years, tamoxifen reduces the chance of the original breast cancer coming back in the same breast or elsewhere. It also reduces the risk of developing a second primary cancer in the other breast.

Clinical trials are ongoing to determine whether hormone therapy taken for more than 5 years is beneficial. These studies usually include aromatase inhibitors (AIs) (another type of antiestrogen) (see Question 15). For example, the National Cancer Institute (NCI), a part of the National Institutes of Health, is sponsoring the National Surgical Adjuvant Breast and Bowel Project (NSABP) B–42 trial. This trial is studying the AI letrozole (Femara®) to find out how well it works compared with a placebo in treating postmenopausal women who have received hormone therapy for hormone receptor-positive breast cancer. More information is available in PDQ®, the NCI’s comprehensive cancer information database, at Clinical Trials (PDQ®) - National Cancer Institute on the Internet.

The MA–17R trial, which is being coordinated by the National Cancer Institute of Canada’s Clinical Trials Group, is comparing letrozole with placebo in women previously diagnosed with primary breast cancer who participated in another clinical trial of letrozole. Information about the MA–17R trial can be found at https://www.swogstat.org/ROS/ROSBooks/Fall 2006/Intergroup/NCIC CTG/JMA17R.pdf on the Internet.
4. What are some of the more common side effects of tamoxifen?

The known, serious side effects of tamoxifen are blood clots, strokes, uterine cancer, and cataracts (see Questions 5–8). Other side effects of tamoxifen are similar to the symptoms of menopause. The most common side effects are hot flashes and vaginal discharge. Some women experience irregular menstrual periods, headaches, fatigue, nausea and/or vomiting, vaginal dryness or itching, irritation of the skin around the vagina, and skin rash. As with menopause, not all women who take tamoxifen have these symptoms. Men who take tamoxifen may experience headaches, nausea and/or vomiting, skin rash, impotence, or a decrease in sexual interest.
5. Does tamoxifen cause blood clots or stroke?

Data from large clinical trials suggest that there is a small increase in the number of blood clots in women taking tamoxifen, particularly in women who are receiving anticancer drugs (chemotherapy) along with tamoxifen. The total number of women who have experienced this side effect is small. The risk of having a blood clot due to tamoxifen is similar to the risk of a blood clot when taking estrogen replacement therapy.

The Breast Cancer Prevention Trial (BCPT), a large research study funded by the NCI, was designed to test the usefulness of tamoxifen in preventing breast cancer in women with an increased risk of developing this disease (see Question 12). This study also found that women who took tamoxifen had an increased chance of developing blood clots and an increased chance of stroke (1, 2).
6. Does tamoxifen cause cancers of the uterus?

Tamoxifen increases the risk of two types of cancer that can develop in the uterus: endometrial cancer, which arises in the lining of the uterus, and uterine sarcoma, which arises in the muscular wall of the uterus. Like all cancers, endometrial cancer and uterine sarcoma are potentially life-threatening. Women who have had a hysterectomy (surgery to remove the uterus) and are taking tamoxifen are not at increased risk for these cancers.

Endometrial Cancer
Studies have found the risk of developing endometrial cancer to be about 2 cases per 1,000 women taking tamoxifen each year compared with 1 case per 1,000 women taking placebo (1, 2). Most of the endometrial cancers that have occurred in women taking tamoxifen have been found in the early stages, and treatment has usually been effective. However, for some breast cancer patients who developed endometrial cancer while taking tamoxifen, the disease was life-threatening.

Uterine Sarcoma
Studies have found the risk of developing uterine sarcoma to be slightly higher in women taking tamoxifen compared with women taking placebo. However, it was less than 1 case per 1,000 women per year in both groups (1, 2). Research to date indicates that uterine sarcoma is more likely to be diagnosed at later stages than endometrial cancer, and may therefore be harder to control and more
life-threatening than endometrial cancer.

Abnormal vaginal bleeding and lower abdominal (pelvic) pain are symptoms of cancers of the uterus. Women who are taking tamoxifen should talk with their doctor about having regular pelvic examinations and should be checked promptly if they have any abnormal vaginal bleeding or pelvic pain between scheduled exams.
7. Does tamoxifen cause other types of cancer?

Tamoxifen is not known to cause any types of cancer in humans other than endometrial cancer and uterine sarcoma.
8. Does tamoxifen cause eye problems?

As women age, they are more likely to develop cataracts (clouding of the lens inside the eye). Women taking tamoxifen appear to be at increased risk for developing cataracts. Other eye problems, such as corneal scarring or retinal changes, have been reported in a few patients.
9. Should women taking tamoxifen avoid pregnancy?

Yes. Doctors advise women receiving tamoxifen to avoid pregnancy because animal studies have suggested that the use of tamoxifen during pregnancy can cause harm to the fetus. Women who have questions about fertility, birth control, or pregnancy should discuss their concerns with their doctor.
10. Does tamoxifen cause a woman to begin menopause?

Tamoxifen does not cause a woman to begin menopause, although it can cause some symptoms that are similar to those that may occur during menopause. In most premenopausal women taking tamoxifen, the ovaries continue to act normally and produce estrogen in the same or slightly increased amounts.
11. Do the benefits of tamoxifen in treating breast cancer outweigh its risks?

The benefits of tamoxifen as a treatment for breast cancer are firmly established and far outweigh the potential risks. Patients who are concerned about the risks and benefits of tamoxifen or any other medications are encouraged to discuss these concerns with their doctor.
12. Can tamoxifen prevent breast cancer?

Research has shown that when tamoxifen is used as adjuvant therapy for early-stage breast cancer, it reduces the chance that the original breast cancer will come back in the same breast or elsewhere. It also reduces the risk of developing new cancers in the other breast. Based on these findings, the NCI funded the BCPT to determine whether taking tamoxifen for at least 5 years can prevent breast cancer in women who have never been diagnosed with breast cancer but who are at increased risk of developing the disease. This study found a reduction in diagnoses of invasive breast cancer among women who took tamoxifen for 5 years. Women who took tamoxifen also had fewer diagnoses of noninvasive breast tumors, such as DCIS or lobular carcinoma in situ (LCIS) (1). After 7 years of follow-up, researchers found similar results (2). The study found that tamoxifen reduced the occurrence of estrogen receptor-positive tumors by 69 percent, but no difference in the occurrence of estrogen receptor-negative tumors was seen (1). More information about the BCPT is available on the NCI’s BCPT home page at The Breast Cancer Prevention Trial - National Cancer Institute on the Internet.
13. Who should take tamoxifen to reduce breast cancer risk?

The decision to take tamoxifen is an individual one. A woman and her doctor must carefully consider the benefits and risks of therapy. At this time, there is no evidence that tamoxifen has a net benefit for women who do not have an increased risk of developing breast cancer.
14. What is raloxifene and how does it compare to tamoxifen?

