Please Scroll Down to See Forums Below
**2 FREE Bottles of Omnibolic(O-Bol)!**
- Thread starter Ross
- Start date
LiquidPhire
New member
221 228
Basic_wonder
New member
113
L
lartinos
Guest
3, if the stuff works I'm sure it will sell.
needtogetaas
New member
8675309
navigatorrs
New member
418
shottabiggs
New member
278
17 368
Ross said:
Supreme Sports Enhancements is utterly dedicated to SCIENCE, because real science equals real results.
Supreme Sports Enhancements is NOT your average supplement company with your average product line. We specialize in the conception and formulation of highly unique and effective bodybuilding products that are SCIENTIFICALLY PROVEN to work. If you are tired of wasting your hard-earned money on the same old ineffective garbage, have no fear....SSE is here!
I have chosen 2 numbers between 1-500. The member(s) who guess each number will each win 1 FREE bottle of Omnibolic
Rules:
- Each member may guess as many times as possible.
- Each member must wait 45 seconds before posting again.
- Each post can only contain one number guess.
- If two members guess the same winning number, the member who guessed first will win.
- Have FUN!
The active anabolic ingredient in Omnibolic is the known steroid, Ecdysterone. Imported directly from Russia, the Ecdysterone in this product is extracted from Rhaponticum carthamoides and is guaranteed to be 98% (or higher) pure. This (and only this) remarkable plant extract, (at this potency), has been proven in numerous clinical studies to be more anabolic than methandrostenolone (Dianabol), with no androgenic or other undesirable side effects. Omnibolic is a non-hormonal dietary supplement that will cause a huge increase in anabolism but will not effect hormone levels.
Omnibolic works by increasing nitrogen retention and increasing protein synthesis at the cellular level (for this reason we strongly recommend that you increase your daily dietary intake of protein while using this product). It has been scientifically proven, without a doubt, that increased nitrogen retention and resistance training will stimulate muscle growth and burn fat as much as 20 times more effective than without the increase in nitrogen retention caused by ecdysterone supplementation.
The Russian ingredients in Omnibolic have also been clinically proven to increase in strength and endurance. This is the same exact ingredient that the Russian government gave to its athletes prior to competitions in order to optimize performance while coming off anabolic steroids to beat doping tests. Strangely enough, many Russian athletes performed better in competition while using Ecdysterone than they did in preparation while on anabolic steroids.
If you are wondering why you have never heard of Ecdysterone before it is because this information has been somewhat classified until the collapse of the Soviet Union and since then it has been way too expensive (over $20,000 a kilo) to bring real Ecdysterone from Rhaponticum carthamoides to market. UNTIL NOW!
This is the first time ever that this material is being made available and you have our guarantee that nothing you have ever tried will work better than Omnibolic for adding lean muscle mass. Because Omnibolic is a non-hormonal supplement it can be safely used by both men and women. The Ecdysterone in this product is Ecdypure TM material, guaranteed to be 98% or higher pure Ecdysterone. Omnibolic will not cause a positive test result for any banned or controlled substance. Omnibolic is a 100% safe and legal dietary supplement.
Ecdysterone has also been shown to be an adaptogen. This basically means that it has other physiological advantages in addition to increasing muscular development. Part of the advantage of this product includes an increase in mental, physical and immunological capacity. The pioneer studies were conducted by Professor Vladimir Syrov of the Research Institute of Plant Substance of Chemistry, Academy of Science of Uzbekistan, and specifically proved that the ecdysterone derived from Rhaponticum carthamoides possessed anabolic properties in both animals and humans. His original work was done primarily with Rhaponticum carthamoides.
6-Keto Diosgenin (25R-Spirost-4-ene-3,6-diol)
Dr. Syrov and Dr. A.J. Kurmukov published a study entitled, "The Experimental Study of the Anabolic Activities of the 6-Keto Derivatives of Some Natural Sapogenins", in which they analyzed the various sterol compounds from these plant sources. They found several adaptogens in addition to the beta-ecdysterone, including agigenin, disogenin and alliogenin, all of which displayed further anabolic activity, but none of which displayed androgenic properties. This basically means that this group of sapogenins do not have any influence in elevating or decreasing the testosterone levels of the person taking them. This is precisely what the Russians wanted, since they were having several of the world class athletes fail urine tests in international competition because they were taking synthetic steroids. What Dr. Syrov and his colleagues further showed was a dramatic improvement in liver, kidney, heart and muscular activity, and a dramatic increase in the total amount of protein found within these organs. In other words, there is an increase in protein synthesis in all of the major organs of the body, including muscular tissue, with no effect on the hormonal activity of the body. This is remarkable and exciting because it thus poses no threat to the individual in terms of toxicity and/or the capacity to increase existing cancers. As a matter of fact, several South American physicians have used this compound extensively to battle cancer and even a very difficult disease known as Chronic Fatigue Syndrome, which is normally considered to be a viral infection.
How Does Ecdysterone Work?
In each cell there are 3 forms of ribonucleic acid (RNA) which are involved in the production of protein. All of this protein synthesis occurs at the level of the ribosome. Basically, the process involves 3 states:
1. Ribosomal RNA (rRNA) gives instructions to the poly-ribosomal complex to join together specific ribosomes into forming a complex (group). This is the manufacturing facility where the proteins and muscle tissue are formed.
2. Messenger RNA (mRNA) travels from the nucleus where it has received the specific genetic code on how to make a specific protein. This is very much like a reel-to-reel tape going through a computer in which specific instructions are being given at an extremely rapid rate. The mRNA travels into the poly-ribosomal complex and runs across the ribosomes, giving specific instructions which result in exact sequences of the 22 different amino acids being placed together to form a specific protein (muscle).
3. Transfer RNA (tRNA) then move the amino acids to the ribosomes so as to allow the mRNA tape to hook up the individual amino acids to form the polypeptides (protein chains).
Realize that the Russian and Japanese scientists determined the specific location of Ecdysterone's actions were at the level at which the transfer RNA translates amino acids into proteins at the ribosomes. Thus, Ecdysterone increases the rate at which proteins are manufactured. Synthetic steroids affect the instructions from the nucleus, called transcription. This can pose a problem in that, if one has hormonally sensitive cancer, it can increase the rate of cancer growth within the body. Ecdysterone, on the other hand, affects the translation of amino acids into protein, which does not influence the rate of growth of cancers. This makes the Ecdysterone products totally safe, having no effect on the hormonal levels of the body. Researchers have proven that beta-ecdysterone has no side effects, except that it improves liver function, kidney function, heart function, muscle size and physical performance. Because of the other sapogenins within the herbal complex there may even be other medicinal benefits which can help an individual, such as anti-viral, anti-bacterial and immune stimulating properties.
Citrulline Malate
Citrulline, although a non-essential amino acid, is not widely abundant in our daily diet. However, it plays a vital role in many important biological processes.
1. Increased NO Production
Of specific interest to all of us athletes in the trenches is it's role of regulating Nitric Oxide (NO). I mention this first only because the sport nutrition industry has been recently flooded with NO potentiating products comprised of L-Arginine and / or other Arginine salts, which until this day have been the most cost effective manner in improving NO function. It is well known in the scientific community that L-Arginine is a substrate for production of Nitric Oxide2, as well as catalyst for other metabolic reactions including its effects on insulin, various hormones and creatine synthesis.3
(The NO synthase (NOS) enzymes convert Arginine into Citrulline and NO)
So what is NO and what can it do for you? Nitric oxide is the cell-sign****g molecule that has a part in regulating blood flow, oxygen delivery, glucose uptake, muscle firepower, and muscle growth. Obviously the ability to control these physiological effects can be of tremendous value to athletes.
Unfortunately I think many of the companies currently marketing NO products are missing the boat by not including Citrulline Malate in the current crop of NO supplements. You see, many of Citrulline's functions stem primarily from its ability to increase plasma levels of Arginine endogenously (in the human body).4 And what is really so exciting about Citrulline is that it seems to increase plasma Arginine levels better than taking the amino acid Arginine itself.5 You read correctly!
