Look at all the circumstances surrounding this situation -- forget the specifics of male/female or the fact that it's Shirl (who I personally really like):
1) Married couple with "ups and downs" relationship
2) One spouse decides to go out to a bar specifically to drink and socialize (it's not like it's to entertain a customer)
3) Declares they won't be home till late (2am is late in my book)
4) Person going out is using AAS that A) Can interrupt a person's sense of attachment and B) Dramatically increase libido
5) Person going out is hanging-out with someone the spouse doesn't like specifically for possible compatibility reasons
6) Alcohol consumption is at least great enough to delay drive home
7) Person going out doesn't answer phone calls
8) Innocuous "be safe" text on person going out's cell phone the next day.
Now if we're only dealing with 1, 2, 4 or even 5 of these circumstances, it may be paranoia. But all eight?
And here's a question specifically for the ladies:
1) Picture your man.
2) Now give him a healthy dose of gear. Enough to make him edgy and really horny.
3) Now picture your arch rival. That bitch you keep coming across who doesn't like you and would screw your guy just to make a point to you.
4) Now place your guy with your arch rival at a bar with lots of alcohol involved.
Are you going to at least call him or text him, or can they do shots and have fun till 2:00am?