too much vitamin C???

[Nonerz]

I recently bought a bottle of Chewable vitamin C from Trader Joe's...among lots of other things. They taste really good...and I've popped 2-3 of these baby's like nothing. They are 500 MG each...are there any negative sides and how much is too much?

 

[bignate73]

there are those that go up to 2-3 grams at times. you should be alright up to 1gram, flower.

you will pee out whatever you dont use with vit. c.

oil soluble vitamins are different. (vit. E, etc.)

you are working on that avatar arent ya baby?

 

[Millie]

too much vit C usually results in stomach cramps and diarrhea.

 

[bignate73]

here is some stuff from about.com

Vitamin C ASCORBIC ACID

Vitamin C is vital to collagen formation, the connective substance in all cells.

As an antioxidant, it helps defend cells from the effects of smoke, pollution and other highly reactive substances called free radicals.

Vitamin C helps in healing, in production of red blood cells, preventing haemorrhaging and in fighting bacterial infections. Physical stress increases the need for vitamin C.

Vitamin C can be found in fresh fruits (especially citrus) and berries, green vegetables, onions, tomatoes, radishes and rose hips.

Symptoms of this vitamin C deficiency are a tendency to bruising, swollen or painful joints, bleeding gums and nosebleeds.

Resistance to infection, and slow healing of wounds or illness are other symptoms, with severe lack being an old sailor's favourite of scurvy.

Effective with all vitamins and minerals calcium and magnesium.

from this article:
One common complaint regarding vitamin C is that it can cause gastrointestinal distress, including cramps, diarrhea and nausea. These symptoms, which are caused by the acidity rather than the ascorbate itself, seem to disappear when a buffered form of vitamin C is taken. In some cases, the chewable form of vitamin C also has led to erosion of dental enamel. In facilitating the absorption of iron, vitamin C can decrease the intake of copper and lead to a "negative copper balance," says Hathcock.

hope that helps...

 

[killa in manila]

just take some time released vit c,than and the rest of the stuff you eat during the day should suffice.

 

[MS]

Youshould cycle your intake of vitamin C. Otherwise your body adapts and you absorb less and less, causing you to become dependant on ever increasing doses just to stay healthy.

 

[anthrax]

Youshould cycle your intake of vitamin C. Otherwise your body adapts and you absorb less and less, causing you to become dependant on ever increasing doses just to stay healthy.

how do you cycle vitamin C ?

1 day on, 1 day off ?

1 week on, 1 week off ?

 

[anthrax]

Youshould cycle your intake of vitamin C. Otherwise your body adapts and you absorb less and less, causing you to become dependant on ever increasing doses just to stay healthy.

how do you cycle vitamin C ?

1 day on, 1 day off ?

1 week on, 1 week off ?

 

[danielson]

did read about vascular damage at doses above 500mg a day, but havent read anything about it since, so im nt sure if tu was true, or even verified

 

[anthrax]

did read about vascular damage at doses above 500mg a day, but havent read anything about it since, so im nt sure if tu was true, or even verified

it is true

Vitamin C exhibits pro-oxidant properties.

Podmore ID, et al.
Nature. 1998;392:559.

British researchers indicated that 500mg of Vitamin C given daily, could cause mutations in DNA of chromosomes that could lead to cancer or rheumatoid arthritis. When white blood cell lymphocytes of these human volunteers were tested and their DNA analyzed, one of the DNA nucleoside bases (adenine) was found to have been oxidized, however, another nucleoside base (guanine) received antioxidant protection.

AND

The Pro-oxidant and Antioxidant Effects of Vitamin C
by Jeffrey S. Bland, Ph.D.

The paper entitled, "Vitamin C Exhibits Pro-oxidant Properties," which appeared recently in the journal Nature has attracted considerable attention. Authors Podmore, Griffiths, Herbert, et al describe the potential pro-oxidant effects of daily supplementation with 500 mg of vitamin C on DNA base oxidation in vivo.1 Their conclusion raises concern because a vast number of individuals regularly supplement their diets with vitamin C in the belief that it has antioxidant effects.

The results of the study are paradoxical. The authors found that the oxidation of guanine (a purine) in DNA was significantly reduced after vitamin C supplementation, but the oxidation of adenine (also a purine) was significantly elevated. The oxidation of nucleic acids is indicative of oxidative stress being placed on DNA with the concomitant exposure to reactive oxygen species, such as hydroxyl radical. The oxidation of adenine suggests that vitamin C (supplemented at 500 mg) participated as a pro-oxidant, whereas the reduced level in the oxidation of guanine suggests it acted as an antioxidant.

Is vitamin C a pro-oxidant or an antioxidant? The answer to this question is not available from the data or its interpretation in the paper. The results are contradictory. The failure of the authors to point out this paradox in the conclusions drawn from their work is a significant oversight. They focus solely on the oxidation of adenine, and conclude that a supplement of 500 mg vitamin C acts as a pro-oxidant, while ignoring the observed antioxidant effects with regard to guanine. It is certainly well established that vitamin C can serve as a pro-oxidant through formation of ascorbyl radical. It is also known this radical is quenched by vitamin E to yield tocopheryl radical, which, in turn is reduced by the conversion of glutathione to oxidized glutathione. High doses of vitamin C could increase the concentration of ascorbyl radical that, if not quenched by vitamin E, could result in an increased oxidant burden. The observation in the Podmore et al study that guanine oxidation was reduced with supplementation of 500 mg vitamin C strongly suggests this was not the case. The presence of oxidized adenine remains a contradiction.

It has recently been pointed out that adenine is easily oxidized in the extraction procedure of lymphocytes for DNA.2 Therefore, it is possible that the observed adenine oxidation was not a result of vitamin C intake, but rather a result of experimental techniques used in the extraction of the DNA. Although the study opens the door for more investigation, it should not lead to the conclusion that a supplement of 500 mg vitamin C is dangerous. Until the apparent contradiction in the data relative to the oxidation of adenine versus the antioxidation of guanine is resolved, this paper simply represents an interesting observation in the absence of replication or mechanistic understanding.

References

1. Podmore ID, Griffiths HR, Herbert KE, et al. Vitamin C exhibits pro-oxidant properties. Nature 1998;392:559.

2. Jenner A, England TG, Aruoma OI, Halliwell B. Measurement of oxidative DNA damage by gas chromatography_mass spectrometry: ethanethiol prevents artifactual generation of oxidized DNA bases. Biochem J 1998;331:365-369.

Jeffrey S. Bland, Ph.D. is Chief Executive Officer of HealthComm International, Inc. Correspondence Address: HealthComm International, Inc., P. O. Box 1729, Gig Harbor, WA 98335.