Do AI's Lose effectiveness??

[warrio2345]

Dont breath to much into the question just more for curisoity. Pros as most understand it, stay on gear year round. They use AI's (adex,letro,aroma) and stuff for 10 years at a time when you consider most started very young...
My question is do AI's over time lose potencty on your body or simply just stop working for you at some point or will AIs lose maybe lose a little efficeiency over the course of the years but negligable in terms of it actully effecting you in the sence that the AI no longer works...???

 

[warrio2345]

So, is the AI loseing effectiveness just a myth or what...? Especailly with something like Aromasin...I mean aromasin doesnt block estrogen so your body never stp producing estro while on aromasin like it does wit adex or letro, it merely make the aromatose enzyme impossible to function, so I would think b/c it deactivates the enzyme and does not merely block production that Aromasin at least could be used long term with no problem it losing effectivenss..

 

[Varga]

As far as I know they dont lose effectivness I've been taking them for years and they still work.
Aromasin doesnt work like that as far I know ...It does lower the production of the enzyme responsible for estrogen manufacturing so estrogen is never produced without the enzyme. It sounds somewhat like what nolvadex would do by blocking receptors from uptaking estrogen from your description.

 

[Nelson Montana]

No. If the demand for more doesn't go up a stable dose is all that's required.

 

[warrio2345]

Just talked to another guyand he said, that he doesnt know why the Ais would not lose effectiveness over time, just like most meds do..b/c our bodies are trying to find homeostaiss all the time so why not with an AI as well, i mean it happens with some meds why not with AIs as well....

bump for more responces

 

[warrio2345]

I also got this but....

What do we know about the mechanisms of aromatase inhibitor resistance?

But it also says that this happens with tumors no longer responding, in using gear we are not fighting tumors but estro sides, so would that profoundly effect things. Since were basically going up against are body and not a tumor, it says the tumor no longer responded to it not that the AI just stop working...

I guess one thing as well is men who go on HRT stay on for 10-15 years or the rest of there lifes and they use Anti-estrogens while on hrt, so how can this be..

 

[ALIN]

Dont breath to much into the question just more for curisoity. Pros as most understand it, stay on gear year round. They use AI's (adex,letro,aroma) and stuff for 10 years at a time when you consider most started very young...
My question is do AI's over time lose potencty on your body or simply just stop working for you at some point or will AIs lose maybe lose a little efficeiency over the course of the years but negligable in terms of it actully effecting you in the sence that the AI no longer works...???

From my experience with using the AI's I have never seen or heard anything that
made me believe that they would lose their effectiveness.

 

[Varga]

For the original poster

I think that the reason you are having such a hard time understanding is prob because you dont understand the mechanics of how some of this meds work and their purpose in different environments.

you are asking the billion dollar question why shit doesnt work on cancers....if I knew I'll be rich bro..lol
I can prob broadly answer your question but it has nothing to do with bodybuilding and everything to do with cancer and cancerous cells!

 

[Zyglamail]

Im going to revive this since it still seems unanswered to the author and hopefully shed some light.

Studies like this one...

What do we know about the mechanisms of aromatase inhibitor resistance?

seem to give people the idea that AI's lose effectiveness but I think that is because some of the statements in the study are being applied out of context are at least partially out of context. Lets look at a coupel lines from the above study....

The article starts off with the following line...

Clinical trials have demonstrated the importance of aromatase inhibitor (AI) therapy in the effective treatment of hormone-dependent breast cancers. Yet, as with all prolonged drug therapy, resistance to aromatase inhibitors does develop.

By itself it would indicate they lose effectiveness, however right after the above quote is this.....

To date, the precise mechanism responsible for resistance to aromatase inhibitors is not completely understood. In this paper, several mechanisms of de novo/intrinsic resistance and acquired resistance to AIs are discussed. These mechanisms are hypothesized based on important findings from a number of laboratories.

It clearly states the mechanism responsible IS NOT understood and the mechanisms are hypothesized

A bit father down we see the following statement....

Almost all the data on acquired resistance are at present derived from laboratory studies. A major hypothesis is that the adaptation to estrogen withdrawal is involved in the resistance to both tamoxifen and AIs. Due to the ability of breast cancer cells to be adaptive, these endocrine therapies that function to block hormone-dependent signaling cascades required for breast cancer proliferation, may cause novel signaling mechanisms which circumvent the effects of an AI or anti-estrogen. An attractive hypothesis is that the resistance results from estrogen hypersensitivity or estrogen-independent activation of ER.

As well as this one....

There are two types of endocrine resistance. De novo/intrinsic resistance refers to lack of response at initial exposure to endocrine therapy of aromatase-positive and estrogen receptor (ER)-positive breast cancers. Acquired resistance is developed during endocrine therapy of patients who respond to the treatment initially. We and other investigators believe that elucidating the mechanisms of resistance to AIs/antiestrogens, on the molecular level, will be extremely valuable for the effective treatment of hormone-dependent breast cancers and for the development of novel approaches to treat patients who fail endocrine therapy.

Now I have to ask, what is cancer? Well, as deined by biology online.....

a cell that divides and reproduces abnormally with uncontrolled growth. This cell can break away and travel to other parts of the body and set up another site, referred to as metastasis.

What this study is talking about is the reduced effectiveness of AI's on tumors, cancerous tumors, cancer that divides and reproduces abnormally. If a study says that an E level remains constant for 7 months but its effectiveness falls to 33% after 6 months as I recall seeing in another study you posted, they are specifically referring to the AI's effectiveness against the cancer, not its effectivness at reducing E.

 

[lartinos]

Thanks zyg!