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Amen to that! That is why I get blood works regularly. In fact, I really do not know why so many brothers around here do not get frequent blood works done.
SHBG (ways to decrease it)
- Thread starter Smokescreen
- Start date
Well, the last time i had my SHBG checked. I "believe" it was at 42-43. Pretty high if you ask me. I was ONLY taking 150mgs of Test cyp. Nothing else! Then I started to take 100mgs of proviron per day. 4 weeks later blood work said my SHBG dropped down to 30. Still high to be honest with you.
I've now added in Aromasin,HCG, DHEA and Masteron.
This week I should get my Post Cycle, Unleashed and HCGenerate. Along with Winny caps. I'm also going to switch from Test E to Test prop.
Maybe these "additions" will help drop that SHBG down to very low digits.
I must admit, that ever since I hit 31-32 years old, my SHBG levels have increased. And getting on Synthroid has made it worse. Even though my Thyroid levels are not high at all.
BTW..I put in another post a question. Why do they mean when a drug "binds" to SHBG? For example Masteron. They say Masteron binds to SHBG. But winny will lower it. What does "bind" mean? And how is that different to lowering it?
I've now added in Aromasin,HCG, DHEA and Masteron.
This week I should get my Post Cycle, Unleashed and HCGenerate. Along with Winny caps. I'm also going to switch from Test E to Test prop.
Maybe these "additions" will help drop that SHBG down to very low digits.
I must admit, that ever since I hit 31-32 years old, my SHBG levels have increased. And getting on Synthroid has made it worse. Even though my Thyroid levels are not high at all.
BTW..I put in another post a question. Why do they mean when a drug "binds" to SHBG? For example Masteron. They say Masteron binds to SHBG. But winny will lower it. What does "bind" mean? And how is that different to lowering it?
needtogetaas
New member
both hcgenerate and forma-stanzol lower shbg and so does unleashed. If you are a avid use of the products I formulate or sell then your shbg should never be a problem.
When SHBG "binds" to sex hormones (yes it binds to both test and estrogen) it makes them unable to do their job. Think of a receptor as a key hole and test/estrogen as keys. SHBG is gum that gets stuck on the key so it wont fit in the keyhole and hence cant unlock the lock. SHBG is another way for the body to control high levels of sex hormones, it binds to them temporarily and "saves" them for later use. High estrogen (even when test is low) can cause an abundance of SHBG, estrogen also has a binding affinity to AR receptors I believe but doesnt activate them and also high estrogen over time reduces the number of androgen receptors. So high E really can wreak havoc on things.
So me taking Masteron (binding the SHBG) and taking Winstrol as well (lowering SHBG) is a good combo?
needtogetaas
New member
It is a pointless combo. THey both do the same thing when it comes to shbg and IMO materone comes with way way less side effects and its cheaper. So its the better choice. Now if you wanted a drug that was highly effective at lowering shbg that can be used throughout a entire cycle then provirone is the shit. NOTHING!!! binds to shbg stronger. Well at least not any other drugs anyway.
However one of the main ingredents in hcgenerate does bind stronger to shbg.
3,4 Divanillyltetrahydrofuran....500 in each dose of hcgenerate. NOw Lets post the prof and studies showing that it lowers shbg. Just in case anyone felt like saying " supplements don't work lmao" you know there is always a pin head ready to make that claim lol.
3,4 divan has shown in multiple studies to have the highest binding affinity for SHBG of all lignans investigated thus far,Thus is lowers shbg and increases free test, and we threw in a huge dose of it.
3,4 Divanillyltetrahydrofuran
3,4-Divanillyltetrahydrofuran; A Potent Testosterone Booster
Interaction of lignans with human sex hormone binding globulin (SHBG).
Schottner M, Gansser D, Spiteller G.
Lehrstuhl Organische Chemie I, Universitat Bayreuth, Germany.
Lignans bind to sex hormone-binding globulin (SHBG). The lignan with the highest binding affinity is (+/ )-3,4-divanillyltetrahydrofuran. In a double condensation--without use of protecting groups--a wide variety of lignans with different substitution pattern in the aromatic and aliphatic part of the molecule was synthesized. These lignans were tested in a SHBG-binding assay which allowed to deduce the following relationship between structure and activity: 1)
(+/-)-diastereoisomers are more active than meso compounds 2.) the 4-hydroxy-3-methoxy (guajacyl) substitution pattern in the aromatic part is most effective 3.) the activity increases with the decline in polarity of the aliphatic part of the molecule.
Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG).
Schottner M, Gansser D, Spiteller G.
Lehrstuhl Organische Chemie I, Universitat Bayreuth, Germany.
Polar extracts of the stinging nettle (Urtica dioica L.) roots contain the ligans (+)-neoolivil, (-) secoisolariciresinol, dehydrodiconiferyl alcohol, isolariciresinol, pinoresinol, and 3,4 divanillyltetrahydrofuran. These compounds were either isolated from Urtica roots, or obtained semisynthetically. Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay. In addition, the main intestinal transformation products of plant lignans in humans, enterodiol and enterolactone, together with enterofuran were checked for their activity. All lignans except (-) pinoresinol developed a binding affinity to SHBG in the in vitro assay. The affinity of (-)-3,4 divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH).
3,4 Divanillyltetrahydrofuran also promote the secondary messenger nitric oxide (NO) by increasing its main enzyme eNOS (endothelial nitric oxide synthase). As NO is postulated to be one of the key triggers for muscle cell proliferation and growth while also promoting muscular pumps in the gym, this aspect of3,4 Divanillyltetrahydrofuran leads to fuller muscles that you can see and feel, thus providing significant mental motivation.
die faster
New member
so heres something ive never thought of until now.. can lowering SHBG cause a rise in estro?? since it binds to estro too? im assuming it cant be that bad cause this never seems to be a concern when just lowering shbg
SInce it binds to estro lowering SHBG lowers estrogen because there's less to bind to!
matter2003
Banned
LGD-4033 also lowers SHBG signicantly
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