SHBG (ways to decrease it)

[Smokescreen]

The only ways I know to "decrease" SHBG are...

High insulin levels
Low estrogen levels
Low thyroid hormones
And I believe high IGF-1 levels decreases it as well.

My question is....

Will taking MORE testosterone (while keeping E low with an AI) help to "decrease" SHBG?

 

[Smokescreen]

Hold up! Does taking HCG increase SHBG?

 

[Smokescreen]

I take synthroid. But my thyroid levels are normal. They are not high at all. Danazol. What is this drug? Do you have any info on it? Who carries it? I haven't seen this drug NOWHERE EVER!

 

[Nelson Montana]

Th most common and effective way to reduce SHBG vis drug use is Proviron.

The most common and effective way to reduce it naturally is UNLEASHED.

Both available and affordable.

Low thyroid can lower overall and free T.

Increased T will raise Free T but not exponentially. This is why some guys take a gram of gear and hardly grow. Adding a SHBG blocker will help tremendously.

 

[Smokescreen]

Weird thing is that my FREE test levels show up as high. They are well past the top of the referance range. I believe on the blood work it says that 25 is tops. Mines comes out to 41. But my SHBG is rather high. It's at 30! It was once at 44. So I began taking Proviron at 100mgs per day for a full month. Got blood work done and my SHBG only dropped from 44 down to 31. I was expecting it to go down my lower.

 

[Zyglamail]

Will taking MORE testosterone (while keeping E low with an AI) help to "decrease" SHBG?

generally speaking yes.

Stinging Nettle has shown in some studies to lower SHBG but it also has shown to block the action of the enzyme that converts test to DHT which in some folks can have its own sides.

Vitamin D deficiencies have shown to cause an increase in SHBG and reductions in natural test. If your an avid lifter you probably want your 25(OH)D levels in the 80-100ng/ml range anyway.

 

[Smokescreen]

My Vitamin D levels are fine. Had them checked out back in January. I take a calcium/D vitamin. And I make sure I get plenty of sun as well.

 

[Zyglamail]

My Vitamin D levels are fine. Had them checked out back in January. I take a calcium/D vitamin. And I make sure I get plenty of sun as well.

Fine and ideal are two different things. Keep in mind a serum test level of 300 is "fine" also. Each to their own.

 

[Smokescreen]

Damn. And the thing is that I don't have copies of that blood work. I just remember looking at it and saying..."Vitamin D levels are very nice".

 

[Zyglamail]

Damn. And the thing is that I don't have copies of that blood work. I just remember looking at it and saying..."Vitamin D levels are very nice".

One thing to consider when talking about macro-nutrient levels is athletes, and I use that term to simply describe people who religiously workout 5-7 days a week, often have higher nutritional demands than the "average" person.

With that in mind we generally want to be at the very top of the lab reference range.

 

[Smokescreen]

Amen to that! That is why I get blood works regularly. In fact, I really do not know why so many brothers around here do not get frequent blood works done.

 

[ceo]

Aromasin reduces SHBG quite well.

Needto's HCGenerate, with it's 3,4-divanillyltetrahydrofuran (extracted from nettle root), is also very effective at reducing or occupying SHBG.

 

[Smokescreen]

Well, the last time i had my SHBG checked. I "believe" it was at 42-43. Pretty high if you ask me. I was ONLY taking 150mgs of Test cyp. Nothing else! Then I started to take 100mgs of proviron per day. 4 weeks later blood work said my SHBG dropped down to 30. Still high to be honest with you.

I've now added in Aromasin,HCG, DHEA and Masteron.

This week I should get my Post Cycle, Unleashed and HCGenerate. Along with Winny caps. I'm also going to switch from Test E to Test prop.

Maybe these "additions" will help drop that SHBG down to very low digits.

I must admit, that ever since I hit 31-32 years old, my SHBG levels have increased. And getting on Synthroid has made it worse. Even though my Thyroid levels are not high at all.

BTW..I put in another post a question. Why do they mean when a drug "binds" to SHBG? For example Masteron. They say Masteron binds to SHBG. But winny will lower it. What does "bind" mean? And how is that different to lowering it?

 

[needtogetaas]

both hcgenerate and forma-stanzol lower shbg and so does unleashed. If you are a avid use of the products I formulate or sell then your shbg should never be a problem.

 

[Zyglamail]

BTW..I put in another post a question. Why do they mean when a drug "binds" to SHBG? For example Masteron. They say Masteron binds to SHBG. But winny will lower it. What does "bind" mean? And how is that different to lowering it?

When SHBG "binds" to sex hormones (yes it binds to both test and estrogen) it makes them unable to do their job. Think of a receptor as a key hole and test/estrogen as keys. SHBG is gum that gets stuck on the key so it wont fit in the keyhole and hence cant unlock the lock. SHBG is another way for the body to control high levels of sex hormones, it binds to them temporarily and "saves" them for later use. High estrogen (even when test is low) can cause an abundance of SHBG, estrogen also has a binding affinity to AR receptors I believe but doesnt activate them and also high estrogen over time reduces the number of androgen receptors. So high E really can wreak havoc on things.

 

[Smokescreen]

So me taking Masteron (binding the SHBG) and taking Winstrol as well (lowering SHBG) is a good combo?

