Well Red, there is no "exact" answer to what causes the genetic link. There are genetic links with premature atherosclerosis. Thats beyond a doubt. But, its not guaranteed, that is without a doubt as well and genetics is a funny thing. Its combinations of combinations of these genes and I am not going to explain it here.
But if there are four children. Have can have blue eyes the other half can have brown eyes. One of the blue eyed people might get the genes for heart disease and one brown eyed person. And the other set of blue eyd and brown eyed siblings just dont have it.
Genetics is a roll of the dice. You can beat genetics of course, but its still a risk factor nonetheless. It is a reliable indicator of the chance of them having heart disease based on family history. Its just a fact.
If a person has no family history, well its unlikely they will have premature atherosclerotic disease.
THere are some with real bad genetics that if they just ate grasshoppers and plants, theyd still have heart disease b/c they picked their wrong parents. Same exact family history, the person smokes, has diabetes, high blood pressure. THen we do an angiogram and they have clean arteries.
THere is no exactness to the disease. thats the main problem and why all the testing is done.
Now, I know exactly the disease process how it works, what it looks like under a microscope, what an angiogram looks like
The treatments and meds are what I know.
And I can tell you this, without a reason of doubt in my mind is that only meds prevent heart attacks. Stents do not, they treat symptoms, CABG and I believe in evidence medicine do increase length of life,antithetical to stents which CABG is major surgyer and the grafts fail.
But according to the science that currently is accepted. Intervention does not prevent heart attack. The drugs prevent heart attack. The 4 drugs I metioned and you can fiddle with some other stuff as well.
And as far as the philosophy of once you start them, then you dont stop them.
Thats the philosophy of physicians. If a patient is on them, dont take them off.
I talked to several endricrinologists about menopausal HRT and the one speaker at the conference summed it up.
"Dont put them on it and dont take them off of it"
Thats a bit different than the cardiac guidelines but its pervasive to not change drugs proven to lower risk in people if they tolerate the side effects.
There is no "one size fits all exact answer" to this
Each patient should be assessed and treated to the appropriate guidelines based on an evidence-based medical algorhythm.
If yes or no, then proceed here to this appropriate therapy. Often its just a game of running several tests to get the root cause.
You cant say genetics is right or wrong all the time. A genetically prone person who gets diabetes from obesity, does not exercise and smokes. Is MUCH higher to get coronary artery disease, than say a obese diabetic who smokes and doesnt exercise but DOES NOT have a family history.
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As my old professor used to say in medicine when asked a question "Always, Sometimes, Never Maybe!" in response. I cant help but say that now