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kiwee
Banned
yeah, just wanted to see the diff, btwn dosages...only diff was the "hangover" was worse
delta sleep-inducing peptide; trial run
- Thread starter kiwee
- Start date
ArmaniAK47
New member
I can't sleep either...
it takes me at least an hour, sometimes 2-3 laying in bed to go down.. even after hard hard days and workouts an hour is good for me..
I also.. perhaps more annoyingly.. wake up like 16 times in the night...
god damn I hate it... > <
Valerian 1.5grams, Passion flower 500mgs and 3mg Melatonin helps me a LITTLE falling asleep and staying asleep..
I may try needto's sleep product soon..
it takes me at least an hour, sometimes 2-3 laying in bed to go down.. even after hard hard days and workouts an hour is good for me..
I also.. perhaps more annoyingly.. wake up like 16 times in the night...
god damn I hate it... > <
Valerian 1.5grams, Passion flower 500mgs and 3mg Melatonin helps me a LITTLE falling asleep and staying asleep..
I may try needto's sleep product soon..
DJ_UFO
Banned
RADAR
Well-known member
Delta sleep-inducing peptide, abbreviated DSIP, was first discovered in 1974 by the Swiss Schoenenberger-Monnier group who isolated it from the cerebral venous blood of rabbits in an induced state of sleep. It was primarily believed to be involved in sleep regulation due to its apparent ability to induce slow-wave sleep in rabbits, but studies on the subject have been contradictory.[1]
[edit] Structure and Interactions
DSIP is an amphiphilic peptide of molecular weight 850 daltons with the amino acid motif:
N-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-C[2]
It has been found in both free and bound forms in the hypothalamus, limbic system and pituitary as well as various peripheral organs, tissues and body fluids.[3] In the pituitary it co-localises with many peptide and non-peptide mediators such as corticotropin-like intermediate peptide (CLIP), adrenocorticotrophic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH) and melanin concentrating hormone (MCH). It is abundant in the gut secretory cells and in the pancreas where it co-localises with glucagon.[4]
In the brain its action may be mediated by NMDA receptors.[5]
It is unknown where DSIP is synthesized.
In vitro it has been found to have a low molecular stability with a half life of only 15 minutes due to the action of a specific aminopeptidase-like enzyme.[6] It has been suggested that in the body it complexes with carrier proteins to prevent degradation, or exists as a component of a large precursor molecule,[7] but as yet no structure or gene has been found for this precursor.
Evidence supports the current belief that it is regulated by glucocorticoids.[8]
Gimble et al. suggest that DSIP interacts with components of the MAPK cascade and is homologous to glucocorticoid-induced leucine zipper (GILZ).[9] GILZ can be induced by Dexamethasone. It prevents Raf-1 activation, which inhibits phosphorylation and activation of ERK. See [1] for image showing the pathway analysis of DSIP [10]
[edit] Function
Many roles for DSIP have been suggested following research carried out using peptide analogues with a greater molecular stability [11] and through measuring DSIP-like immunological (DSIP-LI) response by injecting DSIP antiserum and antibodies.[12]
[edit] Roles in endocrine regulation:
Decreases basal corticotropin level and blocks its release.[13]
Stimulates release of luteinizing hormone (LH).[14]
Stimulates release of somatoliberin and somatotrophin secretion and inhibits somatostatin secretion.[15]
[edit] Roles in physiological processes:
Can act as a stress limiting factor.[16][17][18]
May have a direct or indirect effect on body temperature and alleviating hypothermia.[19][20][21]
Can normalize blood pressure and myocardial contraction.[22].[23]
It has been shown to enhance the efficiency of oxidative phosphorylation in rat mitochondria in vitro, suggesting it may have antioxidant effects.[24]
There is also conflicting evidence as to its involvement in sleep patterns. Some studies suggest a link between DSIP and slow-wave sleep (SWS) promotion[25][26] and suppression of paradoxical sleep, (PS)[27][28]while some studies show no correlation.[29] Stronger effects on sleep have been noted for the synthesized analogues of DSIP.[30]
It may have an impact on human lens epithelial cell function via the MAPK pathway, which is involved in cell proliferation, differentiation, motility, survival, and apoptosis.[31]
[edit] Roles in Disease and Medicine
It has been found to have anticarcinogenic properties. In a study on mice, injecting a preparation of DSIP over the mice’s lifetime decreased total spontaneous tumor incidence 2.6-fold (Popovich et al. 2003).[32]
The same study found it to also have geroprotective effects: it slowed down the age-related switching-off of oestrous function; it decreased by 22.6% the frequency of chromosome aberrations in bone marrow cells and it increased by 24.1% maximum life span in comparison with the control group.
