mountain muscle
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swatdoc said:You quoted my message as I was editing it to add some more info.
When you're dehydrated, your renal juxtoglomerular cells produce renin. Renin stimulates angiotensin II production through a complex pathway (by way of angiotensin I), which is dependent on angiotensin-converting enzyme (ACE). This is how ACE-inhibitors work. They prevent the production of angiotensin II.
Angiotensin II had effects on heart, lungs, and kidneys. It causes the kidneys to produce aldosterone, which causes sodium retention (this would cause water retention). Angiotensin II also has a direct effect on sodium reabsorption in the renal proximal tubules. ACE-I's ultimately block sodium retention by decreased production of aldosterone by inhibiting production of angiotensin II.
So in effect, ACE-I's will block sodium reabsorption, which might lead to increased urination and predispose you to dehydration. When you're dehydrated, you won't be able to mount as great a response to dehydration as someone who is not on ACE-I's.
It's been a while since I learned all this crap (ahem, "stuff") in medical school, so some of the finer details of the above may have been lost by my post-med school dementia. The basic concept applies though.
I appreciate it Doc. I read earlier today that it increases natriuresis and was wondering if that might be the culprit.
they didn't teach this stuff in roughneck school lol.