 

[needtogetaas]

So me taking Masteron (binding the SHBG) and taking Winstrol as well (lowering SHBG) is a good combo?

It is a pointless combo. THey both do the same thing when it comes to shbg and IMO materone comes with way way less side effects and its cheaper. So its the better choice. Now if you wanted a drug that was highly effective at lowering shbg that can be used throughout a entire cycle then provirone is the shit. NOTHING!!! binds to shbg stronger. Well at least not any other drugs anyway.

However one of the main ingredents in hcgenerate does bind stronger to shbg.

3,4 Divanillyltetrahydrofuran....500 in each dose of hcgenerate. NOw Lets post the prof and studies showing that it lowers shbg. Just in case anyone felt like saying " supplements don't work lmao" you know there is always a pin head ready to make that claim lol.

3,4 divan has shown in multiple studies to have the highest binding affinity for SHBG of all lignans investigated thus far,Thus is lowers shbg and increases free test, and we threw in a huge dose of it.
3,4 Divanillyltetrahydrofuran
3,4-Divanillyltetrahydrofuran; A Potent Testosterone Booster
Interaction of lignans with human sex hormone binding globulin (SHBG).
Schottner M, Gansser D, Spiteller G.
Lehrstuhl Organische Chemie I, Universitat Bayreuth, Germany.

Lignans bind to sex hormone-binding globulin (SHBG). The lignan with the highest binding affinity is (+/ )-3,4-divanillyltetrahydrofuran. In a double condensation--without use of protecting groups--a wide variety of lignans with different substitution pattern in the aromatic and aliphatic part of the molecule was synthesized. These lignans were tested in a SHBG-binding assay which allowed to deduce the following relationship between structure and activity: 1)

(+/-)-diastereoisomers are more active than meso compounds 2.) the 4-hydroxy-3-methoxy (guajacyl) substitution pattern in the aromatic part is most effective 3.) the activity increases with the decline in polarity of the aliphatic part of the molecule.


Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG).
Schottner M, Gansser D, Spiteller G.
Lehrstuhl Organische Chemie I, Universitat Bayreuth, Germany.

Polar extracts of the stinging nettle (Urtica dioica L.) roots contain the ligans (+)-neoolivil, (-) secoisolariciresinol, dehydrodiconiferyl alcohol, isolariciresinol, pinoresinol, and 3,4 divanillyltetrahydrofuran. These compounds were either isolated from Urtica roots, or obtained semisynthetically. Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay. In addition, the main intestinal transformation products of plant lignans in humans, enterodiol and enterolactone, together with enterofuran were checked for their activity. All lignans except (-) pinoresinol developed a binding affinity to SHBG in the in vitro assay. The affinity of (-)-3,4 divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH).


3,4 Divanillyltetrahydrofuran also promote the secondary messenger nitric oxide (NO) by increasing its main enzyme eNOS (endothelial nitric oxide synthase). As NO is postulated to be one of the key triggers for muscle cell proliferation and growth while also promoting muscular pumps in the gym, this aspect of3,4 Divanillyltetrahydrofuran leads to fuller muscles that you can see and feel, thus providing significant mental motivation.

 

[die faster]

When SHBG "binds" to sex hormones (yes it binds to both test and estrogen) it makes them unable to do their job. Think of a receptor as a key hole and test/estrogen as keys. SHBG is gum that gets stuck on the key so it wont fit in the keyhole and hence cant unlock the lock. SHBG is another way for the body to control high levels of sex hormones, it binds to them temporarily and "saves" them for later use. High estrogen (even when test is low) can cause an abundance of SHBG, estrogen also has a binding affinity to AR receptors I believe but doesnt activate them and also high estrogen over time reduces the number of androgen receptors. So high E really can wreak havoc on things.

so heres something ive never thought of until now.. can lowering SHBG cause a rise in estro?? since it binds to estro too? im assuming it cant be that bad cause this never seems to be a concern when just lowering shbg

 

[Nelson Montana]

so heres something ive never thought of until now.. can lowering SHBG cause a rise in estro?? since it binds to estro too? im assuming it cant be that bad cause this never seems to be a concern when just lowering shbg

SInce it binds to estro lowering SHBG lowers estrogen because there's less to bind to!

 

[matter2003]

LGD-4033 also lowers SHBG signicantly

 

[matter2003]

so heres something ive never thought of until now.. can lowering SHBG cause a rise in estro?? since it binds to estro too? im assuming it cant be that bad cause this never seems to be a concern when just lowering shbg

No you have it reversed. Estrogen is the hormonal marker the body looks at for all its androgemic hormones, just as Leucine is the amino acid the body looks at to gauge protein levels...

Rises in estrogen cause rises in SHBG because the body thinks Testosterone levels are too high since the only way its programmed to make estrogen is by converting test. It doesn't realize that there are all kinds of environmental toxins and plastics that act as xenoestrogens that are wreaking havoc on male endocrine systems these days.

So high E levels lead to increased SHBG which lead to lower test levels. SHBG is created not as a response to Test, but as a response to increased Estrogen, which is normally aromatized from test, which is why these xenoestrogens cause so many issues since test levels aren't high but E levels are and the body still produces higher levels of SHBG in response