Yohimbine with ECA question

[SlimJim300]

Lots of you guys take yohimbine HCL with your E/C stack, which is a good idea. However, I have heard that taking yohimbine and ephedrine at the same time can cause the heart to race out of control. So do you take them together or separate (I hear 4 hours apart), and at what dosage?

I have decided that if I were to not take them at the same time, it would be best to take yohimbine (.2 mg/kg) with no-carb meals and take the E/C with carb meals (and/or no-carb meals) since insulin negates yohimbines effects. Anyway, my main concern here is that I don't want to risk developing a resistance to either of these drugs, or worse yet, damage my heart and nervous system like an amphetamine junkie. Thanks much in advance.

 

[yomama]

Lots of you guys take yohimbine HCL with your E/C stack, which is a good idea. However, I have heard that taking yohimbine and ephedrine at the same time can cause the heart to race out of control. So do you take them together or separate (I hear 4 hours apart), and at what dosage?

I have decided that if I were to not take them at the same time, it would be best to take yohimbine (.2 mg/kg) with no-carb meals and take the E/C with carb meals (and/or no-carb meals) since insulin negates yohimbines effects. Anyway, my main concern here is that I don't want to risk developing a resistance to either of these drugs, or worse yet, damage my heart and nervous system like an amphetamine junkie. Thanks much in advance.

You sure you're not talking about Yohimbe?

 

[SlimJim300]

Yohimbine is the main active alkaloid in yohimbe. Yohimbine blocks the alpha2 receptor, so there is less inhibition of the release of norepinephrine. Ephedrine stimulates the release of norepinephrine. Since norepinephrine binds to both the alpha and beta receptors, yohimbine basically makes ephedrine's actions more potent by blocking norepinephrine from the alpha2. But is it too much?

 

[junk]

bump. good question!

 

[bdog527]

I take 6mgs. of yohimbine with 25mgs. of ephedrine and 200mgs. of caffiene 3 times a day when cutting. In fact I just washed down a dose with some diet coke.

I have never had a problem tolerating this combo. I do my runs while on it and my lifts are fine. My heart rate is usually only slightly elevated and bp is usually normal while on the stuff. I guess it probably just boils down to individual tolerance but your bf% would also have a lot to do with it. I also seem to tolerate stimulates pretty well it seems.

 

[SlimJim300]

Thanks for the input bdog!

 

[Smokescreen]

I do the same thing as bdog...but without the diet coke of course and all is fine.

 

[SlimJim300]

Okay this morning I went with 25mg ephedrine, 200mg caffeine, and 6mg yohimbine. (I also took with my regular nootropic stack -- 800mg piracetem, 10mg vinpocetine, 250mg centrophenoxine and 500mg acetyl-l-carnitine). It turns out I am very sensitive to stimulants! That's probably because I stay far away from caffeine unless I am cutting down (rarely).

30 minutes after injesting I was so shakey I had to remind myself where I could find the poison control center phone number in case something bad happened. Don't laugh, I was serious! But I can't help but think that part of this was anxiety and/or placebo effect, because shouldn't the peak be at around 1 hour?

Anyway, I was running at 174 bpm right after my high intensity workout, about 1 hour 15 mins after injesting. Not too big of a deal. 2 hours after injesting I'm down to 93 bpm, and it just feels like a regular ECA stack now. Also, I injested on an empty stomach and didn't eat until 30 mins afterwards, which wasn't a good idea. I think I will lower the yohimbine to 3mg for a while and take advantage of my sensitivity, and take with food to slow absorption.

Thanks again for the help guys! I'd hate to know what Thermorexin would do to me...

 

[SlimJim300]

Hey, while this thread is open I have another question. Since yohimbine (when used alone) blocks the alpha2 receptor, could it actually improve insulin sensitivity when used on a low carb diet? I know insulin acts on the alpha2, but I don't know if that's where it "does it's thing". Then again, since you would have higher blood levels of norepinephrine because of lack of inhibition, this may negate itself. Just a curiosity!

 

[macrophage69alpha]

oral yohimbine has a very short half life.