Here's what I dug up on this stuff. Let me know what your experiences are with this stuff as I'm considering taking it with my next cycle in a couple of weeks.
Avodart® (Dutasteride 0.5mg) is is a new generic version of the medication from GlaxoSmithKline for reducing DHT.
Dihydrotestosterone (DHT) is the main hormone linked to hairloss. Propecia® prevents one of two enzymes from being converted into DHT and blocks 2/3 of the DHT production. The new medication Avodart® blocks both enzymes in the body that convert into DHT and reduces overall DHT production by over 93%.
Avodart® comes in a 0.5mg softgel capsule that is taken by mouth once per day.
Propecia was originally approved under the name Proscar® for BPH and was only released for hair loss years later. Avodart has been approved for the treatment of Benign Prostatic Hyperplasia (BPH, or enlarged prostates) and is currently under study for approval for hair loss.
Avodart® at this dosage reduced DHT by 93.1-93.6% after 12-months on the medication. Scalp DHT was decreased 38% for Propecia®/Finasteride compared to 54% for 0.5mg Dutasteride.
Since Avodart® is currently being studied for hair loss, there are no exact figures on the percent of responders or results other than some of the sample photos released by the company from the studies. Results are expected to surpass Propecia's.
Our Avodart® is the original brand-name Avodart® 0.5mg from GlaxoSmithKline in the United States and is not a generic or international formulation.
Avodart® is not tested or approved for women and should not under any circumstances be taken by women who may become pregnant.
Safety Profile
The following side effects were noted during the large scale FDA trials of Avodart of over 5,000 men nationwide.
Actual %
(Dutasteride-Placebo)
Decreased Libio 2%
Impotence 3%
Ejaculation Disorder 2%
Sexual Function Disorder<1%
Gynecomastia < 1%
Other Issues:
• An analysis of the amount of Dutasteride found in the semen found it was far below the required levels to have any effect on a woman through sexual intercourse, so no warning will be included in the label regarding this. Studies showed that the amount of Dutasteride required in the semen to have an effect on a woman would be over a hundred times the level that was found to be present in semen. All pregnancies which occurred in patients participating in the studies produced healthy babies.
• Prostate Specific Antigen (PSA) levels were reduced 50% when taking the medication (the same as use of Propecia/Proscar/Finasteride). Men having their PSA levels checked will need to let the doctor know this and to double the results obtained by the test to evaluate the test results properly. PSA tests are routinely done to evaluate prostatic enlargement and other prostate conditions.
• Serum testosterone increased 20% on average, an amount which is not considered clinically significant.
• In studies of the effects on sperm, no significant changes were noticed in sperm morphology, sperm concentration, or sperm motility. Ejaculate volume decreased 25%, similar to Propecia, but stayed within the normal range. Two patients experienced a significant decrease in sperm count after the 52-week trial which reversed itself by the 26 week evaluation after the trial had ended.
• No toxic effects were found from the use of the medication.
• Although their studies indicated the amount passed in blood probably would not affect a pregnant female receiving a blood transfusion, it is recommended that men taking the medication not donate blood until they have stopped taking the medication for 6 months.
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