Levels of DSIP may be significant in patients diagnosed with major depressive disorder (MDD). In several studies, levels of DSIP in the plasma and cerebrospinal fluid are significantly deviated from the norm in patients with MDD, though there are contradictions as to whether levels are higher or lower than healthy control patients.[33][34][35]
Studies have demonstrated a direct link between GILZ expression (homologous to DSIP) and adipogenesis which has links to obesity and metabolic syndrome.[36]
In studies on rats with metaphit-induced epilepsy DSIP acted as an anticonvulsant, significantly decreasing the incidence and duration of fits suggesting DSIP as a potential treatment for epilepsy.[37] [38]
DSIP has been found to have an analgesic effect. In studies on mice it was found to have a potent antinociceptive effect when administered intracerebroventricularly or intracisternally (see: Route of administration).[39]
Due to its possible effects on sleep and nociception, trials have been carried out to determine whether DSIP can be used as an anaesthetic. One such study found that administration of DSIP to humans as an adjunct to isoflurane anaesthesia actually increased the heart rate and reduced the depth of anaesthesia instead of deepening it as expected.[40]
Low plasma concentrations of DSIP have been found in patients with Cushing's syndrome.[41]
In Alzheimer’s patients levels of DSIP have been found to be slightly elevated, though this is unlikely to be causal. (Torreilles and Touchon, 2002).[42]
A preparation of DSIP, Deltaran, has been used to correct central nervous system function in children after antiblastomic therapy. Ten children aged 3-16 years were given a ten-day course of Deltaran and their bioelectric activity recorded. It was found that the chemotherapy-induced impairment in the bioelectrical activity of 9 out of the 10 children was reduced by administration of DSIP (Sinyukhin et al. 2009).[43]
DSIP can act antagonistically on opiate receptors to significantly inhibit the development of opioid and alcohol dependence and is currently being used in clinical trials to treat withdrawal syndrome.[44] [45] In one such trial it was reported that in 97% of opiate-dependent and 87% of alcohol-dependent patients the symptoms were alleviated by DSIP administration.[46]
Studies have shown that administration of DSIP can alleviate narcolepsy and normalize disturbed sleeping patterns.[47] [48]
[edit] References
^ Schoenenberger GA, Maier PF, Tobler HJ and Monnier M (1977). "A naturally occurring delta-EEG enhancing nonapeptide in rabbits". European Journal of Physiology 369: 99-109.
^ Kovalzon VM and Strekalova TV (2006). "Delta sleep-inducing peptide (DSIP): a still unresolved riddle". Journal of Neurochemistry 97: 303–309.
^ Charnay Y, Bouras C, Vallet PG, Golaz J, Guntern R, Constantinidis J (1989). "Immunohistochemical distribution of delta sleep inducing peptide in the rabbit brain and hypophysis". Neuroendocrinology 49: 169–175.
^ Kovalzon VM and Strekalova TV (2006). "Delta sleep-inducing peptide (DSIP): a still unresolved riddle". Journal of Neurochemistry 97: 303–309.