Raloxifene is a drug approved by the FDA for the prevention and treatment of osteoporosis in postmenopausal women. Raloxifene is also approved by the FDA for reducing the risk of invasive breast cancer in postmenopausal women with osteoporosis and in postmenopausal women at high risk for invasive breast cancer.

The NCI funded the Study of Tamoxifen and Raloxifene (STAR), a clinical trial comparing raloxifene (Evista®) with tamoxifen in preventing breast cancer in postmenopausal women who are at an increased risk of developing the disease. The study found that raloxifene and tamoxifen are equally effective in reducing invasive breast cancer risk in postmenopausal women who are at increased risk of the disease. The study also found that women who took raloxifene had fewer uterine cancers and fewer blood clots than the women who took tamoxifen (3). However, raloxifene did not reduce the risk of noninvasive breast tumors such as DCIS and LCIS (3). Other side effects associated with raloxifene were similar to tamoxifen and included hot flashes, vaginal dryness, joint pain, and leg cramps. Studies of raloxifene to date have only examined its role in breast cancer prevention, not treatment.

More information about STAR is available on the NCI’s STAR home page at Study of Tamoxifen and Raloxifene (STAR) Trial - National Cancer Institute on the Internet.
15. What other hormone therapy may be used for early-stage breast cancer?

Aromatase inhibitors (AIs) are another adjuvant treatment option for some women with early-stage breast cancer. AIs block the action of a protein called aromatase, which helps the body produce estrogen. Most of the estrogen in a woman’s body is made in the ovaries, but other tissues can also produce this hormone. AIs are usually used in women who have reached menopause, when the ovaries are no longer producing estrogen.

Although AIs and tamoxifen both help to prevent the growth of estrogen-sensitive breast tumors, they work differently in the body. Tamoxifen blocks the tumor’s ability to use estrogen, and AIs reduce the amount of estrogen in the body. Anastrozole (Arimidex®), exemestane (Aromasin®), and letrozole (Femara®) are AIs that have been approved by the FDA.

The American Society of Clinical Oncology (ASCO) recommends that postmenopausal women with hormone-sensitive breast cancer consider one of two adjuvant treatment options (4):
* Begin treatment with tamoxifen for 2 to 3 years or 5 years, and then switch to an AI for another 2 to 3 years or 5 years.
* Forego tamoxifen entirely and begin adjuvant treatment with an AI for 5 years.

ASCO concluded that AIs are appropriate as initial treatment for women who should not take tamoxifen and that patients who cannot take AIs should receive tamoxifen.

Whether an individual patient should start therapy with an AI or begin therapy with tamoxifen and then change to an AI is a subject of medical judgment and clinical research. Patients should talk with their doctors about which drug would be best for them given their particular medical situation.

Question 3 includes information about ongoing clinical trials involving AIs to treat postmenopausal women with hormone receptor-positive breast cancer.

Selected References

1. Fisher B, Costantino JP, Wickerham DL, et al. Tamoxifen for prevention of breast cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. Journal of the National Cancer Institute 1998; 90(18):1371–1388.

2. Fisher B, Costantino JP, Wickerham DL, et al. Tamoxifen for the prevention of breast cancer: Current status of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. Journal of the National Cancer Institute 2005; 97(22):1652–1662.

3. Vogel VG, Costantino JP, Wickerham DL, et al. Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: The NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 Trial. Journal of the American Medical Association 2006; 295(23):2727–2741.

4. Winer EP, Hudis C, Burstein HJ, et al. American Society of Clinical Oncology technology assessment on the use of aromatase inhibitors as adjuvant therapy for postmenopausal women with hormone receptor-positive breast cancer: Status report 2004. Journal of Clinical Oncology 2005; 23(3):619–629.

# # #

Related NCI materials and Web pages:

* National Cancer Institute Fact Sheet 3.76, Menopausal Hormone Replacement Therapy Use and Cancer
(Menopausal Hormone Replacement Therapy Use and Cancer - National Cancer Institute)
* National Cancer Institute Fact Sheet 4.18, Breast Cancer Prevention Studies
(Breast Cancer Prevention Studies - National Cancer Institute)
* National Cancer Institute Fact Sheet, The Study of Tamoxifen and Raloxifene (STAR): Questions and Answers
(STAR: Questions and Answers - National Cancer Institute)
* Breast Cancer Home Page
(Breast Cancer Home Page - National Cancer Institute)
* Breast Cancer Prevention Trial Home Page
(The Breast Cancer Prevention Trial - National Cancer Institute)
* Study of Tamoxifen and Raloxifene (STAR) Trial Home Page
(Study of Tamoxifen and Raloxifene (STAR) Trial - National Cancer Institute)
* Understanding Cancer Series: Estrogen Receptors/SERMs
(Estrogen Receptors/SERMs - National Cancer Institute)

How can we help?

We offer comprehensive research-based information for patients and their families, health professionals, cancer researchers, advocates, and the public.

* Call NCI’s Cancer Information Service at 1–800–4–CANCER (1–800–422–6237)
* Visit us at National Cancer Institute - Comprehensive Cancer Information or Cncer en espaol - National Cancer Institute
* Chat using LiveHelp, NCI’s instant messaging service, at http://www.cancer.gov/livehelp
* E-mail us at [email protected]
* Order publications at http://www.cancer.gov/publications or by calling 1–800–4–CANCER
* Get help with quitting smoking at 1–877–44U–QUIT (1–877–448–7848)

see keep in mind when you read what these people have to say


Tamoxifen (brand name Nolvadex) is now the most widely prescribed cancer medication in the world. It generated revenues of US $265 million in 1992. By 1995, worldwide sales of Nolvadex reached $400 million. (7) And at AUD $90 for one month's supply, it doesn't come cheap (the Australian Pharmaceutical Benefits Scheme covers $70).
Global sales of Tamoxifen in 2001 were $1,024 million.[54] Since the expiration of the patent in 2002, it is now widely available as a generic drug around the world. Barr Labs Inc had challenged the patent (which in 1992 was ruled unenforcable) but later came to an agreement with Zeneca to licence the patent and sell Tamoxifen at close to Zeneca's price.[55] As of 2004, Tamoxifen was the world's largest selling hormonal drug on record and off record may be the number 1 selling drug in word of all time to date. So we are truly talking about billions in revenue world wide for drug companies,sources,ug's and more. Money is at the root of this drug and why its so heavily pushed on all forums by everyone. Its cheap to make and it brings in billions plain and simple.

