i think at week 12 or so the body adjusts to the cycle. however stupid as it was i was on for almost 1 1/2 years in low dose 450 mg though at times i had many other compounds added in for shows and adding size. now its not at all healthy but i did do it. could it have caused my current pancrease issues????? so think about sides. i was competing and never went off though i have been now for a while as mentioned.