^ Sudakova KV, Umriukhina PE, Rayevskyb KS (2004). "Delta-sleep inducing peptide and neuronal activity after glutamate microiontophoresis: the role of NMDA-receptors". Pathophysiology 11: 81–86.
^ Schoenenberger GA (1984). "Characterization, properties and multivariate functions of Delta-Sleep Inducing Peptide (DSIP)". European Neurology 23: 321–345.
^ Endogenous sleep substances and sleep regulation. Tokyo and BV, Utrecht, Netherlands: Japan scientific societies press, VNU science press. 1985.
^ Westrin A, Ekman R, and Traskman-Bendz L (1998). "High Delta Sleep-Inducing Peptide-Like Immunoreactivity in Plasma in Suicidal Patients with Major Depressive Disorder". Biological Psychiatry 43: 734-739.
^ Gimble JM, Ptitsyn AA, Goh BC, Hebert T, Yu G, Wu X, Zvonic S, Shi X-M and Floyd ZE (2009). "Delta sleep-inducing peptide and glucocorticoidinduced leucine zipper: potential links between circadian mechanisms and obesity?". Obesity reviews 10: 46–51.
^ © The Association for Research in Vision and Ophthalmology, Inc. (2007) Specific Activation of the Glucocorticoid Receptor and Modulation of Signal Transduction Pathways in Human Lens Epithelial Cells -- Gupta et al. 48 (4): 1724 Figure 4 -- Investigative Ophthalmology & Visual Science retrieved: 17/11/09
^ synthesized by V. N. Kalikhevich and S. I. Churkina, University Chemical Institute, St. Petersburg, Russia, and I. I. Mikhaleva and I. A. Prudchenko, Institute of Bio-organic Chemistry, Russian Academy of Sciences, Moscow
^ Charnay Y, Golaz J, Vallet PG, Bouras C (1992). "Production and immunohistochemical application of monoclonal antibodies against delta sleep-inducing peptide". J Chem Neuroanat 5: 503-9.
RADAR
needtogetaas
New member
Need2sleep kicks its fucking ass all night long!!!!!!!!.
needtogetaas
New member
Need 2 sleep
2 capsules per serving. 75 servings per bottle.
Sleep is the most essential aspects of our well being and health. Almost all cell regeneration and growth happens when we sleep. In other words we rest and repair when we sleep. When we don't get enough rest we don't get enough repair. When we don't get enough repair it takes its tole on our health.
A lack of regular healthy sleep slows down everything from brain function to muscle growth and its effects can be felt after just one night. When we don't get a good night sleep we feel sluggish,run down, and generally out of it untill we get the rest our bodies so desperately needs.
Not only is it important to get sleep but its equally important to get GOOD SLEEP . Uninterpreted healthy deep sleep. Often we may sleep 8-12 hours and still wake up feeling like we got no rest at all. This is because we did not fall into a deep restful sleep and stay there long enough.
Ever sleep 12 hours and feel like you didn't sleep a wink? this is because you did not reach a deep sleep or did not stay in a deep sleep long enough.
There are 2 basic stages in the sleep process. REM (Rapid Eye Movement) sleep and NREM (non-REM) sleep. NREM sleep is divided further into four sleep stages, numbered 1, 2, 3 and 4. Normal sleep begins with stage 1 and progresses into 2, 3 and 4, getting more and more deep with each stage. The deeper sleep is achieved at stages 3 and 4. (This is also the stage during which HGH and melatonin is released by the pineal gland). The fifth stage, which is actually lighter, is REM sleep, during which dreaming occurs.
The different sleep stages are also referred to as S-sleep (synchronized EEG pattern sleep) and D-sleep (desynchronized EEG pattern sleep). D-sleep is the same as REM or dream sleep; S-sleep is another name for NREM, ( also known as orthodox or quiet sleep).
The five stages of sleep:
Stage 1: As we fall asleep, we enter the transition state called stage 1 and begin our first "sleep cycle". This very light sleep stage usually lasts 2-5 minutes. If sleep remains undisturbed it will progress to stage 2 sleep. Stage 1 contributes 2-5 % of normal sleep, (but increases hugely in cases of insomnia and disorders that produce frequent arousal such as apnea) .