 

[chesty]

First, I read through this the very long posts, twice each. Engineer, that's what I do, I read a lot. Anyway, did a quick search and this is what I found from the national cancer institute. Tamoxifen: Questions and Answers - National Cancer Institute



Tamoxifen: Questions and Answers

Key Points

* Tamoxifen (Nolvadex®) is a drug that interferes with the activity of estrogen, a female hormone. Tamoxifen has been used for more than 30 years to treat breast cancer in women and men (see Question 1).
* Tamoxifen has been used for almost 10 years to reduce the risk of breast cancer in women who are at increased risk of developing breast cancer (see Question 1).
* The known, serious side effects of tamoxifen are blood clots, strokes, uterine cancer, and cataracts. Other side effects include menopause-like symptoms such as hot flashes, vaginal dryness, joint pain, and leg cramps (see Questions 4-8).
* The benefits of tamoxifen as a treatment for breast cancer are firmly established and far outweigh the potential risks (see Question 11).
* The results of the Breast Cancer Prevention Trial (BCPT) showed a reduction in diagnoses of invasive breast cancer among women who took tamoxifen for 5 years (see Question 12).
* The results of the Study of Tamoxifen and Raloxifene (STAR) clinical trial showed that tamoxifen and another drug, raloxifene, are equally effective in reducing invasive breast cancer risk in postmenopausal women who are at increased risk of the disease (see Question 14).

1. What is tamoxifen?

Tamoxifen (Nolvadex®) is a drug, taken orally as a tablet, which interferes with the activity of estrogen, a female hormone. Estrogen can promote the development of cancer in the breast. Tamoxifen is approved by the U.S. Food and Drug Administration (FDA) for the prevention of breast cancer and for the treatment of breast cancer, as well as other types of cancer.

Tamoxifen has been used for more than 30 years to treat breast cancer in women and men. Tamoxifen is used to treat patients with early-stage breast cancer, as well as those with metastatic breast cancer (cancer that has spread to other parts of the body). As adjuvant therapy (treatment given after the primary treatment to increase the chances of a cure), tamoxifen helps prevent the original breast cancer from returning and also helps prevent the development of new cancers in the other breast. As treatment for metastatic breast cancer, the drug slows or stops the growth of cancer cells that are present in the body.

Tamoxifen has been used for almost 10 years to reduce the risk of breast cancer in women who are at increased risk of developing breast cancer. Tamoxifen is also used to treat women with ductal carcinoma in situ (DCIS), a noninvasive condition that sometimes leads to invasive breast cancer.
2. How does tamoxifen work?

Estrogen can promote the growth of breast cancer cells. Some breast cancers are classified as estrogen receptor-positive (also known as hormone sensitive), which means that they have a protein to which estrogen will bind. These breast cancer cells need estrogen to grow. Tamoxifen works against the effects of estrogen on these cells. It is often called an antiestrogen or a SERM (Selective Estrogen Receptor Modulator).

Studies have shown that tamoxifen is only effective in treating estrogen receptor-positive breast cancers. Therefore, the tumor’s hormone receptor status should be determined before deciding on treatment options for breast cancer.

Although tamoxifen acts against the effects of estrogen in breast tissue, it acts like estrogen in other tissue. This means that women who take tamoxifen may derive many of the beneficial effects of menopausal estrogen replacement therapy, such as a decreased risk of osteoporosis.
3. How long should a patient take tamoxifen for the treatment of breast cancer?

Patients with metastatic breast cancer may take tamoxifen for varying lengths of time, depending on the cancer’s response to this treatment and other factors. When used as adjuvant therapy for early-stage breast cancer, tamoxifen is generally prescribed for 5 years. However, the ideal length of treatment with tamoxifen is not known.

Two studies have confirmed the benefit of taking adjuvant tamoxifen daily for 5 years. When taken for 5 years, tamoxifen reduces the chance of the original breast cancer coming back in the same breast or elsewhere. It also reduces the risk of developing a second primary cancer in the other breast.

Clinical trials are ongoing to determine whether hormone therapy taken for more than 5 years is beneficial. These studies usually include aromatase inhibitors (AIs) (another type of antiestrogen) (see Question 15). For example, the National Cancer Institute (NCI), a part of the National Institutes of Health, is sponsoring the National Surgical Adjuvant Breast and Bowel Project (NSABP) B–42 trial. This trial is studying the AI letrozole (Femara®) to find out how well it works compared with a placebo in treating postmenopausal women who have received hormone therapy for hormone receptor-positive breast cancer. More information is available in PDQ®, the NCI’s comprehensive cancer information database, at Clinical Trials (PDQ®) - National Cancer Institute on the Internet.

The MA–17R trial, which is being coordinated by the National Cancer Institute of Canada’s Clinical Trials Group, is comparing letrozole with placebo in women previously diagnosed with primary breast cancer who participated in another clinical trial of letrozole. Information about the MA–17R trial can be found at https://www.swogstat.org/ROS/ROSBooks/Fall 2006/Intergroup/NCIC CTG/JMA17R.pdf on the Internet.
4. What are some of the more common side effects of tamoxifen?

The known, serious side effects of tamoxifen are blood clots, strokes, uterine cancer, and cataracts (see Questions 5–8). Other side effects of tamoxifen are similar to the symptoms of menopause. The most common side effects are hot flashes and vaginal discharge. Some women experience irregular menstrual periods, headaches, fatigue, nausea and/or vomiting, vaginal dryness or itching, irritation of the skin around the vagina, and skin rash. As with menopause, not all women who take tamoxifen have these symptoms. Men who take tamoxifen may experience headaches, nausea and/or vomiting, skin rash, impotence, or a decrease in sexual interest.
5. Does tamoxifen cause blood clots or stroke?

Data from large clinical trials suggest that there is a small increase in the number of blood clots in women taking tamoxifen, particularly in women who are receiving anticancer drugs (chemotherapy) along with tamoxifen. The total number of women who have experienced this side effect is small. The risk of having a blood clot due to tamoxifen is similar to the risk of a blood clot when taking estrogen replacement therapy.

The Breast Cancer Prevention Trial (BCPT), a large research study funded by the NCI, was designed to test the usefulness of tamoxifen in preventing breast cancer in women with an increased risk of developing this disease (see Question 12). This study also found that women who took tamoxifen had an increased chance of developing blood clots and an increased chance of stroke (1, 2).
6. Does tamoxifen cause cancers of the uterus?

Tamoxifen increases the risk of two types of cancer that can develop in the uterus: endometrial cancer, which arises in the lining of the uterus, and uterine sarcoma, which arises in the muscular wall of the uterus. Like all cancers, endometrial cancer and uterine sarcoma are potentially life-threatening. Women who have had a hysterectomy (surgery to remove the uterus) and are taking tamoxifen are not at increased risk for these cancers.

Endometrial Cancer
Studies have found the risk of developing endometrial cancer to be about 2 cases per 1,000 women taking tamoxifen each year compared with 1 case per 1,000 women taking placebo (1, 2). Most of the endometrial cancers that have occurred in women taking tamoxifen have been found in the early stages, and treatment has usually been effective. However, for some breast cancer patients who developed endometrial cancer while taking tamoxifen, the disease was life-threatening.