Research has shown that supplementation of Citrulline raises Arginine levels more effectively than taking the same dose of straight Arginine. Keep in mind that Citrulline Malate's NO enhancing properties are just one of the unique benefits this nutrient offers to athletes. And if the enhanced pumps and improved nutrient delivery properties are the reason you are using Arginine based NO products, you need to pay attention to Citrulline Malate.
2. Reduces Lactic Acid and Ammonia
Here is something else you need to know about Citrulline... it is an intermediate in the Urea Cycle. The Urea Cycle is a system in the liver of carrier molecules and enzymes that convert nitrogenous wastes into urea and eliminates them from the body. The production and removal of urea is essential for the elimination of ammonia and toxic nitrogen metabolites. Ammonia is extremely toxic to all cells and excessive levels may even be fatal. Even in healthy athletes, the build up of ammonia can lead to extreme fatigue and more.6 It also reduces glycogen formation, and inhibits the energy cycle. Obviously this is what every athlete wants to avoid!
Unfortunately all exercise, anaerobic and aerobic exercise produces tons of this stuff.7 Ammonia also forms when bacteria in the intestinal tract breaks down protein. The point is that the more ammonia in your blood, the poorer your athletic performance.8 Citrulline Malate comes to the rescue once again by aiding in the elimination of amino acid byproducts of protein metabolism. Researchers also purpose that Citrulline Malate may help to eliminate the burn associated with lactic acid build up as well as reduce the negative effects of ammonia and bacterial endo toxins on performance. Demonstrations also show Citrulline Malate as having a protective effect against acidosis and ammonnia poisoning.12 The metabolic actions of Citrulline Malate clearly explain the anti-fatigue properties in man and shows great promise to its uses as a performance enhancer for athletes.
The Urea cycle splits Arginine into Ornithine and Urea. The urea is excreted as a waste product. Citrulline is synthesized from the Ornithine and carbamoyl phosphate. Citrulline is then converted back to Arginine.
3. Increases ATP and Phosphocreatine Recovery
No doubt there is a lot to get excited about when it comes to the performance enhancing potential of Citrulline Malate and how it works. Another study showed yet another way Citrulline Malate can benefit athletes - by increasing aerobic energy production.9 Studies show subjects using Citrulline Malate have an increase in the rate of muscle ATP (Andenosine Triphosphate, the major energy source within the cell) production during exercise and greater phosphocreatine recovery after exercise. So taking Citrulline Malate may result in muscles that can keep on going and going... completely smashing the aerobic threshold! These effects are more than likely mediated by the malate portion of the Citrulline Malate compound, which is a Krebs Cycle intermediate.
The Krebs Cycle refers to a portion of the metabolic pathway of amino acids in the conversion of sugars and fats into ATP, and the role of friendly bacteria (mitochondria) in our cells. The Krebs Cycle happens in the mitochondria, where sugar and fat pour in and are burned much like in a blast furnace, with a number of weak amino acids acting as a conveyor belt. Impaired ability to make ATP results in premature fatigue and "hitting the wall", unable to continue intense exercise.
Getting back to malate, it appears that it is synergistic when bonded to citrulline and this peptide may work better than supplementation of citrulline alone.10 While citrulline acts to increase NO and reduce performance inhibiting metabolic toxins, malate conditions the recycling of lactate and pyruvate, and takes part in the kreb cycle supplying instant and sustained energy.
Scientific Studies
Ecdysterone has been tested for its effects on work capacity, immune function, lean body mass and fat loss, among other variables in a number of scientific studies. The vast majority of research indicates an increase in test subjects' lean mass. Results were further improved when ecdysterone was consumed with protein.
Increase Protein Synthesis and Invoke Positive Nitrogen Balance:
Studies conducted in the Soviet Union in 1988 showed ecdysterone helps "increase hepatic protein synthesis and subsequently promote positive nitrogen balance!" How does this lead to more muscle mass? Simply: "the more nitrogen your body maintains and the greater rate of protein synthesis, the more mass, period." How, exactly, does ecdysterone do this?
V. Smetanin, researcher of the Smolenk State Medical Institute in Russia speculates that ecdysterone decreases urea concentration in the body and increases hemoglobin levels by increasing a process called erythropoiesis. Erythropoiesis is the development of mature red blood cells. This leads to a stimulation of the anabolic process in protein metabolism, which in turn leads to a positive nitrogen balance in the body.
Increase Lean Muscle Mass While Reducing Body Fat:
The most often quoted ecdysterone scientific study was published in Scientific Sports Bulletin by S. Simakin in 1988. The objective of Simakin's famous study was to determine the effect of ecdysterone on muscle tissue mass and fat mass, while testing for hormonal changes in the subjects.
For the study, three control factors were used: a placebo, protein, and ecdysterone with protein. The results were significantly in favor of the third factor. Of the 78 highly trained male and female athletes who consumed just protein, they showed only a slight increase in muscle mass for the 10 day period of time.
Those who used a placebo lost a slight amount of lean muscle, while those who used protein plus ecdysterone showed a 6-7% increase in lean muscle tissue with nearly a 10% reduction in fat! Let me say that again: A 10% reduction in fat and a 7% increase in lean muscle tissue in just 10 days! Safety testing was conducted during the same time period which showed no difference in hormonal balance. Wow, if ecdysterone plus protein can do this for highly trained athletes, just think what it can do for the average person!
Increase Stamina, Endurance, And Energy:
Ecdysterone was tested in another study performed in 1986 by B.Ya Smetanin. For this research, 117 highly trained speed skaters between the ages of 18 and 28 were tested for work capacity, body weight, lung capacity and VO2 max. The results speak for themselves: all of the said parameters increased as well as an increase in the O2 pulse max and an increase in the exhalation of CO2.
Basically, they received more oxygen to their cells! This equates to decreasing recovery time, maximizing performance, permitting optimal muscle anabolism and maximum fat reduction. It also means the athletes using ecdysterone compared to those on a placebo experienced increased stamina, endurance and energy.
That's not all! A study conducted using 112 athletes performed by B.G. Fadeev in Russia showed some very impressive overall results. However, by this time, the results should come as no surprise. 89% of those who supplemented with ecdysterone versus a placebo reported less fatigue, greater performance, more motivation, greater speed, and improved strength. How long did it take before these athletes reported these effects? Months? Weeks? No, five days. To make matters even better, no adverse side effects were reported.
Ecdysterone compared to methandrostenolone (D-Bol):
The action of methandrostenolone and ecdysterone on the physical endurance of animals and on protein metabolism in the skeletal muscles.
Author:
Chermnykh NS ; Shimanovski¨i NL ; Shutko GV ; Syrov VN
Farmakol Toksikol, 51(6):57-60 1988 Nov-Dec
Abstract:
The results of the comparative study on the myotropic activity of methandrostenolone and ecdysterone and their effects on physical endurance of animals suggested that ecdysterone possessing a wider spectrum of the anabolic action on the contractile proteins of the skeletal muscles exerts a more pronounced influence on physical endurance of animals without their preliminary training.
This study shows anabolic effects with no androgenic effects as compared to D-bol:
Anabolic activity of phytoecdysone-ecdysterone isolated from Rhaponticum carthamoides.
Author:
Syrov VN ; Kurmukov AG
Farmakol Toksikol, 39(6):690-3 1976 Nov-Dec
Abstract:
Introduction of phytiexdizone-exdisterone (0.5 mg/100 g) to rats for 7 days is shown to be attended by an accelerated body weight gain and also by a rising weight of the liver, heart, kidneys and musculus tibialis anterior. In these organs the total amount of protein increases. All of the above-stated changes are more marked when the substance is given to growing rats (70--80 g). In experiments on castrated sexually immature rats the androgenic action of exdisterone, unlike that of methandrostenolone, is not demonstrable.
