Diesel3d said:
i don't see how this would be considered hype. ALA is one of the biggest things on this board, so it's very important people know about this. for the better of all the people using ALA, the word needs to get out to maxamize our progress and saftey . For gods sake 99.9% of us depend on ALA to detox our liver.
The facts of r-ala and s-ala are very real, you can see here http://boards.elitefitness.com/forum/showthread.php?s=&threadid=151547 ....
As I said above, hype is hype, I'm not assigning a negative connotation to it. Are you?
I'm fully aware of the facts about R(+)-lipoic acid, S(-)-lipoic acid and the racemic mixes of the two. I was posting articles about them before AF even came out with the product. Decadense was actually the one that brought R and S properties to my attention.
There's no doubt that pure R ALA is technically a better product than racemic mixes. However, there's no doubt that racemic mixes have been used effectively for quite some time by athletes, diabetics and life-extensionists.
If you're using it as an antioxidant, than R vs racemic doesn't really matter as both R and S have effective antioxidant properties (although R is admittedly better). And I would surmise that the insulin sensitivity issue in this case would be nil as small quantities are consumed for this purpose and the R and S components would effectively cancel one another out (with R gaining a slight edge).
Where it
may matter is for those using it to induce ketosis. In racemic mixes, the S does have some negative insulin sensitivity impact (and other issues), but the R component is able to overtake that. By definition, half of racemic mixtures are R-type. Traditional ALA manufacturing produces a R/S racemate mix of 50/50. Assuming you get a product that isn't damaged (as Ulter aluded to) than your mix will be 50/50. It's not separated because it's very expensive to separate. (Pure R is manufactured with a different process that doesn't yield the S racemate.)
As a result, you have to proportionally ingest more R type in a racemic mixture than you would in a pure R-type formulation. (we don't know what this ratio is yet though, although 3:1 is what is being 'hyped').
In simple terms, we need to know that for a given body of subjects it took 3 grams (example) of racemic to maintain ketosis (as tested by ketostix), and under the same conditions, it only took one gram (example) of R to maintain the same state.
But, in the real world, most guys that are using it to induce ketosis are going in only several week bursts and then returning to homeostasis. So, once you are at or over the ratio threshold (ex. 3:1) in short applications, does the advantage of pure R really matter except in only the most technical sense? There's data that suggests long-term ingestion of S is not great for you, but in a short application I don't really know.
So, we have to take some time and see if it lives up to the hype.