Uterine Sarcoma
Studies have found the risk of developing uterine sarcoma to be slightly higher in women taking tamoxifen compared with women taking placebo. However, it was less than 1 case per 1,000 women per year in both groups (1, 2). Research to date indicates that uterine sarcoma is more likely to be diagnosed at later stages than endometrial cancer, and may therefore be harder to control and more
life-threatening than endometrial cancer.

Abnormal vaginal bleeding and lower abdominal (pelvic) pain are symptoms of cancers of the uterus. Women who are taking tamoxifen should talk with their doctor about having regular pelvic examinations and should be checked promptly if they have any abnormal vaginal bleeding or pelvic pain between scheduled exams.
7. Does tamoxifen cause other types of cancer?

Tamoxifen is not known to cause any types of cancer in humans other than endometrial cancer and uterine sarcoma.
8. Does tamoxifen cause eye problems?

As women age, they are more likely to develop cataracts (clouding of the lens inside the eye). Women taking tamoxifen appear to be at increased risk for developing cataracts. Other eye problems, such as corneal scarring or retinal changes, have been reported in a few patients.
9. Should women taking tamoxifen avoid pregnancy?

Yes. Doctors advise women receiving tamoxifen to avoid pregnancy because animal studies have suggested that the use of tamoxifen during pregnancy can cause harm to the fetus. Women who have questions about fertility, birth control, or pregnancy should discuss their concerns with their doctor.
10. Does tamoxifen cause a woman to begin menopause?

Tamoxifen does not cause a woman to begin menopause, although it can cause some symptoms that are similar to those that may occur during menopause. In most premenopausal women taking tamoxifen, the ovaries continue to act normally and produce estrogen in the same or slightly increased amounts.
11. Do the benefits of tamoxifen in treating breast cancer outweigh its risks?

The benefits of tamoxifen as a treatment for breast cancer are firmly established and far outweigh the potential risks. Patients who are concerned about the risks and benefits of tamoxifen or any other medications are encouraged to discuss these concerns with their doctor.
12. Can tamoxifen prevent breast cancer?

Research has shown that when tamoxifen is used as adjuvant therapy for early-stage breast cancer, it reduces the chance that the original breast cancer will come back in the same breast or elsewhere. It also reduces the risk of developing new cancers in the other breast. Based on these findings, the NCI funded the BCPT to determine whether taking tamoxifen for at least 5 years can prevent breast cancer in women who have never been diagnosed with breast cancer but who are at increased risk of developing the disease. This study found a reduction in diagnoses of invasive breast cancer among women who took tamoxifen for 5 years. Women who took tamoxifen also had fewer diagnoses of noninvasive breast tumors, such as DCIS or lobular carcinoma in situ (LCIS) (1). After 7 years of follow-up, researchers found similar results (2). The study found that tamoxifen reduced the occurrence of estrogen receptor-positive tumors by 69 percent, but no difference in the occurrence of estrogen receptor-negative tumors was seen (1). More information about the BCPT is available on the NCI’s BCPT home page at The Breast Cancer Prevention Trial - National Cancer Institute on the Internet.
13. Who should take tamoxifen to reduce breast cancer risk?

The decision to take tamoxifen is an individual one. A woman and her doctor must carefully consider the benefits and risks of therapy. At this time, there is no evidence that tamoxifen has a net benefit for women who do not have an increased risk of developing breast cancer.
14. What is raloxifene and how does it compare to tamoxifen?

Raloxifene is a drug approved by the FDA for the prevention and treatment of osteoporosis in postmenopausal women. Raloxifene is also approved by the FDA for reducing the risk of invasive breast cancer in postmenopausal women with osteoporosis and in postmenopausal women at high risk for invasive breast cancer.

The NCI funded the Study of Tamoxifen and Raloxifene (STAR), a clinical trial comparing raloxifene (Evista®) with tamoxifen in preventing breast cancer in postmenopausal women who are at an increased risk of developing the disease. The study found that raloxifene and tamoxifen are equally effective in reducing invasive breast cancer risk in postmenopausal women who are at increased risk of the disease. The study also found that women who took raloxifene had fewer uterine cancers and fewer blood clots than the women who took tamoxifen (3). However, raloxifene did not reduce the risk of noninvasive breast tumors such as DCIS and LCIS (3). Other side effects associated with raloxifene were similar to tamoxifen and included hot flashes, vaginal dryness, joint pain, and leg cramps. Studies of raloxifene to date have only examined its role in breast cancer prevention, not treatment.

More information about STAR is available on the NCI’s STAR home page at Study of Tamoxifen and Raloxifene (STAR) Trial - National Cancer Institute on the Internet.
15. What other hormone therapy may be used for early-stage breast cancer?

Aromatase inhibitors (AIs) are another adjuvant treatment option for some women with early-stage breast cancer. AIs block the action of a protein called aromatase, which helps the body produce estrogen. Most of the estrogen in a woman’s body is made in the ovaries, but other tissues can also produce this hormone. AIs are usually used in women who have reached menopause, when the ovaries are no longer producing estrogen.

Although AIs and tamoxifen both help to prevent the growth of estrogen-sensitive breast tumors, they work differently in the body. Tamoxifen blocks the tumor’s ability to use estrogen, and AIs reduce the amount of estrogen in the body. Anastrozole (Arimidex®), exemestane (Aromasin®), and letrozole (Femara®) are AIs that have been approved by the FDA.

The American Society of Clinical Oncology (ASCO) recommends that postmenopausal women with hormone-sensitive breast cancer consider one of two adjuvant treatment options (4):
* Begin treatment with tamoxifen for 2 to 3 years or 5 years, and then switch to an AI for another 2 to 3 years or 5 years.
* Forego tamoxifen entirely and begin adjuvant treatment with an AI for 5 years.

ASCO concluded that AIs are appropriate as initial treatment for women who should not take tamoxifen and that patients who cannot take AIs should receive tamoxifen.

Whether an individual patient should start therapy with an AI or begin therapy with tamoxifen and then change to an AI is a subject of medical judgment and clinical research. Patients should talk with their doctors about which drug would be best for them given their particular medical situation.

Question 3 includes information about ongoing clinical trials involving AIs to treat postmenopausal women with hormone receptor-positive breast cancer.

Selected References

1. Fisher B, Costantino JP, Wickerham DL, et al. Tamoxifen for prevention of breast cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. Journal of the National Cancer Institute 1998; 90(18):1371–1388.

2. Fisher B, Costantino JP, Wickerham DL, et al. Tamoxifen for the prevention of breast cancer: Current status of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. Journal of the National Cancer Institute 2005; 97(22):1652–1662.