Positive insulin response:
The effect of nerobol and ecdysterone on insulin-dependent processes linked normally and in insulin resistance
Author:
Kosovski¨i MI ; Syrov VN ; Mirakhmedov MM ; Katkova SP ; Khushbaktova ZA
Probl Endokrinol (Mosk), 35(5):77-81 1989 Sep-Oct
Abstract:
The effect of substances with anabolic activity (metandienone and ecdysterone phytoecdysteroid) on the manifestation of insulin effects was studied on a model of insulin resistance in rats induced by injections of hydrocortisone or by insulin insufficiency caused by alloxan. The sensitivity of the body to i. v. infusion of insulin and the reactivity of isolated fatty tissue to the hormone were increased after administration of these substances to test animals. The above effects of steroids were determined by nonspecific synthesis of total proteins in cells rather than by an increase in insulin secretion.
Also a very very strong adaptogen and antioxidant:
Antioxidant effect of 20-hydroxyecdysone in a model system
Kuz'menko AI - Ukr Biokhim Zh - 1999 May-Jun; 71(3): 35-8
Original Title:
Izuchenie antiokislitel'nogo effekta 20-gidroksiekdizona v model'noi sisteme.
Abstract:
Changes in the level of lipid free-radical oxidation in mitochondrial fraction at the presence of 20-hydroxyecdysone in 1, 2, 4, 6, 8 microM concentration with the help of a chemiluminescence (ChL) method were investigated in vitro. Statistically authentic reduction of ChL kinetic parameters--I(s) and tg alpha, at 20-hydroxyecdysone presence in concentration of 2 microM was found. 20-hydroxyecdysone administration in concentration 4 microM and more leads to the statistically authentic change of all four ChL parameters. The antioxidizing effect of 20-hydroxyecdysone was compared with action of such antioxidant as a hydroquinone. The higher activity of 20-hydroxyecdysone as an antioxidant in comparison with the hydroquinone was shown. For changes of all four measured kinetic parameters of ChL, concentration of the hydroquinone as much 2-fold than for 20-hydroxyecdysone is necessary. On the basis of our researches in the model system a conclusion was made that 20-hydroxyecdysone has an antioxidizing action on lipid free radical oxidation in mitochondrial fraction in dependents on concentration. 20-Hydroxyecdysone has antioxidizing properties directly, in these conditions in vitro, when its metabolites formation does not occur yet.
Insect hormones in vertebrates: anabolic effects of 20-hydroxyecdysone in Japanese quail.
Slama K - Experientia - 1996 Jul 15; 52(7): 702-6
Authors:
Slama K; Koudela K; Tenora J; Mathova A
Abstract:
Ecdysteroids are hormones controlling cell proliferation, growth and the developmental cycles of insects and other invertebrates. They are occasionally present in various unrelated plants for no apparent reason; no phytohormonal function has yet been identified. In certain cases, ecdysteroids are accumulated to high levels in leaves, roots or seeds. Some ecdysteroid-containing plants have been known as medicinal plants for centuries. One of them, Leuzea carthamoides Iljin (Asteraceae), growing in Central Asia, contains 0.4% ecdysteroid in dry roots and 2% in seeds. A pharmacological preparation from this plant, "Ecdisten', is already available as a commercial preparation for its anabolic, tonic and other effects, for medical use (review). It remained problematic, however, whether ecdysteroids were truly responsible for these effects, because Leuzea contains a number of other biologically active compounds in addition to ecdysteroids. We extracted and purified ecdysteroids from the seeds of Leuzea. With 6 g of 96% 20-hydroxyecdysone (20E), we made a large-scale feeding assay with Japanese quail to find out whether ecdysteroid alone could duplicate the anabolic effects of the seeds. We found that the 96% ecdysteroid increased the mass of the developing quails in a dose-dependent manner, with the rate of increase proportional to the ecdysteroid content in the seeds; there was a 115% increase in living mass with 100 mg kg-1 of pure 20E compared with 109.5% increase with 100-180 mg kg-1 20E equivalents in the seeds. We conclude that the plethora of growth-promoting, vitamin-like effects induced in vertebrates by Leuzea is mediated by ecdysteroids.
Study demonstrating the Anabolic effect of 6-Keto Diosgenin
[Experimental study of the anabolic activity of 6-ketoderivatives of certain natural sapogenins][Article in Russian]
Syrov VN, Kurmukov AG.
It is shown that 6-ketoderivatives of natural sapogenins, viz. agigenin, diosgenin and alliogenin, display the anabolic activity and do not manifest any androgenic properties. The compoud IV/(25 R)-5alpha-spirostan-2alpha, 3beta, 5alpha-triol-6-OH/produces an accelerated gain of weight in rats, and also an increase in the weight of the liver, heart, kidneys, musculus tibiliasis anterior and augments the total amount of protein therein. All of the above-mentioned changes become more pronounced with the study substance introduced to young animals. Castration of sexually immature rats greatly mitigates the anabolic effect of the compound IV.
PMID: 1028596 [PubMed - indexed for MEDLINE]
splperformance
New member
11 365
splperformance
New member
for shits n giggles we'll also throw 57 and 411 out there...im done
needtogetaas said:
Hey thats my girlfriend Jennys number, WTF!!!
Donnie Darko
Lurking Around
I remember reading in this thread that BB was bashing Ross or his products, however, BBdotcom has similar write-ups on the same or most of the same ingredients in their articles. They may not state numbers or percentages, but even they use claims such as "drastic, dramatic, etc..." Several years ago, Syntrax came out with a product that contained mainly Ecdysterone and touted it similarly and I had always considered Syntrax as good. Why not give Ross's products a shot? I think needto mentioned that he'd like to see threads that go on for pages concerning my products, but I tend to be squeamish about conflict. Nothing can do the same thing that steroids can do, but in some respects, legal supplements do have great advantages if you don't like being sodomized by a cell mate named Bubba for instance.
I know that ceo doesn't particularly ascribe much to some or alot of the products sold here at EF because he seems like someone who prefers to hit his genetic limit more naturally. Everyone with solid discipline and who know their bodies really well, can get those results, but there are always people in the world who want to get there a little more quickly. Some want to get there more quickly and do so with steroids, and some want to get there more quickly, but more safely (either legally or for health reasons). As long as we can help people get to their limits more quickly without harming them, then that is why we are here...well...that and make money too (can't lie about that since we all have to eat and try to make a living doing what we enjoy).
Aside from any claim that he or I or anyone would ever make, research at least the products if nothing else for what they can do without anyone tell you what they say their own products can do. I know that not everyone would read the Bible, but it does have some very good wisdom in it from time to time and that would be like what Paul said about how he wished everyone was like the Bereans....searching the scriptures daily to see if someone's claims are true. My own fat loss products won't necessarily work like I would claim them to work if people take them, sit on the butts all day and eat pork like it was their patriotic obligation.
Give his stuff a try and post your own results. Give my stuff a try and post your own results. I imagine that every sponsor on this board started off with people being a little leary about their products at first.
I know that ceo doesn't particularly ascribe much to some or alot of the products sold here at EF because he seems like someone who prefers to hit his genetic limit more naturally. Everyone with solid discipline and who know their bodies really well, can get those results, but there are always people in the world who want to get there a little more quickly. Some want to get there more quickly and do so with steroids, and some want to get there more quickly, but more safely (either legally or for health reasons). As long as we can help people get to their limits more quickly without harming them, then that is why we are here...well...that and make money too (can't lie about that since we all have to eat and try to make a living doing what we enjoy).
Aside from any claim that he or I or anyone would ever make, research at least the products if nothing else for what they can do without anyone tell you what they say their own products can do. I know that not everyone would read the Bible, but it does have some very good wisdom in it from time to time and that would be like what Paul said about how he wished everyone was like the Bereans....searching the scriptures daily to see if someone's claims are true. My own fat loss products won't necessarily work like I would claim them to work if people take them, sit on the butts all day and eat pork like it was their patriotic obligation.
Give his stuff a try and post your own results. Give my stuff a try and post your own results. I imagine that every sponsor on this board started off with people being a little leary about their products at first.