Stage 2: This is a much deeper sleep than stage 1. The brain waves go into theta mode, and lead into stages 3 and 4 in around 10-20 minutes. Stage 2 sleep occupies approximately 50-65% of our sleep time, lasting 15-30 minutes in each cycle.. During the latter part of the night we spend more and more time alternating between stages 2 & REM sleep.
Stage 3: A deeper sleep than stage 2. The muscles are relaxed, heart rate slows down, blood pressure falls, breathing is steady and even. Brain activity slows down dramatically from the theta pattern of stage 2 to a much slower rhythm of 1 to 2 cycles per second called 'delta', and the height, or amplitude, of the waves increases.
Stage 4: The deepest sleep of all, during which a sleeping person is 'dead to the world'. Blood pressure and heart rate fluctuate and the sleeper's brain heats up. Delta sleep is characterized by very high voltage slow brain waves. It is similar to being in a coma, but unlike a coma, it's reversible. As we transverse these first four stages of sleep our respiration and heart rate slow and the body is almost immobile.
Stage 5: REM (rapid eye movement). All of a sudden, after 20-30 minutes of slow wave sleep, we transfer back into stage 2, and almost immediately change gears into very active brain wave pattern known as REM sleep. Simultaneous with this transfer into REM, our respiration and heart rate increases substantially and we lose our ability to use our postural or skeletal muscles.
The first REM period lasts only about ten minutes. After that, the sleeper goes back into a deep stage 4 sleep. Again, the sleeper returns into a REM stage after a short period, and cycles through REM and stage 4 continue until the sleeper awakens. Along with this, our brain becomes so activated that we start to hallucinate and dream. Our eyes move as in wakefulness, and in relation to what we are dreaming. In effect, we are, at this stage ,a highly activated brain in a paralyzed body. This paradoxical state will last 10-20 minutes and then we "fall" back down into stage 2 again.
Needtobuildmuscle's Need 2 sleep is a 3 punch combo of ingredients designed to
1. promote relaxation
2. promote deep restful sleep
3. keep you in a deep restful stage of sleep longer
4. Have you waking up feeling better then ever with no groggy unnatural side effects.
The first ingredient in need 2 sleep is Valerian root. A full 400 powerful mg of it.
The major constituents of Valerian root include sesquterpenoids, valepotriates, bornyl acetate and valerenic acid. Multiple compounds in valerian root have pharmacologic activity. Valerenic acid has been shown to inhibit enzyme-induced breakdown and the inhibition of reuptake of the inhibitory neurotransmitter gamma-aminobutyric acid (gaba) in the brain. Basically this means that the brain chemical GABA can last longer and lead to sedation. Valerenic acid, an active constituent of valerian root extract, stimulates chloride currents through GABA( A) receptors. Valerenic acid is a subunit specific allosteric modulator of GABA (A) receptors that most likely interacts with the loreclezole binding pocket.
Clinical research shows that valerian root improves overall sleep quality, shortening the length of time it takes to fall asleep and helping people sleep more soundly. Overall, valerian root seems to help poor sleepers the most. In one double blind study on sleep disorders, 44 percent of the test group reported "perfect" sleep and 89 percent noted significant improvement after taking valerian root, in comparison with placebo
Lindahl O, Lindwall L. Double blind study of a valerian preparation. Pharmacology, Biochemistry & Behavior 1989; 32: 1065-1066.
The second ingredient in need 2 sleep is 6mg of Melatonin
Melatonin is a hormone produced naturally by the body in the pineal gland of the brain. The release of melatonin correlates with the body's cycle of day and night. As light inhibits its production, and darkness stimulates it, melatonin regulates the body's internal clock. Double blind research shows that this hormone helps people sleep, shortens the number of awakenings in the night, and improves the quality of sleep. melatonin exhibits positive psychological benefits on a person's mood, while a lack of melatonin corresponds to anxiety, fatigue, and hostility. In short it helps put you to sleep and bring you into a deep sleep faster.
