Nelson, a quick search gave me this article.
Neutralization of pregnancy-preventing activity of cabergoline, a dopamine agonist with progesterone
H. Negishi1, G. P. Kumar2, M. Laloraya2 and S. S. Koide3
1 Dept. of Obstetrics and Gynecology Hokkaido University School of Medicine, Sapporo, Japan 2 School of Life Sciences, Devi Ahilya Vishwavidyalaya, Indore, India 3 Center for Biomedical Research, The Population Council 1230 York Avenue, New York, NY 10021, USA
Received 3 September 1996; accepted 2 March 1997. ; Available online 17 December 1997.
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Abstract
Cabergoline (Cab), a dopamine agonist, inhibits the production and/or release of prolactin and reduces progesterone biosynthesis. Cab at doses of 20 μg/kg/d and higher administered on Days 1, 2 and 3 of pregnancy prevented implantation of fertilized ova in all treated female rats. The pregnancy-preventing activity of Cab is attributed to a deficiency of progesterone since estradiol levels remain unchanged. To validate the hypothesis that progesterone deficiency is the cause of the infertility, exogenous progesterone was administered to Cab-treated pregnant female rats and their fertility assessed. Progesterone at a dose of 5 mg/kg/d sc was administered on Days 1 to 7 of pregnancy to female rats treated with Cab (20 and 60 μg/kg/d) on Days 1, 2 and 3 of pregnancy. All progesterone-treated animals became pregnant, and all mated female rats treated with Cab (60 μg/kg/d) and progesterone (5 mg/kg/d) on Days 1 to 7 inclusive became pregnant. In conclusion, progesterone can neutralize the pregnancy preventing activity of Cab. Pregnant female rats treated with Cab can be used to assay for progestagenic activity of compounds.
Author Keywords: Cabergoline; dopamine agonist; progesterone; implantation of blastocysts; estradiol
Article Outline
• Referenceshttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TCM-3RJNS4Y-7&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=4ae3a1ccbcd0847bdf37530fe6e46fdb