3. Vogel VG, Costantino JP, Wickerham DL, et al. Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: The NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 Trial. Journal of the American Medical Association 2006; 295(23):2727–2741.

4. Winer EP, Hudis C, Burstein HJ, et al. American Society of Clinical Oncology technology assessment on the use of aromatase inhibitors as adjuvant therapy for postmenopausal women with hormone receptor-positive breast cancer: Status report 2004. Journal of Clinical Oncology 2005; 23(3):619–629.

# # #

Related NCI materials and Web pages:

* National Cancer Institute Fact Sheet 3.76, Menopausal Hormone Replacement Therapy Use and Cancer
(Menopausal Hormone Replacement Therapy Use and Cancer - National Cancer Institute)
* National Cancer Institute Fact Sheet 4.18, Breast Cancer Prevention Studies
(Breast Cancer Prevention Studies - National Cancer Institute)
* National Cancer Institute Fact Sheet, The Study of Tamoxifen and Raloxifene (STAR): Questions and Answers
(STAR: Questions and Answers - National Cancer Institute)
* Breast Cancer Home Page
(Breast Cancer Home Page - National Cancer Institute)
* Breast Cancer Prevention Trial Home Page
(The Breast Cancer Prevention Trial - National Cancer Institute)
* Study of Tamoxifen and Raloxifene (STAR) Trial Home Page
(Study of Tamoxifen and Raloxifene (STAR) Trial - National Cancer Institute)
* Understanding Cancer Series: Estrogen Receptors/SERMs
(Estrogen Receptors/SERMs - National Cancer Institute)

How can we help?

We offer comprehensive research-based information for patients and their families, health professionals, cancer researchers, advocates, and the public.

* Call NCI’s Cancer Information Service at 1–800–4–CANCER (1–800–422–6237)
* Visit us at National Cancer Institute - Comprehensive Cancer Information or Cncer en espaol - National Cancer Institute
* Chat using LiveHelp, NCI’s instant messaging service, at http://www.cancer.gov/livehelp
* E-mail us at [email protected]
* Order publications at http://www.cancer.gov/publications or by calling 1–800–4–CANCER
* Get help with quitting smoking at 1–877–44U–QUIT (1–877–448–7848)

 

[chesty]

and this blurb on clomiphene.

Clomid (clomiphene) : Side effects, Long term effects, Misuse

Clomid - clomiphene for treating infertility

Clomid is one of the most commonly used drugs for treating infertile women, and most infertile women have taken this at some time during their treatment. You need to be aware of clomid side effects, because the side effects of clomid can reduce its efficacy. One of the commoner problems with clomid is the increased risk of having twins
( clomid twins have become very common !) and higher order multiple births. While the proper use of clomid can help many women to have a baby, and there are many clomid success stories, clomid can also cause hyperstimulation, so it's a drug which should be used with care. Interestingly, clomid can also be used as a diagnostic tool to test a woman's ovarian reserve, in what is called the clomid challenge test.

Clomid ( clomiphene citrate) is the drug of first choice for inducing ovulation – making women grow eggs. It is cheap, effective, easily available and well tolerated. It is also used for superovulating normal women to help them grow more eggs. Clomiphene is an antiestrogen and it acts by "fooling " the pituitary into believing that estrogen levels in the body are low as a result of which the pituitary starts producing more FSH and LH - the gonadotropin hormones which in turn leads to stimulation of the ovaries. Only women who produce estrogen will respond to clomiphene; and some doctors will test for this by seeing if they bleed in response to progestins - a progestin challenge test.

Instructions for using clomid are easy. The starting dose is one tablet (50 mg.) a day for five consecutive days. The first tablet can be taken on day 2, 3, 4 or 5 of the cycle . This is usually decided by the doctor and depends on the length of your menstrual cycle. It is not enough to just take clomiphene, it is equally important to monitor the response as well. This is best done by serial daily vaginal ultrasound scans or by using an ovulation prediction test kit ( OPK) such as Clearplan. The ovulation induced by clomiphene occurs about 5 to 7 days after the course of tablets is completed, that is, day 12-16 of the cycle. If ovulation fails to occur, the dose can be increased for subsequent cycles, till upto 200 mg per day. Often human chorionic gonadotrophin (HCG) is given to trigger ovulation to mimic the woman's natural LH surge. Ultrasound and blood oestrogen levels may be used to determine the best day to administer HCG. If ovulation does not occur, the patient becomes a candidate for treatment with gonadotropins ( HMG or FSH ).

Usually blood testing of progesterone levels (done 7 days after ovulation) accompanies clomiphene treatment to help identify the correct dosage needed. Clomiphene induces ovulation in approximately 70% of appropriately selected patients and has a 30% to 40% pregnancy rate. Most patients who conceive after clomid treatment do so in the first 4 months.

Clomiphene increases a woman's risk of twin pregnancy by approximately 10%. However, the risk of having more than two babies is 1%. Occasionally ovarian cysts occur following clomiphene administration. This is called hyperstimulation and it usually mild and self-limited. These usually disappear when the drug is stopped. The risk of clomid causing problems is more in women who have PCOD.

Side effects: can include hot flushes and mood swings early in the cycle and depression, nausea and breast tenderness later in the cycle. Severe headaches or visual problems, though rare, are indications to stop the medication.

Since clomiphene works as an "antioestrogen," it can have an adverse effect on cervical mucus, making it thicker than usual. It is therefore important to check on sperm/mucus survival with a postcoital or postinsemination test. If this is consistently negative due to poor mucus, a change of medication may be advised and some doctors prescribe tamoxifen or letrozole instead of clomiphene in this situation. Alternatively, low-dose estrogens may be added to your treatment.

Long term effects : As the drug is only given for 5 days early in the cycle it does not have any long, term effect on future ovulation or on hormone levels or on pregnancy. Some doctors were worried that the prolonged use of clomiphene would increase the risk of the patient developing ovarian cancer. However, extensive research has shown that this worry is unfounded.

Misuse of clomiphene: Clomiphene is an easy drug to misuse because it is cheap and easy to prescribe. It is common to find patients who have been taking clomiphene for months on end, with no result. Clomiphene should not be taken, unless adequate monitoring is also performed simultaneously. It should also not be prescribed for more than 6 months. If it hasn’t worked by then, you should move on to the next stage of treatment. Clomiphene is also commonly misused as "empiric " treatment - as a treatment to "enhance fertility" when the doctor cannot offer anything else.

Interestingly, clomid is also the most commonly prescribed medicine for infertile men - and the one which is most widely misused. Its use is largely empirical and very controversial as the results are not predictable. This is usually prescribed as a 25 mg tablet, to be taken once a day, for 25 days per month, for a course of 3 to 6 months. It acts by increasing the levels of FSH and LH, which stimulate the testes to produce testosterone and sperm. The group of men who seem to benefit the most from clomiphene have low sperm counts, with low or low-normal gonadotropin levels. However, while clomiphene may increase sperm counts in selected men, it hasn't been proven effective in increasing pregnancy rates.

