Carth, as you know i've quite sensitive to estrogen sides, but i have taken letro effectively at 2.5mg every 3rd day, and also taken it effectively at .625mg/day
As for your heavy test stack with high letro, YES, it works great. The only time i ever ran 1500mg test/week i ran letro at 2.5mg EOD and i stayed dry as hell. I had started the letro at 2.5mg/day and halfway through dropped it to 2.5mg EOD and stayed just as dry.......and remember, i seem to convert test to estrogen VERY easily
Thing about letro is that its effects can be noticed so very quickly. Say you are taking 1.25mg EOD and you think you need more you can up the dosage and see effects almost immediately. Thats what I like about it
So to answer your question i think you could easily run that amount of test with 1.25mg letro ED or possibly even less