DMT causes intense visual hallucinations and other psychedelic phenomena. It has been mostly encountered in the technologically developed world as a pink (cool) crystalline powder, which was smoked or injected. This caused nearly instant, brief, and intense trips. Peaks occur immediately and last around 10 minutes, with another 30 or so minutes of mild effects.
5-Me-DMT is a close relative of DMT. 5-Me-DMT is reported to be about 4 times as potent as DMT and is often regarded as preferable to DMT. 5-Me-DMT has most of the psychedelic qualities as DMT but does not cause visual hallucinations. It follows the same time course.
Bufotenine (5-OH-DMT) is another DMT relative. This compound is vaguely referred to as "noxious" by Jonathan Ott. Apparently 10mg of pure 5-OH-DMT injected is enough to cause "dramatic circulatory crises." There appears to be debate over the psychedelic qualities of bufotenine. However, McLeod & Sitaram, Shulgin, and Fabins & Hawkings all report the presence of psychotomimetic effects. Bufotenine causes anxiety, circulatory distress, skin flushing, and percieved color distortions. Injected doses of 16 mg (over 3 min. IV drip) have been reported. At this dose, the symptoms of mild skin flushing to extreme purple cast appear. Subjects also report a great deal of psychological distress and fear at this dose. Doses of 8 mg produce mild skin flushing and increased anxiety. Doses of 2-4 mg of bufotenine do not produce hallucinogenic effects. The above discussed negative side effects at 16 mg last for approximately 10 minutes. Other side effects reported are sweating, nausea, yellowed vision, and perception of colored spots. So it appears that bufotenine is a nasty drug to be avoided, Not only does it tend to induce panic, it also appears to have the potential for a fatal overdose, although no case studies to this effect have been found for humans.
Other DMT relatives exist, but are not of great importance here. Some are, however, psychoactive.
DMT in the past has only been used by smoking or injecting. Oral use was completely ineffective. It turns out that ancient tribal cultures solved that problem aeons ago, and have been dosing up the whole time. Now THAT'S technology. By combining plants that contained MAOIs (monoamine oxidase inhibitors) and other plants containing DMT, the DMT would become active orally. MAOIs block the destruction of DMT in the digestive track and in the brain. So, with MAOIs, DMT can be eaten and also becomes more potent. MAOIs also increase the potency of smoked DMT. The effect of the orally administered DMT with MOAI lengthens in time and decreases in intensity. Typical plateau period is 10-40 minutes, after a hour delay with low buzz for an hour after the plateau. Great for people who don't like the time investment of most psychedelics.
MAOIs are reported to work for psilocybin ('shrooms) and mescaline. Subjective reports are that MAOIs double their potency. I hypothesize that it will also potentiate lysergic acid (woodrose and morning-glories). The effect of MAOIs on LSD appears debated in the literature. Some report no effect, others report significant potentiation. Some have very enthusiastically insisted that MAOIs double or triple the potency of LSD.
The ancient solution mentioned above is the ayahuasca potion. This potion has been produced, in one form and name or another, throughout Central America and South America for quite some time. The most commonly referred to potion is made by combining ayahuasca, a jungle vine, and yopo, leaves from a small bush. The ayahuasca provides the MAOIs and the yopo provides DMT. Occasional, mescaline bearing cacti are added. The potion was usually used ceremonial for healing, divining, and teaching. Often there are reports of blue glows and jaguars, a holy animal in many endogenous South American cultures. I have been told that McKenna reports that eskimos given an ayahuasca type potion reported seeing large cats, which, of course, are not arctic animals. I however, have found (from admittedly little reading) McKenna's work to be questionable and less than scientific. However, his reports often do parallel others.
MAOIs are a class of drugs that all do the same thing: prevent the destruction of monoamines (like DMT). One MAOI is harmaline. Harmaline is easily obtained. Syrian rue is an excellent source. Three grams of seed, extracted with the DMT or eaten alone should suffice. Harmaline containing plants can also be smoked for a more rapid onset. Doses over three grams do not add more potency. Caution should be used with MAOIs. Large doses are hallucinogenic in and of themselves. Large doses are unpleasant and sometimes fatal.
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