 

[needtogetaas]

I think its sad that 9 out of 10 people ( even more so for steroid users) are blinded and brain washed by drug companies,fda,and the media... On the one side you all cry, Scream, and complain that the fda and the government keeps bashing you over the head with new drug laws and taking away rights. On the other hand the drug companies,fda, and government are working hard day and night to take away your rights to supplements and most could care less.

Has anyone ever stopped to think about why its so taking away supplements and passing new laws against them is so damn important to the fda and the government?

O they are just making sure people are safe right? Wrong! Over the last 80 years, organized medical groups and pharmaceutical companies, using lawyers, bribes, lobbyist, insurance companies and the strong arm of the Food and Drug Administration, have been very busy. They have corrupted elected officials to pass laws to remove any competition. They have crushed Natural Doctors, Natural Medicine, and Self-Care. Their goal is to monopolize health care and make us dependent on medical doctors and pharmaceutical drugs. It almost worked! We have watched them pass more and more laws restricting our rights; they have made many healing herbs, foods and even nutrients illegal. Natural health professionals that flourished a few decades ago are now barred by law to practice, and Natural Doctors, Holistic Healers, Health Food Store Owners and even family members of the sick have been arrested and jailed for using natural remedies. Big drug companies have been accused of putting profits above patients, spinning false PR campaigns and more.


Why do you think the FDA and the DRUG companies are moving against the supplement industry? Is it because supplements don't work?You know they want so badly for all of us to believe this and even people on this very forum are doing there part to help the FDA push this agenda.
So when you see some smuck trying to say supplements don't work you might want to stand up and tell the guy to shut his month and stop being so damn ignorant! Tell him to stop helping the FDA and big drug companies win the war they are wagging against your god given rights. Because that is exactly what they are doing.. I mean its getting so bad now these money hungry snakes have gone after Cheerios! I mean come one please Cheerios really?

Cheerios' Health Claims Break Rules, FDA Says - WSJ.com

See this is the plan of the drug companies and the FDA. First make it e-legal to make a claim that anything Natural can cure a disease. Then using the board of medicine clinically diagnose everything as a disease. Like aahh here is a good one "The Restless Legs Syndrome" http://www.rls.org/
I wish I was kidding but as you can see I am not. Everything from heart burn to acne is now becoming a medical condition that by law " Only a drug can cure" . Acne,Allergies,Anxiety,Arthritis,Asthma,Athlete's Foot, even bad breath they are making a medical condition that by law only a drug can claim it cures.

This leaves a question that some people keep asking. If supplements and natural compounds worked then drug companies and medical pharmaceutical companies would use them right? They would make and sell products using them if they worked right? Wrong again!

If they told the public the truth they would stand to lose trillions of dollars. Because you can not patten a natural herb. If it naturally accrues and you can find it in a peace of nature. Then you cant put a patten on it. But they sure can make it e-legal to use it cant they.

Drug companies make tens of billions of dollars from the sale of drugs. And they can only do this with drugs they can get a patten on. Because if they used natural supplements then they would be saying the supplement industry is right. Because they can not get a patten on something natural they would be open to far competition with the supplement industry and they would lose badly. So they toss billions of dollars into congress so they will help pass laws against natural supplements and in favor of drugs. This is why the drug companies hate the supplement industry. Because they know we are right. They know for a fact that natural supplements do work. They know for a fact that natural supplements "can cure anything a drug can and then some" and do it cheaper, and with less long term side effects.. The drug companies know for a fact that if the word really starts getting out they are screwed. So now they must kill the industry before its to late. The words starting to get out.


How come your doctor does not advocate natural supplements? How come every doctor you go to has got a drug for you before words even start coming out of your mouth?

Drug companies employ thousands of doctors, many from major academic centers, to go around lecturing and promoting their drugs. Thousands of university and hospital based doctors who work, promote, endorse, and lecture on behalf of the pharmaceutical industry are on the drug companies payroll. These doctors and university write all the medical journals. They do all the pub med studies, all the university studies and almost every single one of them is on the drug companies payroll one way or another.

Dozens of journals are mailed free to doctors each week. Many of the articles in these journals are written by doctors based in prestigious universities or hospitals who are paid by the drug companies to write positive things about their drugs while discounting the benefits of herbs and supplements that could be, in some cases, just, or even more beneficial at a fraction of the cost. These magazines are mailed free to doctors since the advertising dollars make a subscription fee unnecessary.


Now if thats not enough in come the drug pushers! Yes certifide legal drug dealers who in every since of the word "deal" drugs to your family care doctors.

Back in the old days, long before drug companies started making headlines in the business pages, doctors were routinely called upon by company representatives known as “detail men.” To “detail” a doctor is to give that doctor information about a company’s new drugs, with the aim of persuading the doctor to prescribe them.

My wife was worked in the medical field her whole life and has worked in many doctors offices and Hospitals. So I have gotten the chance to see today's drug reps or what is now called “pharmaceutical sales representatives,” in action. A few decades ago they were nothing more then men with little bags filled with booklets and samples. Now they come baring gifts off all kinds. Lap tops for every medial assistant in the building, a company expense card ready to take the whole team out to lunch. Pens,paper,medial equipment of all kinds you name it they have it and they will use it all to get drugs into the doctors hands so that he will push them on you..

Drug reps, in contrast, are salespeople. They swear no oaths, take care of no patients, and profess no high-minded ethical duties. Their job is to persuade doctors to prescribe their drugs. If reps are lucky, their drugs are look good on paper, the studies are clear, and their job is easy. But most of the time reps must persuade doctors to prescribe drugs that are marginally effective, exorbitantly expensive, difficult to administer, and often dangerously toxic. Reps that succeed are rewarded with bonuses or commissions. Reps that fail may find themselves unemployed.

In brief, these drug companies have a huge sales force of well-meaning but brainwashed unpaid doctors who prescribe these drugs

All in all The drug companies have everyone from top to bottom
on the pay roll. Americans pay more for drugs then anyone else in the world and the combined wealth of the top 5 drug companies is more then the General population of the entire continent of Africa and south America combined.

You will see people complain about a supplement like cell-tek and how 70% of the product the pay for is advertising. But little do they know that there best friend and bestest best buddy drug company and owner of clomid and nolvadex spends 100% more on advertising then they do on research.

It's okay for drug companies to spend oodles on advertising because they spend even more making sure their drugs are safe and effective, right? Wrong. Did you drug loving loonies hear what I just said?

http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.0050001

Sorry I have to brake the cold hard facts to you^^^^^^. But The real truth is pharmaceutical companies spend more on research than on marketing. In reality, drug companies pour $57.5 billion into marketing, dwarfing the comparably paltry $31.5 billion devoted to research.