The 3rd and final ingredient in need 2 sleep is is 5-htp 50mg
5-htp is the immediate precursor to serotonin a neurotransmitter. 5-hpt also increases endorphins our bodies natural pain killers.
5-HTP bypasses the brain's light-regulation system that controls the secretion of melatonin. 5-HTP results in the increased the production of neurotransmitters such as serotonin and norepinephrine that stimulate the noradrenergic receptors in the brain. This stimulation directly triggers the production and release of melatonin, helps relax the body,and prevents iritating pain from keeping you awake.
Combined, the ingredients in need 2 sleep are a proven powerful sleep aid. Need 2 sleep will put you to sleep fast and give you the good nights rest your body needs.
"These statements have not been evaluated by the Food & Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease."
2 capsules per serving. 75 servings per bottle.
Sleep is the most essential aspects of our well being and health. Almost all cell regeneration and growth happens when we sleep. In other words we rest and repair when we sleep. When we don't get enough rest we don't get enough repair. When we don't get enough repair it takes its tole on our health.
A lack of regular healthy sleep slows down everything from brain function to muscle growth and its effects can be felt after just one night. When we don't get a good night sleep we feel sluggish,run down, and generally out of it untill we get the rest our bodies so desperately needs.
Not only is it important to get sleep but its equally important to get GOOD SLEEP . Uninterpreted healthy deep sleep. Often we may sleep 8-12 hours and still wake up feeling like we got no rest at all. This is because we did not fall into a deep restful sleep and stay there long enough.
Ever sleep 12 hours and feel like you didn't sleep a wink? this is because you did not reach a deep sleep or did not stay in a deep sleep long enough.
There are 2 basic stages in the sleep process. REM (Rapid Eye Movement) sleep and NREM (non-REM) sleep. NREM sleep is divided further into four sleep stages, numbered 1, 2, 3 and 4. Normal sleep begins with stage 1 and progresses into 2, 3 and 4, getting more and more deep with each stage. The deeper sleep is achieved at stages 3 and 4. (This is also the stage during which HGH and melatonin is released by the pineal gland). The fifth stage, which is actually lighter, is REM sleep, during which dreaming occurs.
The different sleep stages are also referred to as S-sleep (synchronized EEG pattern sleep) and D-sleep (desynchronized EEG pattern sleep). D-sleep is the same as REM or dream sleep; S-sleep is another name for NREM, ( also known as orthodox or quiet sleep).
The five stages of sleep:
Stage 1: As we fall asleep, we enter the transition state called stage 1 and begin our first "sleep cycle". This very light sleep stage usually lasts 2-5 minutes. If sleep remains undisturbed it will progress to stage 2 sleep. Stage 1 contributes 2-5 % of normal sleep, (but increases hugely in cases of insomnia and disorders that produce frequent arousal such as apnea) .
Stage 2: This is a much deeper sleep than stage 1. The brain waves go into theta mode, and lead into stages 3 and 4 in around 10-20 minutes. Stage 2 sleep occupies approximately 50-65% of our sleep time, lasting 15-30 minutes in each cycle.. During the latter part of the night we spend more and more time alternating between stages 2 & REM sleep.
Stage 3: A deeper sleep than stage 2. The muscles are relaxed, heart rate slows down, blood pressure falls, breathing is steady and even. Brain activity slows down dramatically from the theta pattern of stage 2 to a much slower rhythm of 1 to 2 cycles per second called 'delta', and the height, or amplitude, of the waves increases.
Stage 4: The deepest sleep of all, during which a sleeping person is 'dead to the world'. Blood pressure and heart rate fluctuate and the sleeper's brain heats up. Delta sleep is characterized by very high voltage slow brain waves. It is similar to being in a coma, but unlike a coma, it's reversible. As we transverse these first four stages of sleep our respiration and heart rate slow and the body is almost immobile.