Donnie Darko
Lurking Around
Actually, I posted this in the wrong thread. My post was meant for the other thread. I suppose I can copy and paste.
Donnie Darko said:
Well said, spoken like a true gentlman.
splperformance
New member
and the winner is______________________________??????????????????
DJLegacy2k1
New member
ROSS will announce a winner when these threads are the most posted on...publicity stunts rock!
-Legacy
-Legacy
splperformance
New member
DJLegacy2k1 said:
ooooooooo i see
3.1415926535 8979323846 2643383279 5028841971
Pat_McCrotch
New member
187
makeingains
New member
20
DJLegacy2k1
New member
BWHAHAAHHA, just wanted to see what ROSS has to say now....Theres no MISSING numbers or CLOSE CALLS now lol.
1 to 500, I list EVERY NUMBER....So I win by default now right?
-Legacy
1 to 500, I list EVERY NUMBER....So I win by default now right?
-Legacy
259, 46
DJLegacy2k1
New member
I ALREADY GUESS ALL 50 NUMBERS PEOPLE, you can stop guessing now!
-Legacy
-Legacy
Fuck when is this thread going to end? When someone guesses correct, or when it hits 100 pages? Wtf?
SouthernLord said:
lol...
DJLegacy2k1
New member
DUDE I GUESS RIGHT!...
I GUESS EVERY SINGLE POSSIBILITY!
WHAT ARE YOU TALKING ABOUT?! hahaha
-Legacy
I GUESS EVERY SINGLE POSSIBILITY!
WHAT ARE YOU TALKING ABOUT?! hahaha
-Legacy
needtogetaas
New member
Lets wrap this up ross. Pick some one and give out that last bottle so I can close this thread. Thanks bro.
needtogetaas
New member
Ya I can't have this kicking around taking up space. Thanks for understanding.Ross said:
500
Ten Billion!
Tatyana
Elite Mentor
You used a lot of old Russian papers to say that your main ingredient worked.
Here is a more recent paper.
Usually, when there are positive results, the research papers EXPLODE, for example with things like creatine, nitric oxide, and the most recent promising supp, beta-alanine.
A more recent study
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2129166
Effects of Methoxyisoflavone, Ecdysterone, and Sulfo-Polysaccharide Supplementation on Training Adaptations in Resistance-Trained Males
Colin D Wilborn,1 Lemuel W Taylor,2 Bill I Campbell,3 Chad Kerksick,4 Chris J Rasmussen,3 Michael Greenwood,3 and Richard B Kreider3
1Human Performance Lab, University of Mary Hardin Baylor, Belton, TX
2Exercise Physiology Lab, University of West Florida, Pensacola, FL
3Exercise and Sport Nutrition Laboratory, Baylor University, Waco, TX
4Applied Biochemistry and Molecular Physiology Laboratory, University of Oklahoma, Norman, OK
Corresponding author.
Richard B Kreider: [email protected]
Received September 8, 2006; Accepted November 16, 2006.
Methoxyisoflavone (M), 20-hydroxyecdysone (E), and sulfo-polysaccharide (CSP3) have been marketed to athletes as dietary supplements that can increase strength and muscle mass during resistance-training. However, little is known about their potential ergogenic value. The purpose of this study was to determine whether these supplements affect training adaptations and/or markers of muscle anabolism/catabolism in resistance-trained athletes.
Methods
Forty-five resistance-trained males (20.5 ± 3 yrs; 179 ± 7 cm, 84 ± 16 kg, 17.3 ± 9% body fat) were matched according to FFM and randomly assigned to ingest in a double blind manner supplements containing either a placebo (P); 800 mg/day of M; 200 mg of E; or, 1,000 mg/day of CSP3 for 8-weeks during training. At 0, 4, and 8-weeks, subjects donated fasting blood samples and completed comprehensive muscular strength, muscular endurance, anaerobic capacity, and body composition analysis. Data were analyzed by repeated measures ANOVA.
Results
No significant differences (p > 0.05) were observed in training adaptations among groups in the variables FFM, percent body fat, bench press 1 RM, leg press 1 RM or sprint peak power. Anabolic/catabolic analysis revealed no significant differences among groups in active testosterone (AT), free testosterone (FT), cortisol, the AT to cortisol ratio, urea nitrogen, creatinine, the blood urea nitrogen to creatinine ratio. In addition, no significant differences were seen from pre to post supplementation and/or training in AT, FT, or cortisol.
Conclusion
Results indicate that M, E, and CSP3 supplementation do not affect body composition or training adaptations nor do they influence the anabolic/catabolic hormone status or general markers of catabolism in resistance-trained males.
They say it doesn't work, however it may have something to do with the dosing.
Also, you only have 75 mg of ecdysterone in your supp. You do say you need to take 5 tablets, twice daily, so 7500 mg/day, however it does seem for the dosing to be effective, it needs to be taken more frequently, and with protien.
It seems you need to take 100mg-200mg of 95% 20 beta ecdysterone every hour or 2, throughout the day, up to amounts of 750mg-1200mg each day to get the best results, depending upon your bodyweight.
The reason for taking 95% 20 beta ecdysterone every hour or 2 throughout the day is that once you have taken it orally it only has a short life in your system to do its work which is around 2 hours and because its job is to make muscle by protein synthesis it has to be taken with protein, thefore if you take protein every hour take 100mg 95% beta edysterone ( 1 tablet ) with it and if you take protein every 2 hours then double the amount of beta ecdysterone ( 2 tablets ).
A link on this site about ecdysterone
http://www.elitefitness.com/forum/bodybuilding-supplements/finally-truth-about-ecdysterone-689.html
Here is a more recent paper.
Usually, when there are positive results, the research papers EXPLODE, for example with things like creatine, nitric oxide, and the most recent promising supp, beta-alanine.
A more recent study
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2129166
Effects of Methoxyisoflavone, Ecdysterone, and Sulfo-Polysaccharide Supplementation on Training Adaptations in Resistance-Trained Males
Colin D Wilborn,1 Lemuel W Taylor,2 Bill I Campbell,3 Chad Kerksick,4 Chris J Rasmussen,3 Michael Greenwood,3 and Richard B Kreider3
1Human Performance Lab, University of Mary Hardin Baylor, Belton, TX
2Exercise Physiology Lab, University of West Florida, Pensacola, FL
3Exercise and Sport Nutrition Laboratory, Baylor University, Waco, TX
4Applied Biochemistry and Molecular Physiology Laboratory, University of Oklahoma, Norman, OK
Corresponding author.
Richard B Kreider: [email protected]
Received September 8, 2006; Accepted November 16, 2006.
Methoxyisoflavone (M), 20-hydroxyecdysone (E), and sulfo-polysaccharide (CSP3) have been marketed to athletes as dietary supplements that can increase strength and muscle mass during resistance-training. However, little is known about their potential ergogenic value. The purpose of this study was to determine whether these supplements affect training adaptations and/or markers of muscle anabolism/catabolism in resistance-trained athletes.
Methods
Forty-five resistance-trained males (20.5 ± 3 yrs; 179 ± 7 cm, 84 ± 16 kg, 17.3 ± 9% body fat) were matched according to FFM and randomly assigned to ingest in a double blind manner supplements containing either a placebo (P); 800 mg/day of M; 200 mg of E; or, 1,000 mg/day of CSP3 for 8-weeks during training. At 0, 4, and 8-weeks, subjects donated fasting blood samples and completed comprehensive muscular strength, muscular endurance, anaerobic capacity, and body composition analysis. Data were analyzed by repeated measures ANOVA.
Results
No significant differences (p > 0.05) were observed in training adaptations among groups in the variables FFM, percent body fat, bench press 1 RM, leg press 1 RM or sprint peak power. Anabolic/catabolic analysis revealed no significant differences among groups in active testosterone (AT), free testosterone (FT), cortisol, the AT to cortisol ratio, urea nitrogen, creatinine, the blood urea nitrogen to creatinine ratio. In addition, no significant differences were seen from pre to post supplementation and/or training in AT, FT, or cortisol.