So whats that got to do with the price of eggs you say?
Well this proves beyond a shadow of a doubt one simple fact.
The drug industry is not "research-driven, innovative, and life-saving" .

All the drug happy slappy people who run around forums all day long pushing these massages of " Its been used by doctors and pharmaceutical companies" " This study and that study and thats why the medical community has been using it" . What I am saying is to the people who are so ignorant and so blind. The people who help push this false massage that the drug companies or medical community at large even take your health into consideration are wrong. This study proves one thing. One very important fact.

A fact that every drug loving, clomid and nolva pushing, supplements are a scam, nay saying member on every single forum across the world points and says to anyone selling supplements. It proves once and for all that the drug industry is based on "market-driven profiteering."The study confirms What I have known all along. That drug companies are out to profit first, and save lives second.

So does anyone care to point at a good hard working supplement company owner and say he is only trying to make a profit and his supplements don't work. Only to turn around help sell a drug for a industry that has once and for all proven what its motives are?

I am not saying all drugs are bad. Not by any means. However I am saying that over the last few years I have worked with many people in and around the supplement industry. I have worked with people in and around the fitness industry. I have worked with everyone from Rx companies to supplement companies and steroid forum owners.

Every day I see what my friends and families lives are worth to the drug companies. I see every day how little the FDA really gives a crap about my rights, and your health. Time after time after time I see prof that every part of the drug industry is corrupt. The drug makers, the universities that make the studies, the places that should be regulating the drugs but regulate supplements more. The people that prescribe the drugs. The News magazines,the papers, and the tv channels who are paid billions buy the drug companies.

Every day over and over I am reminded of how truly corrupt and evil they the drug companies are and how they have corrupted everything and everyone around them. Now the prof is there 100% in front of everyone's eyes. There is no disputing the facts that they are profit driven. They are in the business to make money and nothing else. So much so that they spend 100% more or marketing and making money then anything else.


Now on the other hand. I see guys around me who yes of course want to make a living but they want to make a living at what they love. What they love is helping people. What they love is health and fitness. I am not talking about the big filthy rich 90 pages is every muscle mag supplement companies out there. Not talking about gnc or vita-shop or vitamin world. Although truthfully I feel They at the very least do not push products that can and have killed people just to make a profit..

They at least stop at simple pushing something that does not work as good as claimed or is over priced, but thats the worst of it. NO we have drug companies who push death in the pill and in fact have out right known that is what they were selling so they put even more advertising money behind it at times.

So the next time some prick wants to point the finger at me because I have a passion for helping people. The next time some one has the nerve to call me a "product pusher" and use the worlds like they are something negative. The next time some person who thinks he knows me and knows my real motives wants to make a filthy comment about me. I say to him, pull your head out of your behind body you have no clue what you are talking about.

Your drugs and the people behind them are the real criminals. You are a drug pusher and you and the other drug pushers are hurting peoples lives not me friend. That is what i have to say to them all and anyone who seems to have a problem with me loving what I do..

I like many other men and woman around me in this industry have a true passion for helping people. Bringing people together to share knowledge and tips that will make us all that much more healthy, bring us all to that next level of fitness. Help all of us reach what ever goals it is we want to reach be it fitness and health related or not.

I have met so many awesome people. I have met a tone of people who have good hearts and care about others. I have shared the forums of all these boards with some of the most dedicated, trustworthy, good spirited people i have ever meat in my life. Guys that would give you the shirt of there back. Like omega, and orbit (mitch) and russainstar, carl linor, Rick, Nelson, shannon, all the members of this forum of course!

I see good people all around me every where I look. Yet when I look into the eyes of the drug companies I see heartless souls filled with greed.

A lot of times when I see a person out on the forums trying to force others into there way of thinking that drugs are the only way. Often I also later find out that, that person himself always turns out to be a rather malevolent person in the end. If they don't end up getting there way or winning a discussion they almost always resort to name calling and hateful speech. Anyone in there right mind knows what kind of a person has to resort to this kind of behavior. Its not a person who really cares about others but a person who cares more about being right and getting there way. Or a person with a less then upright agenda.


It does not happen often anymore as these days many people are coming into the light and moving out of the stone ages. But there are still a great deal of ignorant people out there. When they come to attack me or the people around me I will not stand for it. I will not stoop down to there level and roll around in the mud with them. If they are not willing to have a adult conversation like the rest of us then they can move along because I am not going to entertain them and there silly ways of thinking and dealing with things.

 

[needtogetaas]

O and the man chesty trying to make a case for clomid and nolva for pct....LMAO GET THIS

I am on test for life for HRT, so does that count? Or only when I add other goodies?

says the man in post 48 of this thread.
http://www.elitefitness.com/forum/anabolic-steroids/how-long-too-long-603801-5.html#post9644061

Take his advice and you to can be on test for life!!!!!

 

[needtogetaas]

There's more to recovery than the HPTA and way way more to recovery then clomid or nolva could ever dream of covering. even if clomid or nolva were not the
piles of shit that they are. They still could not cover all one needs for pct.

Will clomid or nolvadex help with

1.Will clomid or nolvadex help with Nitrogen retention and protein+carbohydrate synthesis. Not a chance!!!
It is a well known fact steroids promote nitrogen retention in the muscles. The more nitrogen the muscles holds the more protein the muscle stores, and the bigger the muscle gets. Steroids also increase carbohydrate synthesis. More of what you eat is used as muscle fuel and energy.

2. Will clomid or nolvadex help with a Euphoria,heightened self-esteem and aggression. Fucking please we all know more then half the people taking them feel like shit
and the lucky ones might feel just ok!
This ones some what self explanatory. You feel like king of the world and life just seems great no matter what happens. Yet the moment you step into the gym you turn into a beast and kill everything in site! steroids give you this and you lose when you come off cycle. No way in hell nolva and clomids helping you get that back.

3. Will clomid or nolvadex help with Blood quality,blood volume, and muscle gorging pumps? BWAHAHAHAHAHAHAHAAAAAAAHAHAHAA LMAO you wish!!!!
Ever notice how quickly the muscle gets full when training on steroids and designer supplements? How you feel like your muscles are going to rip out of your shirt and your veins are going to pop out of your skin? That's enriched blood and blood volume. not getting that back using clomid or nolva sorry guys!!!

4. Will clomid or nolvadex help with maassive Libido,extreme sexual urges, rock hard erections? HMM some say there sex drive is "OK" or "JUST FINE" when taking them
but more people say its in the shitter. Again clomid and nolva pretty much lose on this one too. Yet another boo hoo for them!!

