str8cubano said:
had a horrible weekend, don't remember the night very well, and somehow some way i was given lsd. I was up for the whole day, for about roughly 14 hours, probably the worst feeling of my life. anyways, i needed to go to sleep, and my mom takes anti depressants, and gave me zyprexa. From what my freind says, zyprexa stays in your system for at least 4-5 days (he's studying pharmacy). This happend friday night, and i took zyprexa saturday at around 11:30 pm. HOw long can the effects possibly last, becuase today i still feel tired, unmotivated, really lazy. I want to hit the gym but don't know if i should.
Olanzapine
Olanzapine (Zyprexa)
Olanzapine
((oh-LAN-zah-peen))
Pregnancy Category: C Zyprexa (Rx)
Classification: Antipsychotic agent, miscellaneous
Action/Kinetics: A thienbenzodiazepine antipsychotic believed to act by antagonizing dopamine D1-4 and serotonin (5HT2) receptors. Also binds to muscarinic, histamine H1, and alpha-1 adrenergic receptors, which can explain many of the side effects. Well absorbed from the GI tract. Peak plasma levels: 6 hr after PO dosing. Undergoes significant first-pass metabolism with about 40% metabolized before it reaches the systemic circulation. Food does not affect the rate or extent of absorption. Significantly bound to plasma proteins. Unchanged drug and metabolites are excreted through both the urine and feces.
Uses: Management of psychotic disorders. Investigational: Treatment of acute mania associated with bipolar I disorder.
Contraindications: Lactation.
Special Concerns: Use with caution in geriatric clients, as the drug may be excreted more slowly in this population. Use with caution in impaired hepatic function and in those where there is a chance of
increased core body temperature (e.g., strenuous exercise,exposure to extreme heat, concomitant anticholinergic drug administration, dehydration). Due to anticholinergic side effects, use with caution in clients with
significant prostatic hypertrophy, narrow-angle glaucoma, or a history of paralytic ileus. Safety and efficacy have not been determined in children less than 18 years of age.
Laboratory Test Alterations:
ALT, AST, GGT, alkaline phosphatase, serum prolactin, eosinophils, CPK. Hyperprolactinemia.
Overdose Management: Symptoms: Drowsiness, slurred speech. Possible obtundation, seizures, dystonic reaction of the head and neck. CV symptoms, arrhythmias. Treatment: Establish and maintain an airway and ensure adequate oxygenation and ventilation. Gastric lavage followed by activated charcoal and a laxative can be considered, although dystonic reaction may cause aspiration with induced emesis. Begin CV monitoring immediately with continuous ECG monitoring to detect possible arrhythmias. Hypotension and circulatory collapse are treated with IV fluids or sympathomimetic agents. Do not use epinephrine, dopamine, or other sympathomimetics with
beta-agonist activity, as beta stimulation may worsen hypotension.
Antagonism of dopamine D1-4 receptors..probably causing the hyperprolactinemia.
Antagonism of the muscarinic M1-5 receptors are responsible for the anti-cholinergic effects...dry mouth, constipation, blurred vision, impaired memory and compromised cognitive abilities as well as decreased neural-muscular activity exactly the opposite of what we're trying to achieve with supps. like ALCar,choline, and lecithin.
Antagonism of the alpha1 receptors will cause orthostatic hypotension, causing dizziness.
The anti-cholinergic and anti-histamine effects is responsible for you feeling tired,weak,dizzy and unmotivated.
The mean elimination half-life of the drug is 30 hrs. as mentioned by JJ. so 5 half lives could take 6-7 days.
I'm not positive as to the effects of the lysergic acid/zyprexa combo, but I managed to find some info on Risperidone/lysergic acid, where risperidone is an anti-psychotic with similar mechanism of action as zyprexa.
LSD-like panic from risperidone in post-LSD visual disorder.
Abraham HD, Mamen A.
Department of Psychiatry, Tufts University School of Medicine, Boston, Massachusetts, USA.
Risperidone, a novel antipsychotic agent, is an antagonist of postsynaptic serotonin-2 and dopamine D2 receptors. In certain individuals, the hallucinogenic drug lysergic acid diethylamide (LSD) is associated with apparently lifelong continuous visual disturbances, characterized in DSM-IV as hallucinogen-persisting perception disorder (HPPD). Because the hallucinogenic mechanism of LSD is known to act in part at postsynaptic serotonin-2 receptors, it is noteworthy that three HPPD patients treated with risperidone reported an exacerbation of LSD-like panic and visual symptoms. We conclude that HPPD may be a relative contraindication for the use of risperidone.
Be Careful next time bro....Peace B32
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