What's the truth on peptides, old school hgh guy??

[purestrong1910]

Been using Real hgh off and on for many years, love it but real hgh means Real expensive, transit from overseas, or resellers that who knows how long it was being destroyed by weeks of heat in transit, etcetera., I keep reading about all these peptides on the boards, new to elite but see lots of respectable info here. What's the truth not just from the biggest guy in the gym or best looking avatar.


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[1ugafreak]

I hear you, took me a long time to even consider trying peptides, seemed too cheap compared to hgh and hgh worked for so many years.

Ok, hgh best works if it is released in a pulsitile manner, meaning you want a high peak of release at the right time for it to work best. A high amplitude pulse causes more IGF-1 release and the whole "grow big muscles" cascade.

GHRH like Sermorelin which is a close relative or analogue promotes the release of hgh by working on the hypothalamus that then signals the pituitary by way of messenger cAMP to release more HGH from within the cells it is produced the somatotrophs(that's what we want), fancy words for how this works.

The second part and I'm really just skimming the info here. We need a GHRP, a ghrelin analogue to produce more intracellular Hgh by its messenger PKC which gets pushed to be released by the GHRH previously discussed. Ghrelin works in the stomach(simplified). GHRP's in addition to increasing hgh in the cells, increase gastric motility/secretion, modulate pancreas and immunity, glucose, sleep and behavior etc., GHRP-6 stimulates appetite more than GHRP-2 so remember this if dieting.
As a person ages their is less GHRP to release the GHRH(sermorelin) that does not decline as quickly. So at night the decrease of slow wave sleep as we age or party like rock stars shuts this down. So here we see how we can tie in DSIP( delta sleep inducing peptide) into the formula. I hope this is tying things together for folks.
When do we want this pulse, lots of theories. I like to theorize that it is best to add this pulse to the natural physiologic pulse the body produces. We get a pulse post workout, at times of low glucose, during slow wave sleep and we add to this pulse by using Sermorelin and a GHRP.

Let me sum this up, by using HGH for long periods we speed the aging of the hypothalamus and the pituitary(they shrink) due to a strong negative feedback system that shuts them down when they sense actually injected HGH. Because we inject hgh subq or even IV we never really get the best pulse that the GHRH and GHRP's produce. It gets slowly released either way, it exits the body faster IV but does not create a greater pulse. Use of GHRH and GHRP work best together. You need to stimulate the production within the cell AND the release from the cell into circulation. So not only do we get this benefit but the combo actually restores the natural physiologic production and pulsitile release from the glands we have shrunk and beat up during our HGH usage....
I've used lots of GHRH's and GHRP's I can't speak for other companies but I have used pinnaclepeptides.com products over the years and the products they offer are manufactured in the USA from the highest quality USA sourced raw ingredients.
And cant beat their current sales...

Any questions on using GHRH's, GHRP's, DSIP or other products not already answered by one of the reps of pinnacle please PM me and I can answer them personally.

Thanks








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[SoCalMK6GTI]

I hear you, took me a long time to even consider trying peptides, seemed too cheap compared to hgh and hgh worked for so many years.

Ok, hgh best works if it is released in a pulsitile manner, meaning you want a high peak of release at the right time for it to work best. A high amplitude pulse causes more IGF-1 release and the whole "grow big muscles" cascade.

GHRH like Sermorelin which is a close relative or analogue promotes the release of hgh by working on the hypothalamus that then signals the pituitary by way of messenger cAMP to release more HGH from within the cells it is produced the somatotrophs(that's what we want), fancy words for how this works.

The second part and I'm really just skimming the info here. We need a GHRP, a ghrelin analogue to produce more intracellular Hgh by its messenger PKC which gets pushed to be released by the GHRH previously discussed. Ghrelin works in the stomach(simplified). GHRP's in addition to increasing hgh in the cells, increase gastric motility/secretion, modulate pancreas and immunity, glucose, sleep and behavior etc., GHRP-2 stimulates appetite more than GHRP-6 so remember this if dieting.
As a person ages their is less GHRP to release the GHRH(sermorelin) that does not decline as quickly. So at night the decrease of slow wave sleep as we age or party like rock stars shuts this down. So here we see how we can tie in DSIP( delta sleep inducing peptide) into the formula. I hope this is tying things together for folks.
When do we want this pulse, lots of theories. I like to theorize that it is best to add this pulse to the natural physiologic pulse the body produces. We get a pulse post workout, at times of low glucose, during slow wave sleep and we add to this pulse by using Sermorelin and a GHRP.

Let me sum this up, by using HGH for long periods we speed the aging of the hypothalamus and the pituitary(they shrink) due to a strong negative feedback system that shuts them down when they sense actually injected HGH. Because we inject hgh subq or even IV we never really get the best pulse that the GHRH and GHRP's produce. It gets slowly released either way, it exits the body faster IV but does not create a greater pulse. Use of GHRH and GHRP work best together. You need to stimulate the production within the cell AND the release from the cell into circulation. So not only do we get this benefit but the combo actually restores the natural physiologic production and pulsitile release from the glands we have shrunk and beat up during our HGH usage....
I've used lots of GHRH's and GHRP's I can't speak for other companies but I have used pinnaclepeptides.com products over the years and the products they offer are manufactured in the USA from the highest quality USA sourced raw ingredients.
And cant beat their current sales...

Any questions on using GHRH's, GHRP's, DSIP or other products not already answered by one of the reps of pinnacle please PM me and I can answer them personally.

Thanks








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Damn bro. Answers like this are what keep me on this forum and away from others. The knowledge and maturity of (most) members is just incomparable.

Great response.