Stage 5: REM (rapid eye movement). All of a sudden, after 20-30 minutes of slow wave sleep, we transfer back into stage 2, and almost immediately change gears into very active brain wave pattern known as REM sleep. Simultaneous with this transfer into REM, our respiration and heart rate increases substantially and we lose our ability to use our postural or skeletal muscles.
The first REM period lasts only about ten minutes. After that, the sleeper goes back into a deep stage 4 sleep. Again, the sleeper returns into a REM stage after a short period, and cycles through REM and stage 4 continue until the sleeper awakens. Along with this, our brain becomes so activated that we start to hallucinate and dream. Our eyes move as in wakefulness, and in relation to what we are dreaming. In effect, we are, at this stage ,a highly activated brain in a paralyzed body. This paradoxical state will last 10-20 minutes and then we "fall" back down into stage 2 again.
Needtobuildmuscle's Need 2 sleep is a 3 punch combo of ingredients designed to
1. promote relaxation
2. promote deep restful sleep
3. keep you in a deep restful stage of sleep longer
4. Have you waking up feeling better then ever with no groggy unnatural side effects.
The first ingredient in need 2 sleep is Valerian root. A full 400 powerful mg of it.
The major constituents of Valerian root include sesquterpenoids, valepotriates, bornyl acetate and valerenic acid. Multiple compounds in valerian root have pharmacologic activity. Valerenic acid has been shown to inhibit enzyme-induced breakdown and the inhibition of reuptake of the inhibitory neurotransmitter gamma-aminobutyric acid (gaba) in the brain. Basically this means that the brain chemical GABA can last longer and lead to sedation. Valerenic acid, an active constituent of valerian root extract, stimulates chloride currents through GABA( A) receptors. Valerenic acid is a subunit specific allosteric modulator of GABA (A) receptors that most likely interacts with the loreclezole binding pocket.
Clinical research shows that valerian root improves overall sleep quality, shortening the length of time it takes to fall asleep and helping people sleep more soundly. Overall, valerian root seems to help poor sleepers the most. In one double blind study on sleep disorders, 44 percent of the test group reported "perfect" sleep and 89 percent noted significant improvement after taking valerian root, in comparison with placebo
Lindahl O, Lindwall L. Double blind study of a valerian preparation. Pharmacology, Biochemistry & Behavior 1989; 32: 1065-1066.
The second ingredient in need 2 sleep is 6mg of Melatonin
Melatonin is a hormone produced naturally by the body in the pineal gland of the brain. The release of melatonin correlates with the body's cycle of day and night. As light inhibits its production, and darkness stimulates it, melatonin regulates the body's internal clock. Double blind research shows that this hormone helps people sleep, shortens the number of awakenings in the night, and improves the quality of sleep. melatonin exhibits positive psychological benefits on a person's mood, while a lack of melatonin corresponds to anxiety, fatigue, and hostility. In short it helps put you to sleep and bring you into a deep sleep faster.
The 3rd and final ingredient in need 2 sleep is is 5-htp 50mg
5-htp is the immediate precursor to serotonin a neurotransmitter. 5-hpt also increases endorphins our bodies natural pain killers.
5-HTP bypasses the brain's light-regulation system that controls the secretion of melatonin. 5-HTP results in the increased the production of neurotransmitters such as serotonin and norepinephrine that stimulate the noradrenergic receptors in the brain. This stimulation directly triggers the production and release of melatonin, helps relax the body,and prevents iritating pain from keeping you awake.
Combined, the ingredients in need 2 sleep are a proven powerful sleep aid. Need 2 sleep will put you to sleep fast and give you the good nights rest your body needs.
"These statements have not been evaluated by the Food & Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease."
kiwee
Banned
yup, but just figured its something i would try....although the allergic reaction is scaring me
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