I am 39 and yes DHEA did break me out at first ( I was taking 25 mg a day) but I managed the breakouts for the benefits. Our skin does change as we get older. I was at 174 pounds 2 months ago. I am now 151. DHEA changed the way my body reacted to food ( if that makes sense) I felt better and more energetic in the morning and those foods like ribs (my fav) just did not appeal to me. I drank 2 large glasses of water after I took the DHEA and just did not have an appetite for hours. You have to learn to balance the foods you love with what is right for you. I think women can benefit from DHEA, especially those who catch colds and feel not so good often. If 25 mg is too much a day do it every other day. I found nothing but great things from it. I even give it o my pet who is about 15 pounds overweight. It is great for the immune system.