^ Would love to see you review it if you decide to use it!
That's a fair request and I will absolutely do so if I buy some!
does anyone know when HCGenerate will be back in stock?
I haven't tried it, so please don't think I am talking shit on it. It seems to have good reputation around here, so I take that to mean something.
Based on the name, and it's marketed use as Post Cycle treatment, I expect it to mimic HcG. But it's more expensive than actual HcG. So....I don't get it.
The hypothalamus, upon realizing that blood levels of androgens are low releases Gonadotropin Releasing Hormone (GnRH). GnRH goes to the pituitary which takes this hormone as the stimulus to release Lutenising Hormone (LH). LH then goes to the testes and stimulates T production. HCG mimics LH however it is not LH!!!!!!!
The HCG would stimulate more T to be released. but during a cycle the hypothalamus would still "recognise" the increased level of androgens and still stop releasing GnRH which in turn would lead to the pituitary stopping your own natural production of LH.
This wouldn't matter so much whilst you were taking the HCG as this replaces the LH and so T production would continue whilst you kept taking the HCG. So although Hcg may prevent degeneration of the ladeg cells (remember that your own body isn't producing any LH or GnRH anymore!!! regardless )
As the hypothalamus recognizes outside sources of both androgens and LH now it will feather suppress its own production of LH and GnRHThe problem is that whilst the pituitary has been lying dormant due to not receiving any GnRH from the Hypothalamus it atrophies (just like the testes do when not used).
Get it?
In a normal healthy male luteinizing hormone (LH) and follicle stimulating hormone (FSH) are sent from the brain (the pituitary) to stimulate the testes to make testosterone and sperm.
The release of LH & FSH from the pituitary is stimulated by Gonadotropin Releasing Hormone (GnRH) from the hypothalamus. The hypothalamus is stimulated to produce GnRH when it senses low levels of testosterone and estrogen.
(hypothalamus [GnRH] --- > pituitary [LH & FSH]--- >(hcg would be placed here if we placed it anywhere)---> testes [testosterone])
So although hcg may cause there to be less atrophie of the ladeg cells it in turn causes more atrophie of the pituitary.
ingredients in hcgenerate -- increases testosterone production by preventing the negative feedback of testosterone and estrogen on the hypothalamus through GABAergic modulation though. And although researchers are just beginning to understand how the GABAergic system regulates the hypothalamus and GnRH secretion its important to know that a lot more studies have been done and are getting done then you think.. On Natural ingredients!!! Like phytoserms one can find in products like hcgenerate and phytoserm-347
Now I am not saying that preventing the desensitization of the ladeg cells during a cycle is not a good thing. Because as we know No matter how much LH & FSH the brain secretes, the testes won't secrete testosterone if they are desensitized to LH & FSH. (remember, this can happen from too much, or not enough LH & FSH stimulation)
hCG’s effect is centralized at the Leydig cells of the testicles and stimulates hormone function at the testicular level but does not reverse hypothalamic-pituitary suppression. Adequate stimulation from pituitary gonadotropins is required for the Leydig cells of the testicles to function independently in the body’s normal hormone axis.
of course during a cycle there are natural compounds and products that work through different mechanisms to prevent complete shutdown with out feather suppressing pituitary some through GABAergic modulation and some through others like with hcgenerate.
Bio-identical/Homeopathic hormones are plant-derived and identical to the body's hormones. They are naturally the exact same thing and or they cause "natural" production/suppression of the target hormone.
Synthetic hormones such as hcg or a drug like serm are similar but not identical to the body's hormones. Fethermore they are "always" a outside source of the parent/target hormone. Moreover through manipulation of the hormone cascade they can also be used to suppress the production of a target hormone in the hopes to facilitate the production of another. We use compounds like Hcg and or clomid often notwithstanding the fact These slight chemical shift create a mismatches between the body's receptors ,Parent hormones,sister hormones, and or governing hormone cascade.
Now don't pull out your pitch forks and torches just yet![]()
I love my steroids,drugs,chemical enhancement just as much as the next guy and in fact IMO more bwahahahahaaaa . So lets not try and act like I am downing there use. On the contrary I just happen to be more of a nonconformist who believes that Both Natural and synthetic coexist synergisticly in many concomitant circumstances.
Bio-Identical or Homeopathic . One naturally augments or reduces and the other Naturally replaces. Although all things considered Naturally replacing is often (but not always) the superior. This creates less of a problem in the way of mismatching, adverse reactions, or suppression then the chemical counterparts.
Weather Fadogia agrestis method of action is more of a Bio-Identical or a Homeopathic Is somewhat unfounded however its actions through what ever Natural Mechanisms is founded. Through both scientific and real world results/feed back.
Title: Aphrodisiac potentials of the aqueous extract of Fadogia agrestis (Schweinf. Ex Hiern) stem in male albino rats.
Author: Yakubu MT , Akanji MA , Oladiji AT
Source: Asian J Androl, 7(4): 399-404 2005
Abstract: AIM: To evaluate the phytochemical constituents and the aphrodisiac potential of the aqueous extract of Fadogia agrestis (Rubiaceae) stem in male albino rats. METHODS: The aqueous stem extract of the plant was screened for phytochemical constituents. Male rats were orally dosed with 18 mg/kg, 50 mg/kg and 100 mg/kg body weight, respectively, of the extract at 24 h intervals and their sexual behavior parameters and serum testosterone concentration were evaluated at days 1, 3 and 5. RESULTS: Phytochemical screening revealed the presence of alkaloids and saponins while anthraquinones and flavonoids are weakly present. All the doses resulted in significant increase in mount frequency, intromission frequency and significantly prolonged the ejaculatory latency (P 0.05) and reduced mount and intromission latency (P 0.05). There was also a significant increase in serum testosterone concentrations in all the groups in a manner suggestive of dose-dependence (P 0.05). CONCLUSION: The aqueous extract of Fadogia agrestis stem increased the blood testosterone concentrations and this may be the mechanism responsible for its aphrodisiac effects and various masculine behaviors. It may be used to modify impaired sexual functions in animals, especially those arising from hypotestosteronemia
http://www.elitefitness.com/forum/anabolic-steroids/hcgenerate-needto-does-again-691319.html
http://www.elitefitness.com/forum/bodybuilding-supplements/hcgenerate-716865.html
http://www.elitefitness.com/forum/anabolic-steroids/hcgenerate-sent-heaven-way-needto-707933.html
http://www.elitefitness.com/forum/anabolic-steroids/my-hcgenerate-experience-687243.html
http://www.elitefitness.com/forum/anabolic-steroids/hcgenerate-needto-707157.html
http://www.elitefitness.com/forum/bodybuilding-supplements/hcgenerate-689005.html
http://www.elitefitness.com/forum/a...ate-amazing-need-some-help-advice-711743.html
http://www.elitefitness.com/forum/a...w-hcgenerate-saved-yet-another-me-704063.html
http://www.elitefitness.com/forum/a...ate-solve-my-problems-710985.html#post9544455
http://www.elitefitness.com/forum/bodybuilding-supplements/wow-hcgenerate-powerful-699719.html
http://www.elitefitness.com/forum/bodybuilding-supplements/hcgenerate-year-round-695837.html
http://www.elitefitness.com/forum/bodybuilding-supplements/hcgenerate-review-695755.html
http://www.elitefitness.com/forum/bodybuilding-supplements/props-n2bm-hcgod-like-sex-720583.html
http://www.elitefitness.com/forum/a...perience-hcgenerate-formastanozol-722309.html
A cut and past of what I wrote in a different thread but most of it applies here in this thread.
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