Conclusion
Results indicate that M, E, and CSP3 supplementation do not affect body composition or training adaptations nor do they influence the anabolic/catabolic hormone status or general markers of catabolism in resistance-trained males.
They say it doesn't work, however it may have something to do with the dosing.
Also, you only have 75 mg of ecdysterone in your supp. You do say you need to take 5 tablets, twice daily, so 7500 mg/day, however it does seem for the dosing to be effective, it needs to be taken more frequently, and with protien.
It seems you need to take 100mg-200mg of 95% 20 beta ecdysterone every hour or 2, throughout the day, up to amounts of 750mg-1200mg each day to get the best results, depending upon your bodyweight.
The reason for taking 95% 20 beta ecdysterone every hour or 2 throughout the day is that once you have taken it orally it only has a short life in your system to do its work which is around 2 hours and because its job is to make muscle by protein synthesis it has to be taken with protein, thefore if you take protein every hour take 100mg 95% beta edysterone ( 1 tablet ) with it and if you take protein every 2 hours then double the amount of beta ecdysterone ( 2 tablets ).
A link on this site about ecdysterone
http://www.elitefitness.com/forum/bodybuilding-supplements/finally-truth-about-ecdysterone-689.html
Tatyana
Elite Mentor
Another exerpt from the first paper I posted the link to.
The full paper is there if anyone wants to read it.
I thought this bit was interesting.
Ecdysterones have also been recently purported to enhance training adaptations during resistance training. In support of this contention, research in animal models has suggested that ecdysterone supplementation can promote anabolic activity in skeletal muscle [5], as well as increase cell proliferation and growth, which can lead to an increase in muscle mass [6]. Russian scientists' have been evaluating the effects of ecdysterones for years. Oral administration of Leuza (herbal ecdysterone) in male albino mice caused a statistically significant increase in the time of running [19]. After 20 days of supplementation, there was a significant increase in work capacity.
The same researchers evaluated the effects of 20-day administration of ectisten-containing tincture of leuzea and leveton on humoral immunity of track and field runners for distances of 5,000 and 10,000 m. Intensive cyclic physical activity induced significant decrease of IgG and IgA in blood serum of the athletes. These researchers concluded that both supplements contributed to restoration of the lowered IgG and IgA, while the working capacity of the athletes grew by 10 to 15% [20]. Furthermore, Chermnykh et al [5] compared beta-ecdysterone with dianabol which is an extremely powerful anabolic steroid, suggesting both beta-ecdysterone and dianabol increased the size and strength of the muscles. These researchers concluded that ecdysterone had a greater anabolic action on the contractile proteins of the skeletal muscles than dianabol.
The most often cited scientific study on ecdysterone was published in Scientific Sports Bulletin by Simakin [21]. This study sought to determine the effect of ecdysterone on muscle tissue mass and fat mass, while testing for hormonal changes in the subjects. Seventy-eight highly trained male and female athletes served as subjects in one of three experimental groups: protein, protein and ecdysterone, and placebo. Those consuming just protein, showed only a slight increase in muscle mass for the 10 day period of time, while the placebo group experienced a slight reduction in lean muscle. The addition of ecdysterone in conjunction with protein intake resulted in a 6–7% increase in lean muscle tissue with nearly a 10% reduction in fat. Finally, Gadzhieva and colleagues [22] reported that 3-weeks of Ekdisten, leveton, and Prime Plus (combination of Ekdisten and pure protein) supplementation during training increased skinfold determined muscle mass, decreased fat mass, and increased total work during training. Additionally, Ekdisten and Prime Plus supplementation appeared to promote the greatest gains during training. These studies found that ecdysterone might increase work capacity, decrease fat mass, and increase lean muscle mass.
Results of the present study contrast these reports. In this regard, ecdysterone supplementation had no significant effects on body mass, body composition, strength, or markers of anabolic and catabolic status. Since most of the previous studies reporting positive effects of ecdysterones have been reported in obscure journals with limited details available to evaluate the experimental design and quality of the research, it is difficult to compare results. Nevertheless, present findings do not support the purported ergogenic benefit of ecdysterone supplementation in resistance-trained males.
The full paper is there if anyone wants to read it.
I thought this bit was interesting.
Ecdysterones have also been recently purported to enhance training adaptations during resistance training. In support of this contention, research in animal models has suggested that ecdysterone supplementation can promote anabolic activity in skeletal muscle [5], as well as increase cell proliferation and growth, which can lead to an increase in muscle mass [6]. Russian scientists' have been evaluating the effects of ecdysterones for years. Oral administration of Leuza (herbal ecdysterone) in male albino mice caused a statistically significant increase in the time of running [19]. After 20 days of supplementation, there was a significant increase in work capacity.
The same researchers evaluated the effects of 20-day administration of ectisten-containing tincture of leuzea and leveton on humoral immunity of track and field runners for distances of 5,000 and 10,000 m. Intensive cyclic physical activity induced significant decrease of IgG and IgA in blood serum of the athletes. These researchers concluded that both supplements contributed to restoration of the lowered IgG and IgA, while the working capacity of the athletes grew by 10 to 15% [20]. Furthermore, Chermnykh et al [5] compared beta-ecdysterone with dianabol which is an extremely powerful anabolic steroid, suggesting both beta-ecdysterone and dianabol increased the size and strength of the muscles. These researchers concluded that ecdysterone had a greater anabolic action on the contractile proteins of the skeletal muscles than dianabol.
The most often cited scientific study on ecdysterone was published in Scientific Sports Bulletin by Simakin [21]. This study sought to determine the effect of ecdysterone on muscle tissue mass and fat mass, while testing for hormonal changes in the subjects. Seventy-eight highly trained male and female athletes served as subjects in one of three experimental groups: protein, protein and ecdysterone, and placebo. Those consuming just protein, showed only a slight increase in muscle mass for the 10 day period of time, while the placebo group experienced a slight reduction in lean muscle. The addition of ecdysterone in conjunction with protein intake resulted in a 6–7% increase in lean muscle tissue with nearly a 10% reduction in fat. Finally, Gadzhieva and colleagues [22] reported that 3-weeks of Ekdisten, leveton, and Prime Plus (combination of Ekdisten and pure protein) supplementation during training increased skinfold determined muscle mass, decreased fat mass, and increased total work during training. Additionally, Ekdisten and Prime Plus supplementation appeared to promote the greatest gains during training. These studies found that ecdysterone might increase work capacity, decrease fat mass, and increase lean muscle mass.
Results of the present study contrast these reports. In this regard, ecdysterone supplementation had no significant effects on body mass, body composition, strength, or markers of anabolic and catabolic status. Since most of the previous studies reporting positive effects of ecdysterones have been reported in obscure journals with limited details available to evaluate the experimental design and quality of the research, it is difficult to compare results. Nevertheless, present findings do not support the purported ergogenic benefit of ecdysterone supplementation in resistance-trained males.
Tatyana
Elite Mentor
Home | Contact | Search | Become a Member
Citrulline malate: Does it work?
Citrulline malate is being promoted as a way to boost endurance and give you more energy to train harder and recover faster.
Citrulline malate
Citrulline malate is a mixture of citrulline, which is involved in the urea cycle, and malate, a tricarboxylic acid cycle intermediate. It is usually prescribed as an antiasthenic treatment.
Previous studies in humans and rats show that citrulline malate improves muscle performance of subjects suffering from asthenia (a condition which describes the loss or lack of body strength).
There are very few studies on citrulline malate. Most of them involve rats. In one such study, resistance to fatigue improved after treatment with citrulline malate [2].
In one of the few human studies, researchers examined the effects of supplementation with six grams of citrulline malate daily for 15 days [1].
The results show that citrulline malate led to a significant reduction in the sensation of fatigue, a 34% increase in the rate of oxidative ATP production during exercise, and a 20% increase in the rate of phosphocreatine recovery after exercise. This indicates a larger contribution of oxidative ATP synthesis to energy production.
These results are interesting, but the study does have various weaknesses.
