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Green Goblin
New member
Hello all. I just fininshed reading a new study conducted by scientists at the University of Kansas (published in J IREPR RES (2002) 15:1233-1243). The goal of the study was to enhance the absorption of trenbalone acetate, maximizing the weight gain and growth potential of feedlot cattle. Now this is going to sound strange, but it is scientifically sound.
The research team compared 1) inserting one 200 mg trenbalone acetate pellet per 200 kg heifer weight (Finaplix-H) into the rectum of the cattle with 2) direct intramuscular injection of trenbalone acetate, done at 1 mg/kg. The results were amazing! Three-fold higher AUC's were obtained for the suppository form compared to direct injection. (AUC is "area under the curve" for non-pharmacologists -- it is a measurement of a compound in plasma that takes into account both serum concentration AND amount of time the compound is present. The formula for this is c^n X t; concentration raised to n-power X time, where n is Sanford's constant (a little complicated to explain in this message)) The group claims that duration of exposure is as important as peak plasma levels, a common phamarmacologic paradigm. The explaination for this increased exposure is the extreme vascularity of the rectum, especially at the juncture where the rectum joins the colon. The time-released trenbalone was very readily absorbed at this site. Direct intramuscular administration resulted in relatively fast (1 hour) peak plasma concentrations, but clearance of the compound was fast, with a half life of only 284.7 minutes post-peak. The suppository group had a lower, but pharmacologically effective, concentration for an incredible 6.5 days. So the bottom line is this: using this model system, one might predict that using trenbalone pellets as a suppository would give better results than converting it to an injectable form. Humans share the vascularity of the upper rectum. This very convenient route of administration would prevent a possible loss of precious product in the conversion process as well! AND... one would only need to place a couple of pellets up there once a week... and NO MORE DAMN NEEDLES!! I am going to give this thing a try and will update all of you when the results are in.
The Green Goblin
The research team compared 1) inserting one 200 mg trenbalone acetate pellet per 200 kg heifer weight (Finaplix-H) into the rectum of the cattle with 2) direct intramuscular injection of trenbalone acetate, done at 1 mg/kg. The results were amazing! Three-fold higher AUC's were obtained for the suppository form compared to direct injection. (AUC is "area under the curve" for non-pharmacologists -- it is a measurement of a compound in plasma that takes into account both serum concentration AND amount of time the compound is present. The formula for this is c^n X t; concentration raised to n-power X time, where n is Sanford's constant (a little complicated to explain in this message)) The group claims that duration of exposure is as important as peak plasma levels, a common phamarmacologic paradigm. The explaination for this increased exposure is the extreme vascularity of the rectum, especially at the juncture where the rectum joins the colon. The time-released trenbalone was very readily absorbed at this site. Direct intramuscular administration resulted in relatively fast (1 hour) peak plasma concentrations, but clearance of the compound was fast, with a half life of only 284.7 minutes post-peak. The suppository group had a lower, but pharmacologically effective, concentration for an incredible 6.5 days. So the bottom line is this: using this model system, one might predict that using trenbalone pellets as a suppository would give better results than converting it to an injectable form. Humans share the vascularity of the upper rectum. This very convenient route of administration would prevent a possible loss of precious product in the conversion process as well! AND... one would only need to place a couple of pellets up there once a week... and NO MORE DAMN NEEDLES!! I am going to give this thing a try and will update all of you when the results are in.
The Green Goblin
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