Ypur backne is from your body responing to test you never had. Do Accutane now and you'll never get it again, (I was there). The doc will likely prescribe high does (80mg/ed) which is hell on ya, so get the script and just take a tiny dose for a longer time. I had labs monthly and all was fine with the route. As for test, keep your total test at the top of the range and you won't need to cycle for a long time. Just make sure your doc checks all hormones, E, etc. Your dose actually sounds quite high for HRT. I'm 210lbs and keep at the top of range w/ 100mg/wk.