Firstly, the study was not double-blinded with a placebo and control group.
Studies involving food supplements, sports drinks, energy bars and other performance aids usually follow this format. A placebo is a "fake" supplement used to reduce the influence of faith and belief in a treatment on the results of a study.
Double-blinded means that neither the researcher nor the test subject knows which supplement or drug they are getting. If either person knows, it can have a big influence on the results.
"The absence of a placebo control group meant that we could not eliminate a placebo effect," say the researchers, "which would have to be addressed by a double blinded placebo versus control trial."
The exercise test used to measure performance involved finger flexions performed at 1.5 second intervals with a six-kilogram (12 pounds) weight. We don't know if the same improvements in performance would be seen during exercises such as the squat or bench press.
What's more, the subjects were 18 inactive men who complained of fatigue. They weren't regular exercisers.
In other words, the subjects were tired, inactive men who performed finger exercises before and after supplementation. Because of this, the results don't neccesarily apply to active people wanting to lose fat and build muscle.
The bottom line is that citrulline malate does have the potential to enhance performance, but more relevant human research is needed before we can conclude that it enhances strength, muscle growth or fat loss.
Reference
1. Bendahan, D., Mattei, J.P., Ghattas, B., Confort-Gouny, S., Le Guern, M.E., & Cozzone, P.J. (2002). Citrulline/malate promotes aerobic energy production in human exercising muscle. British Journal of Sports Medicine, 36, 282-289
2. Goubel F, Vanhoutte C, Allaf O, Verleye M, Gillardin JM. (1997). Citrulline malate limits increase in muscle fatigue induced by bacterial endotoxins. Canadian Journal of Physiology and Pharmacology, 75, 205-207
Citrulline malate: Does it work?
Citrulline malate is being promoted as a way to boost endurance and give you more energy to train harder and recover faster.
Citrulline malate
Citrulline malate is a mixture of citrulline, which is involved in the urea cycle, and malate, a tricarboxylic acid cycle intermediate. It is usually prescribed as an antiasthenic treatment.
Previous studies in humans and rats show that citrulline malate improves muscle performance of subjects suffering from asthenia (a condition which describes the loss or lack of body strength).
There are very few studies on citrulline malate. Most of them involve rats. In one such study, resistance to fatigue improved after treatment with citrulline malate [2].
In one of the few human studies, researchers examined the effects of supplementation with six grams of citrulline malate daily for 15 days [1].
The results show that citrulline malate led to a significant reduction in the sensation of fatigue, a 34% increase in the rate of oxidative ATP production during exercise, and a 20% increase in the rate of phosphocreatine recovery after exercise. This indicates a larger contribution of oxidative ATP synthesis to energy production.
These results are interesting, but the study does have various weaknesses.
Firstly, the study was not double-blinded with a placebo and control group.
Studies involving food supplements, sports drinks, energy bars and other performance aids usually follow this format. A placebo is a "fake" supplement used to reduce the influence of faith and belief in a treatment on the results of a study.
Double-blinded means that neither the researcher nor the test subject knows which supplement or drug they are getting. If either person knows, it can have a big influence on the results.
"The absence of a placebo control group meant that we could not eliminate a placebo effect," say the researchers, "which would have to be addressed by a double blinded placebo versus control trial."
The exercise test used to measure performance involved finger flexions performed at 1.5 second intervals with a six-kilogram (12 pounds) weight. We don't know if the same improvements in performance would be seen during exercises such as the squat or bench press.
What's more, the subjects were 18 inactive men who complained of fatigue. They weren't regular exercisers.
In other words, the subjects were tired, inactive men who performed finger exercises before and after supplementation. Because of this, the results don't neccesarily apply to active people wanting to lose fat and build muscle.
The bottom line is that citrulline malate does have the potential to enhance performance, but more relevant human research is needed before we can conclude that it enhances strength, muscle growth or fat loss.
Reference
1. Bendahan, D., Mattei, J.P., Ghattas, B., Confort-Gouny, S., Le Guern, M.E., & Cozzone, P.J. (2002). Citrulline/malate promotes aerobic energy production in human exercising muscle. British Journal of Sports Medicine, 36, 282-289
2. Goubel F, Vanhoutte C, Allaf O, Verleye M, Gillardin JM. (1997). Citrulline malate limits increase in muscle fatigue induced by bacterial endotoxins. Canadian Journal of Physiology and Pharmacology, 75, 205-207
Tatyana
Elite Mentor
J Nutr. 2007 Jun;137(6):1621S-5S. Links
Citrulline: a new player in the control of nitrogen homeostasis.
Moinard C,
Cynober L.
Laboratoire de Biologie de la Nutrition, EA 2498, Faculte de Pharmacie, Universite Paris Descartes, France and 5Laboratoire Biochimie, Hotel-Dieu, AP-HP, Paris 75004, France.
Citrulline (CIT) is an amino acid that is not involved in protein synthesis but that is tightly linked to arginine (ARG) metabolism. CIT displays a very specific metabolism: In the 1980s, Windmuller demonstrated that the small intestine releases CIT, which is mainly taken up by the kidney and metabolized into ARG. Because CIT is not taken up by the liver, this ARG-CIT-ARG cycle can be seen as a means of protecting dietary ARG from liver degradation and of sustaining protein homeostasis. These observations have led to the concept that plasma CIT concentration would be a good marker of intestinal failure in short bowel syndrome. Hence, in massive intestinal resection, citrullinemia is greatly reduced, and this is proportional to the severity of the intestinal disease. This concept was then extended to other situations in which the intestinal function is compromised. The data strongly suggest that CIT may be a conditionally essential amino acid in situations where the intestinal function is compromised. Recent data support this idea. Thus, CIT supplementation is able to restore nitrogen balance, generate large amounts of ARG in rats with short bowel syndrome, and increase muscle protein content (+20%) as well as muscle protein synthesis (+90%) in elderly malnourished rats. Finally, recent data indicate that CIT per se could be able to stimulate muscle protein synthesis. Hence, CIT could play a pivotal role in maintaining protein homeostasis, and the determination of the underlying mechanisms involved in its action should be important for the development of new nutritional strategies in malnourished patients with compromised intestinal functions.
PMID: 17513438 [PubMed - in process]
Citrulline: a new player in the control of nitrogen homeostasis.
Moinard C,
Cynober L.
Laboratoire de Biologie de la Nutrition, EA 2498, Faculte de Pharmacie, Universite Paris Descartes, France and 5Laboratoire Biochimie, Hotel-Dieu, AP-HP, Paris 75004, France.
Citrulline (CIT) is an amino acid that is not involved in protein synthesis but that is tightly linked to arginine (ARG) metabolism. CIT displays a very specific metabolism: In the 1980s, Windmuller demonstrated that the small intestine releases CIT, which is mainly taken up by the kidney and metabolized into ARG. Because CIT is not taken up by the liver, this ARG-CIT-ARG cycle can be seen as a means of protecting dietary ARG from liver degradation and of sustaining protein homeostasis. These observations have led to the concept that plasma CIT concentration would be a good marker of intestinal failure in short bowel syndrome. Hence, in massive intestinal resection, citrullinemia is greatly reduced, and this is proportional to the severity of the intestinal disease. This concept was then extended to other situations in which the intestinal function is compromised. The data strongly suggest that CIT may be a conditionally essential amino acid in situations where the intestinal function is compromised. Recent data support this idea. Thus, CIT supplementation is able to restore nitrogen balance, generate large amounts of ARG in rats with short bowel syndrome, and increase muscle protein content (+20%) as well as muscle protein synthesis (+90%) in elderly malnourished rats. Finally, recent data indicate that CIT per se could be able to stimulate muscle protein synthesis. Hence, CIT could play a pivotal role in maintaining protein homeostasis, and the determination of the underlying mechanisms involved in its action should be important for the development of new nutritional strategies in malnourished patients with compromised intestinal functions.
PMID: 17513438 [PubMed - in process]
B
Big_BK
Guest
tat owns all.
