READ THE STUDY FIRST, BEFORE YOU POST IT
Caffeine-induced impairment of glucose tolerance is abolished by -adrenergic receptor blockade in humans
Farah S. L. Thong and Terry E. Graham
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
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FIRST NOTE: THIS STUDY WAS DONE IN CANADA...I WENT THROUGH MY Ph.D MANUAL AND TRIED TO LOOK UP Farah S. L. Thong AND Terry E. Graham....NOTHING CAME UP! IF THEY ARE NOT QUALIFIED TO DO STUDIES, THEY ARE A WASTE OF TIME TO READ...BUT I'LL GO ON
The caffeine-induced impairment of insulin action is commonly attributed to adenosine receptor (AR) antagonism in skeletal muscle.
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COMMONLY ATTRIBUTED, DOESN'T MEAN IT'S TRUE
However, epinephrine, a potent inhibitor of insulin actions, is increased after caffeine ingestion.
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THIS IS ONLY TRUE IN SOME USERS; IN OTHERS, THAT HAVE USED CAFFEINE FOR A LONGER PERIOD OF TIME. EPINEPHRINE ACTIONS ARE NON-EXISTANT
We tested the hypothesis thatthe insulin antagonistic effects of caffeineare mediated by epinephrine, and not by AR antagonism,
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EARTH TO _JAAP_.....THEY TESTED THE HYPOTHESIS, IT DOES NOT MEAN IT'S TRUE KEY WORK: HYPOTHESIS
in seven healthy men.
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WEIGHT? AGE? EXPERIENCE W/ CAFFEIN? NOT ENOUGH VARIABLES!!!
On four separate occasions, they received 1) dextrose (placebo, PL),
DEXTROSE AS A PLACEBO? WHY? IDIOTIC
2) 5 mg/kg caffeine (CAF),
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JESUS, THEY GAVE THESE PEOPLE (AVR 200LB MALE AS AN EXAMPLE) WHAT AROUND 500MG CAFFEINE, OF COURSE YOUR SYSTEM IS GOING TO RESPOND DIFFERENTLY, ESPECIALLY FOR FIRST TIME USERS
3) 80 mg of propranolol (PR), and 4) 5 mg/kg caffeine + 80 mg of propranolol (CAF + PR) before an oral glucose tolerance test (OGTT). Blood glucose was similar among trials before and during the OGTT. Plasma epinephrine was elevated (P < 0.05) in CAF and CAF + PR. Areas under the insulin and C-peptide curves were 42 and 39% greater (P < 0.05),
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THEY HAVE VAGUE WORDING HERE, BUT IT SEEMS THAT THE LEVELS ARE ONLY 3% OFF, WHICH IS NOTHING, CONSIDERING MOST STUDIES HAVE A FAILSAFE 1-10% MARGIN
respectively, in CAF than in PL, PR, and CAF + PR. In the presence of propranolol (CAF + PR), these responses were similar to PL and PR. These data suggest that the insulin antagonistic effects of caffeine in vivo are mediated by elevated epinephrine rather than by peripheral AR antagonism.
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SO WHAT? THIS THEORY PROVES NOTHING; CAN WE SAY THE GLUCOSE KREB CYCLE WAS DISRUPTED IN SOME WAY! WERE THE MEN W/ AN EMPTY STOMACH WHEN THEY DID THIS! TOO MANY THINGS NOT SHOWN
note that in this study they took the insuline impairment as a given. Which means this theory has at LEAST some proliferation among the medical community.
There are actually a lot of studies which i saw, but im too lazy to dig em all up so i just posted one.
JUST BECAUSE IT'S SAYING THAT, IT DOESN'T MEAN IT'S "LEAST" TRUE; I CAN MAKE A STUDY SAYING YOUR NOSE GROWS FROM LYING AND MEASURE NOSE GROWTH IN CHILDREN FROM THE AGE OF 4-10, OF COURSE THEIR NOSES WILL GROW....THESE ARE SUCH PRE-MEDSCHOOL ASSUMPTIONS
But this one is particulary interesting cause as u said caffeine is a nervous system stimulant (among others increased epinephrine release) which seems to be the cause of the effect of insuline.
THEORY, NOT STUDY
I guess in first time users, one can say it have a little bit of a "desensitizing" effect, but it's over-ruled by the stimulatory effect.
Mr.X