I don't think one set of anything is going to lay you out for the count unless you have someone like Dr Ken screaming at you while you do it... I've squatted just shy of double bw for 20 in the past (at a much lighter bw than I am now) and was perfectly capable of doing multiple sets of highbar squats & leg presses shortly afterwards.
All that Darden/Jones hype about ''one set of curls making you puke'' makes me smile, if it applies to you then you desparately need on your conditioning before you have a heart attack walking from your car to the gym.
One set to failure is overrated.... I respond best to 2 exercises a bodypart, 2-3 to failure work sets of each.