Big Rick Rock
istrator
Tatyana is putting a lot of effort into discrediting Ross... Disturbing.
Tatyana
Elite Mentor
Big Rick Rock said:
Not really that much effort.
I read a lot, and I have a funny memory that I remember odd bits about certain supps and compounds.
Also, it's part of my job to critically evaluate scientific papers.
So when someone is claiming that a supp is the newest and greatest thing, but the papers are close to thirty years old (and Russian obscure papers), little warning bells go off.
Big Rick Rock
istrator
Tatyana said:
The steroid I took this morning was designed over 60 years ago ! !
Tatyana
Elite Mentor
Big Rick Rock said:
So was penicillin.
That wasn't the issue I was addressing.
There is old research that is valid and will never be repeated, for example, there is a great study from the 1920s or 30s where they weighed rabbits and all their organs and glands, or when they took blood samples from people in the 1960s every hour on the hour to determine fluctuations in various analytes.
I am also right now trying to get my hands on a 1973 paper about a method for precipitating immunoglobulins, the first time it was described.
With regards to the last paper, this is the rub, it was the FIRST time it was described, the method is solid, and it is used ALL the time, just with tweaks for various analytes.
Some older research papers are not of any clinical or research value, and I assert the papers Ross has been citing are in that vein.
I have over 10 years of doing this sort of scientific literacy, and three science degrees.
I do have an idea of what I am talking about.
Big Rick Rock
istrator
Tatyana said:
Tatyana... Forgetting about these research papers for a minute (many of which can be wrong. A lot actually)
You have been around this industry for a while... What do you think about Citrulline Malate in Bodybuilding formulas? I mean ALL formulas. Because Ross is not the only one putting the stuff in a capsule... You visit other forums and read people's reviews on products. What have other bodybuilders been saying about it???
I know Mavafanculo thinks is a great product. He suggested it to me recently for something I was researching...
What do you think about the actual use of it?
didnt EAS market some ecdysterone way back when?
juiceddreadlocks said:
The ONLY Ecdysterone CLINICALLY PROVEN TO BE ANABOLIC is the *PATENTED "EcdyPure" 99% PURE Ecdysterone derived from Rhaponticum Carthamoides!
The Chinese garbage in that EAS product is NOT the same as our PATENTED MATERIAL!
Ecdysterone has been tested for its effects on work capacity, immune function, lean body mass and fat loss, among other variables in a number of scientific studies. The vast majority of research indicates an increase in test subjects' lean mass. Results were further improved when ecdysterone was consumed with protein.
Increase Protein Synthesis and Invoke Positive Nitrogen Balance:
Studies conducted in the Soviet Union in 1988 showed ecdysterone helps "increase hepatic protein synthesis and subsequently promote positive nitrogen balance!" How does this lead to more muscle mass? Simply: "the more nitrogen your body maintains and the greater rate of protein synthesis, the more mass, period." How, exactly, does ecdysterone do this?
V. Smetanin, researcher of the Smolenk State Medical Institute in Russia speculates that ecdysterone decreases urea concentration in the body and increases hemoglobin levels by increasing a process called erythropoiesis. Erythropoiesis is the development of mature red blood cells. This leads to a stimulation of the anabolic process in protein metabolism, which in turn leads to a positive nitrogen balance in the body.
Increase Lean Muscle Mass While Reducing Body Fat:
The most often quoted ecdysterone scientific study was published in Scientific Sports Bulletin by S. Simakin in 1988. The objective of Simakin's famous study was to determine the effect of ecdysterone on muscle tissue mass and fat mass, while testing for hormonal changes in the subjects.
For the study, three control factors were used: a placebo, protein, and ecdysterone with protein. The results were significantly in favor of the third factor. Of the 78 highly trained male and female athletes who consumed just protein, they showed only a slight increase in muscle mass for the 10 day period of time.
Those who used a placebo lost a slight amount of lean muscle, while those who used protein plus ecdysterone showed a 6-7% increase in lean muscle tissue with nearly a 10% reduction in fat! Let me say that again: A 10% reduction in fat and a 7% increase in lean muscle tissue in just 10 days! Safety testing was conducted during the same time period which showed no difference in hormonal balance. Wow, if ecdysterone plus protein can do this for highly trained athletes, just think what it can do for the average person!
Increase Stamina, Endurance, And Energy:
Ecdysterone was tested in another study performed in 1986 by B.Ya Smetanin. For this research, 117 highly trained speed skaters between the ages of 18 and 28 were tested for work capacity, body weight, lung capacity and VO2 max. The results speak for themselves: all of the said parameters increased as well as an increase in the O2 pulse max and an increase in the exhalation of CO2.
Basically, they received more oxygen to their cells! This equates to decreasing recovery time, maximizing performance, permitting optimal muscle anabolism and maximum fat reduction. It also means the athletes using ecdysterone compared to those on a placebo experienced increased stamina, endurance and energy.
That's not all! A study conducted using 112 athletes performed by B.G. Fadeev in Russia showed some very impressive overall results. However, by this time, the results should come as no surprise. 89% of those who supplemented with ecdysterone versus a placebo reported less fatigue, greater performance, more motivation, greater speed, and improved strength. How long did it take before these athletes reported these effects? Months? Weeks? No, five days. To make matters even better, no adverse side effects were reported.
Ecdysterone compared to methandrostenolone (D-Bol):
The action of methandrostenolone and ecdysterone on the physical endurance of animals and on protein metabolism in the skeletal muscles.
Author:
Chermnykh NS ; Shimanovski¨ i NL ; Shutko GV ; Syrov VN
Farmakol Toksikol, 51(6):57-60 1988 Nov-Dec
Abstract:
The results of the comparative study on the myotropic activity of methandrostenolone and ecdysterone and their effects on physical endurance of animals suggested that ecdysterone possessing a wider spectrum of the anabolic action on the contractile proteins of the skeletal muscles exerts a more pronounced influence on physical endurance of animals without their preliminary training.
This study shows anabolic effects with no androgenic effects as compared to D-bol:
Anabolic activity of phytoecdysone-ecdysterone isolated from Rhaponticum carthamoides.
Author:
Syrov VN ; Kurmukov AG
Farmakol Toksikol, 39(6):690-3 1976 Nov-Dec
Abstract:
Introduction of phytiexdizone-exdisterone (0.5 mg/100 g) to rats for 7 days is shown to be attended by an accelerated body weight gain and also by a rising weight of the liver, heart, kidneys and musculus tibialis anterior. In these organs the total amount of protein increases. All of the above-stated changes are more marked when the substance is given to growing rats (70--80 g). In experiments on castrated sexually immature rats the androgenic action of exdisterone, unlike that of methandrostenolone, is not demonstrable.
Positive insulin response:
The effect of nerobol and ecdysterone on insulin-dependent processes linked normally and in insulin resistance
Author:
Kosovski¨ i MI ; Syrov VN ; Mirakhmedov MM ; Katkova SP ; Khushbaktova ZA
Probl Endokrinol (Mosk), 35(5):77-81 1989 Sep-Oct
Abstract:
The effect of substances with anabolic activity (metandienone and ecdysterone phytoecdysteroid) on the manifestation of insulin effects was studied on a model of insulin resistance in rats induced by injections of hydrocortisone or by insulin insufficiency caused by alloxan. The sensitivity of the body to i. v. infusion of insulin and the reactivity of isolated fatty tissue to the hormone were increased after administration of these substances to test animals. The above effects of steroids were determined by nonspecific synthesis of total proteins in cells rather than by an increase in insulin secretion.
Also a very very strong adaptogen and antioxidant:
Antioxidant effect of 20-hydroxyecdysone in a model system
Kuz'menko AI - Ukr Biokhim Zh - 1999 May-Jun; 71(3): 35-8
Original Title:
Izuchenie antiokislitel'nogo effekta 20-gidroksiekdizona v model'noi sisteme.
