Frackal said:
Your linking is pretty specious buddy... stress depresses the immune system as well... steroids are not carcinogenic.
Also, what exactly are the details behind 'excessive steroid application' and what and where were the 'malignant tumors' formed?
Based on my limited knowledge, I was wrong to imply all steroids inhibit the effectiveness of the immune system via the thymus gland in animals.
I should have been more precise. Long term effects of sustained corticosteroid application suppress immune system response in lab rats, resulting in a significant increase in the onset of terminal disease.
The immunosuppressive effects of corticosteroids on the thymus gland is theorized to decrease long term ability of the thymus to produce thymic hormones, inhibiting efficient function of the immune system.
To be honest frackal, i dont know a whole lot about endocrinology, except what i studied in university.
But responding to your comment that steroids are not carcinogenic (in humans? or animals? or both?). I dont know if id go this far.
The relevance of what i said in my earlier post still holds. The overwhelming majority of reliable experiments investigating long term effects of steroid use is limited to studies using animal subjects.
I suppose this can be interpreted both ways. But the 'experiments' investigating long term effects of steroid use in humans, to my knowledge, are fraught with methodological aberrations, which makes any claims resulting from these experiments, highly dubious.
After reading your response, i found a webpage called toxnet which has a database of chemicals and their associated toxicology rating, carcinogenic properties, ect.
http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?Multi
The database includes listings for both anabolic and catabolic steroids. Relevant animal toxicology studies accompany information listings about certain steroids, with some experimental abstracts indicating said steroid exhibit carcinogenic characteristics.
To be thorough we'd have to go over the experimental methodology of the studies in question, and then assess how valid these results are to humans in light of differing physiology of the subjects used.
I know this post is getting kinda long. But the points were touching upon in our conversation reminded me of a long time ago, when I used to be really pro E and was popping hits twice or three times a month.
Neuroscientists started saying E caused brain damage. I scoffed. How could they know? They have no casual evidence suggesting such a link, and reliable experimental studies conducted used animals whose physiology differs from humans.
After going through the relevant experiments using subjects from rats to primates, and seeing similar effects all the way through, it dawned on me, I was supporting a position not because the data suggested it, but because i wanted to believe it.