Wow I really got my a** kicked in this post - even though I thought I had it all figured out. I want to thank you guys for taking the time. Its appreciated.
Regarding the PCT which seems to be the biggest issue I would like to explain why I have selected it to be like this.
Obviously Ill be needing aSERM – I have chosen Nolvadex because it has estrogenic effects, it lowers cholesterol-, as well as preventing gynocomastia by preventing oestrogen gene transcription in breast tissue. It acts as an anti-oestrogen in the pituitary, thus increasing LH and FSH, which result in an increase in testosterone. 20mgs of Nolvadex is said to increase testosterone levels about 150%.
In hypogonadic and infertile men given nolvadex, increases in the serum levels of LH, FSH, and most importantly, testosterone were all observed. It can also block a bit of estrogen in the pituitary, which is a great benefit when used with HCG.
HCG stimulates the by initiating gene transcription that is identical to that of Luetenizing Hormone, thereby causing the Leydig Cells to produce testosterone. This way I can stimulate LH and FSH production with Nolvadex, and then directly stimulate the Leydig Cells as well, to produce testosterone by different routes.
While HCG increases Testosterone, it increases estrogen as well. Unfortunately, the downregulation of the Leydig Cell LH receptor itself, seems to also play a role in high dose HCG testicular desensitization. This is also done by HCG actually blocking the conversion of 17 alpha-hydroxyprogesterone to testosterone. Nolvadex stops this blocking-action of HCG from taking place because of Nolvadex’s direct antiestrogenic effect and LH-upregulating effect on the Pituitary, suppression of gonadotropins via HCG is almost totally stopped with concurrent administration of Nolvadex
Now there there’s the issue of estrogen caused by that HCG-stimulated surge in testosterone. I could use low doses (300iu or so) to avoid some of that major spike in estrogen, and thus cause far less inhibition from the HCG but I would be using a bit more HCG per injection (500iu) to get my body functioning fully more quickly.
Im adding AI because it makes estrogen receptors useless, and instead of just inhibiting production it cuts off production totally. Aromasin can effectively remove up to about 85%+ of estrogen from your body. Most importantly, using Aromasin together with Nolvadex doesn’t reduce exemestane’s effectiveness. I think the problem of ANY inhibition possible with HCG is solved why I can use that 500iu/day dose that I wanted to use previously. With this PCT, there will be a rapid increase in LH, FSH, and testosterone, as well as almost a complete block on all the factors that could be causing natural hormones to be delayed in returning to baseline.
Does that make sense or am I screwed?