5. Will clomid or nolvadex help with Strength,stamina, and muscle recovery. AAAH if you think so your a meat head.
Oh yes the pounds keep adding up on the bar and we keep pushing out the extra reps. Over and over we kill it in the gym and wake up the next day ready to kill it again. <---not on clomid ya want, Not on nolva ether. You are lucky if you get to keep some of your gains and thats it.

WOW look at everything one loses when they come off a steroids or designer supplements cycle. It seems crazy to ever thing that clomid or nolvadex could cover all of this. That's because they don't. In fact they don't do anything on this list. They are old drugs once used to help recover the hpta and these days there is far better for this. The point is even if your HPTA is recovered, you're missing these vital aspects of steroid and designer supplement use.
And this is why "until now" it has been almost impossible to maintain all your gains from one cycle to the next(because retards kept pushing clomid and nolva). This is why people who take steroids and designer supplements have always taken 10 steps forward only to end up taking 5 steps back and at times losing even more then that(because retards keep pushing clomid and nolva) . Until now!!! Finally years later people are starting to see the light. Even if clomid and nolva did the job of recovering the hpta flawlessly with out causing any other problems ( we all know they do cause tuns of problems) they still dont do one single thing on this list. Not a single one of them.

But you know what does?????????????????????????????? Correctly made,purely dosed, cutting edge supplements thats what.
http://www.elitefitness.com/forum/anabolic-steroids/hcgenerate-needto-does-again-691319.html
http://www.elitefitness.com/forum/bodybuilding-supplements/hcgenerate-716865.html
http://www.elitefitness.com/forum/anabolic-steroids/hcgenerate-sent-heaven-way-needto-707933.html
http://www.elitefitness.com/forum/anabolic-steroids/my-hcgenerate-experience-687243.html
http://www.elitefitness.com/forum/anabolic-steroids/hcgenerate-needto-707157.html
http://www.elitefitness.com/forum/bodybuilding-supplements/hcgenerate-689005.html
http://www.elitefitness.com/forum/a...ate-amazing-need-some-help-advice-711743.html
http://www.elitefitness.com/forum/a...w-hcgenerate-saved-yet-another-me-704063.html
http://www.elitefitness.com/forum/a...ate-solve-my-problems-710985.html#post9544455
http://www.elitefitness.com/forum/bodybuilding-supplements/wow-hcgenerate-powerful-699719.html
http://www.elitefitness.com/forum/bodybuilding-supplements/hcgenerate-year-round-695837.html
http://www.elitefitness.com/forum/bodybuilding-supplements/hcgenerate-review-695755.html




http://www.elitefitness.com/forum/bodybuilding-supplements/problem-unleashed-689735.html
http://www.elitefitness.com/forum/b...enerate-unleashed-need2slin-worth-699173.html



and that is just one good product pulled out of many. Sure there is a lot of supplement companies out ther who make crap products thus giving supplements a bad name. Just like there are bad sources out there who sell shitty steroids and under dosed ai's.

 

[No925]

Well I went to see the specialist. And I told him about the Nolvadex "Tamoxafin" he was blown away. I had asked him if he knew of Nolvadex. His reaction was "For Breast cancer ? I explained how I used it for PCT. He couldn't believe it and laughed. He said this was the weirdest case he ever heard of. i asked what made it so weird ? He said I never heard on Men use it let a lone a well built Man. Of course he said to never use it again but he also agreed the clot had to come from the Nolvadex. He said it just didnt make sense that a 29 yr old healthy male with no family history or previous surgery could have blood clots. I am convinced that this is from the Nolva. I have taking letro ,caber , Arimedex ,clomid ,Bromo , Deca , Dbol ,Tren ,Test, Eq and Var. Something fucked me up. And after I just convinced my wife that steroids were not all that bad for you. So now here I am getting shots in my stomach sub-q , blood work every 2 days and taking warfarin Blood thinners for 6 months. I cant train because of it and I am depressed. I have put on 15 lbs in the last 3 month gained body fat and lost muscle mass. I also fucked up my back and been in pain for 6 months. I have a MRI booked next week and have to see a Osteopath in 2 weeks. My back pain is in lower back and glute. My hamstring in my left legs seems short. I cant sit with low back against the wall and put my left leg str8. It has to stay bent its fucked up. My right leg is fine. Also I cant bend to touch left foot with str8 leg.Really my biggest thing is the back pain. If I can get that fixed I will be much happier. Then goal would be to get off the blood thinners . The Dr wants me on them 3 months min. he said 50-50 chance my body will disolve the clot. If not then I need surgery.The fucking Lovenox shots I have to inject every night are $400 a shot. I live in Canada and I was fortunate to get it covered for the most part. This is a crazy time for this to be going on. Wife in school full time for her RPN , 3 kids , work ect. I think anyone that reads this post should take it serious. Tell everyone about this side effect. If I would have seen this post and knew there was a 50-50 chance of this happening I would have never used it. When I needed PCT advice a lot of the Vets on here were fast to give me Nolvadex advice and not one person steered me away. I am not blaming anyone but my self but I would hope that you guys put a stop to using Nolvadex. If some one is thinking of taking it tell them there was one guy who almost died from it and he was lucky although it put him through hell for min 6 months. I still have a cycle of test P and some var. enough test for 8 weeks and var for 4. I am hoping to still use them moderatly to catch back up when I do recover. but as far as PCT I will have to get back on doing some good research. Also I will speak to my Dr about it. Then I am done with the juice. I had just achieved my physique goal too. Well hoping to get back on track and then no more juice. its just not worth it Im all fucked up. So I hope people can learn from my mistake and I hope you guys all discourage Nolvadex from EF for life. Stay safe , stay healthy.


Banks

 

[jsl1492]

O and the man chesty trying to make a case for clomid and nolva for pct....LMAO GET THIS


says the man in post 48 of this thread.

Take his advice and you to can be on test for life!!!!!

You're being disingenuous here. Stick to the argument at hand.

The reality of the situation is that Nolvadex was the best anti-estrogen out there 20 or so years ago. But with the advent of arimidex, aromasin , and letrozole, it really should only be used
if you don't have access to the three I mentioned above. Is tamoxifen better than nothing?
IMHO, yes. I would use it if it was the only anti-E available to me because it has a proven track record.

The one thing people never mention when talking about tamoxifen is that it doesn't have the same effect on your chol/lipids as letro and arimidex. It can actually improve them (This because it is a weak estrogen itself and attaches itself to the estrogen receptors). Aromasin (at moderate dosages) also has no effect on chol/lipids, so IMHO its actually a better compound than tamoxifen. But alas, we are back to the issue of availibility. Some people might not have access to aromasin, so in their situation I would probably use tamoxifen.

 

[jsl1492]

FYI Guys: When you copy and paste something from another source, provide the link to that source.