Abstract:
Changes in the level of lipid free-radical oxidation in mitochondrial fraction at the presence of 20-hydroxyecdysone in 1, 2, 4, 6, 8 microM concentration with the help of a chemiluminescence (ChL) method were investigated in vitro. Statistically authentic reduction of ChL kinetic parameters--I(s) and tg alpha, at 20-hydroxyecdysone presence in concentration of 2 microM was found. 20-hydroxyecdysone administration in concentration 4 microM and more leads to the statistically authentic change of all four ChL parameters. The antioxidizing effect of 20-hydroxyecdysone was compared with action of such antioxidant as a hydroquinone. The higher activity of 20-hydroxyecdysone as an antioxidant in comparison with the hydroquinone was shown. For changes of all four measured kinetic parameters of ChL, concentration of the hydroquinone as much 2-fold than for 20-hydroxyecdysone is necessary. On the basis of our researches in the model system a conclusion was made that 20-hydroxyecdysone has an antioxidizing action on lipid free radical oxidation in mitochondrial fraction in dependents on concentration. 20-Hydroxyecdysone has antioxidizing properties directly, in these conditions in vitro, when its metabolites formation does not occur yet.
Anabolic activity of Ecdysterone in Quail
Insect hormones in vertebrates: anabolic effects of 20-hydroxyecdysone in Japanese quail
Slama K - Experientia - 1996 Jul 15; 52(7): 702-6
Authors:
Slama K; Koudela K; Tenora J; Mathova A
Abstract:
Ecdysteroids are hormones controlling cell proliferation, growth and the developmental cycles of insects and other invertebrates. They are occasionally present in various unrelated plants for no apparent reason; no phytohormonal function has yet been identified. In certain cases, ecdysteroids are accumulated to high levels in leaves, roots or seeds. Some ecdysteroid-containing plants have been known as medicinal plants for centuries. One of them, Leuzea carthamoides Iljin (Asteraceae), growing in Central Asia, contains 0.4% ecdysteroid in dry roots and 2% in seeds. A pharmacological preparation from this plant, "Ecdisten', is already available as a commercial preparation for its anabolic, tonic and other effects, for medical use (review). It remained problematic, however, whether ecdysteroids were truly responsible for these effects, because Leuzea contains a number of other biologically active compounds in addition to ecdysteroids. We extracted and purified ecdysteroids from the seeds of Leuzea. With 6 g of 96% 20-hydroxyecdysone (20E), we made a large-scale feeding assay with Japanese quail to find out whether ecdysteroid alone could duplicate the anabolic effects of the seeds. We found that the 96% ecdysteroid increased the mass of the developing quails in a dose-dependent manner, with the rate of increase proportional to the ecdysteroid content in the seeds; there was a 115% increase in living mass with 100 mg kg-1 of pure 20E compared with 109.5% increase with 100-180 mg kg-1 20E equivalents in the seeds. We conclude that the plethora of growth-promoting, vitamin-like effects induced in vertebrates by Leuzea is mediated by ecdysteroids.
Study demonstrating the Anabolic effect of 6-Keto Diosgenin
[Experimental study of the anabolic activity of 6-ketoderivatives of certain natural sapogenins][Article in Russian]
Syrov VN, Kurmukov AG.
It is shown that 6-ketoderivatives of natural sapogenins, viz. agigenin, diosgenin and alliogenin, display the anabolic activity and do not manifest any androgenic properties. The compoud IV/(25 R)-5alpha-spirostan-2alpha, 3beta, 5alpha-triol-6-OH/produces an accelerated gain of weight in rats, and also an increase in the weight of the liver, heart, kidneys, musculus tibiliasis anterior and augments the total amount of protein therein. All of the above-mentioned changes become more pronounced with the study substance introduced to young animals. Castration of sexually immature rats greatly mitigates the anabolic effect of the compound IV.
PMID: 1028596 [PubMed - indexed for MEDLINE]
8and20 said:
really? what makes u say that?
I'd like to know why it contains diosgenin.
Mavafanculo
New member
from personal use, and based on my reading/research before deciding to try it, Citrulline Malates a winner. I dont have any references off hand, but my readings at the time convinced me that the claims for it were reasonably well supported.
IE, that it increases NO levels better than arginine and is synergistic with it (for better pump, vasodialation and resultant nutrient delivery/growth), and that it helps clear lactic acid (for better endurance and squezing out a few more reps).
IE, that it increases NO levels better than arginine and is synergistic with it (for better pump, vasodialation and resultant nutrient delivery/growth), and that it helps clear lactic acid (for better endurance and squezing out a few more reps).
Last edited:
Nelson Montana said:
It doesn't, it contains 6-Keto Diosgenin(25R-Spirost-4-ene-3,6-diol)
Dr. Syrov and Dr. A.J. Kurmukov published a study entitled, "The Experimental Study of the Anabolic Activities of the 6-Keto Derivatives of Some Natural Sapogenins", in which they analyzed the various sterol compounds from these plant sources. They found several adaptogens in addition to the beta-ecdysterone, including agigenin, disogenin and alliogenin, all of which displayed further anabolic activity, but none of which displayed androgenic properties. This basically means that this group of sapogenins do not have any influence in elevating or decreasing the testosterone levels of the person taking them. This is precisely what the Russians wanted, since they were having several of the world class athletes fail urine tests in international competition because they were taking synthetic steroids. What Dr. Syrov and his colleagues further showed was a dramatic improvement in liver, kidney, heart and muscular activity, and a dramatic increase in the total amount of protein found within these organs. In other words, there is an increase in protein synthesis in all of the major organs of the body, including muscular tissue, with no effect on the hormonal activity of the body. This is remarkable and exciting because it thus poses no threat to the individual in terms of toxicity and/or the capacity to increase existing cancers. As a matter of fact, several South American physicians have used this compound extensively to battle cancer and even a very difficult disease known as Chronic Fatigue Syndrome, which is normally considered to be a viral infection.
Study demonstrating the Anabolic effect of 6-Keto Diosgenin
[Experimental study of the anabolic activity of 6-ketoderivatives of certain natural sapogenins][Article in Russian]
Syrov VN, Kurmukov AG.
It is shown that 6-ketoderivatives of natural sapogenins, viz. agigenin, diosgenin and alliogenin, display the anabolic activity and do not manifest any androgenic properties. The compoud IV/(25 R)-5alpha-spirostan-2alpha, 3beta, 5alpha-triol-6-OH/produces an accelerated gain of weight in rats, and also an increase in the weight of the liver, heart, kidneys, musculus tibiliasis anterior and augments the total amount of protein therein. All of the above-mentioned changes become more pronounced with the study substance introduced to young animals. Castration of sexually immature rats greatly mitigates the anabolic effect of the compound IV.
PMID: 1028596 [PubMed - indexed for MEDLINE]
Tatyana
Elite Mentor
Big Rick Rock said:
Yes, I agree some research papers have issues with them. Some of them are published with conflicting interests, and usually there is an purely economic reason behind them.
Citrulline malate does look promising.
It is in a similar boat to glutamine right now, it has demonstrated benefits in patients, however, the results in trained athletes is not entirely clear.
However the 'chaste berry' herb, ecy...... well, it looks like a load of bollux.
Also if you will note, I also pointed out a possible issue in the paper I posted, that they may not have a large enough dose of the the herb.
Ross said:WINNER!!
Please PM me your shipping details.
He bro how exactly was this supposed to work? I guessed that number (420) as the seventh post in this thread. He guessed that number (420) as the 56th post. Is it first come first serve or what????
needtogetaas
New member
Tatyana ross's best marketing tool right now. Free press,free thread bumps keep it coming!!!!!!!!!
Btw ross I know I will be trying our products soon right?
Btw ross I know I will be trying our products soon right?
needtogetaas
New member
If I get the shits I am kicking your ass. lol. I know how things get hyped though so O am not worried about it. I will be using it when I got back on my hrt doses.Ross said:Of course my man, the STACK.
Mavafanculo
New member
SouthernLord said:
If digger sees your avatar before you change it, you'll get a chance to guess another number. how many days your timeout will be for lol.
please change the nanivatar
Mavafanculo said:
lol...
Similar threads
