Well after first injection with the 22g, i have a pretty bad knot. I injected wed night. Thursday was sore as hell. But seemed to loosen up after a long walk that day. Today the pain was not as bad, but i noticed some redness about two inch's above (by above i mean moving towards my head) Not towards my knee like i have red about. But the knot is the same thing its about 2 inch's above my injection site. Now i dont know if this redness was caused of me continually touching it while i was walking today. But also its a bit warm to the touch. But keep in mind this is all going on 2 inch's above the injection. I shot into my quad BTW.