Most efficent 1-AD intake?

[SlapItHard]

Im taking 600mg a day of 1-AD and about 300mg of Boldione. Currently consuming 3x200mg a day with meals, as evenly spaced out as possible. I eat a lot in between and was wondering if it would be more benificial to take 100mg every 2-3 hours totaling up to 600mg by the end of the day.

 

[Lumberg]

Of course it would be better. The more even the levels of androgen in your blood the better. You are also reducing the peak concentrations which should lead to less side effects.

JC

 

[pa1ad]

Of course it would be better. The more even the levels of androgen in your blood the better. You are also reducing the peak concentrations which should lead to less side effects.

JC

Its not neccessarily better.

You may not be aware of it but the oral bioavailabilty of prohormones goes up the higher the dosage you take. The liver cannot process high dosages well so more prohormone gets through intact (where it can undergo conversion efficiently in peripheral tissues). Conversely, lower dosages get chopped up pretty easily

Of course you want to balance the benefits of high dose bioavailablity with the benefits of multiple dose sustained blood levels. This is why 3 X 200mg is probably a good compromise

 

[Lumberg]

Its not neccessarily better.

You may not be aware of it but the oral bioavailabilty of prohormones goes up the higher the dosage you take. The liver cannot process high dosages well so more prohormone gets through intact (where it can undergo conversion efficiently in peripheral tissues). Conversely, lower dosages get chopped up pretty easily

Of course you want to balance the benefits of high dose bioavailablity with the benefits of multiple dose sustained blood levels. This is why 3 X 200mg is probably a good compromise

Wow. You learn something new every day. Thanks for the info.

But is this true for 1-AD? I thought it undergoes the change to 1-test at least partially in the liver.

Also, is there still an overpowering effect by combining PHs that are converted by different enzymes? In other words would combining 100mg 1AD with 200 mg androstenedione make more of the 1-AD convert to 1-test?

JC

 

[pa1ad]

Wow. You learn something new every day. Thanks for the info.

But is this true for 1-AD? I thought it undergoes the change to 1-test at least partially in the liver.

Also, is there still an overpowering effect by combining PHs that are converted by different enzymes? In other words would combining 100mg 1AD with 200 mg androstenedione make more of the 1-AD convert to 1-test?

JC

Its still true for 1-AD, however it may not be as vital with that as it is with less metabolic resistant steroids

Also, I don't think there is any convincing evidence that combining a diol with a dione results in any conversion benefits

 

[pa1ad]

You may not be aware of it but the oral bioavailabilty of prohormones goes up the higher the dosage you take. The liver cannot process high dosages well so more prohormone gets through intact (where it can undergo conversion efficiently in peripheral tissues). Conversely, lower dosages get chopped up pretty easily

this phenomenon was demonstrated quite clearly in an androstenedione study where they administered doses of 100mg and 300mg. The androstenedione levels in the blood after taking 300mg were something like 8 times as high (don't recall exactly) as seen after 100mg.

 

[SlapItHard]

I'm going to continue to take 200mg 3 times a day, and if I can't get any gear for my next cycle I will take 1-AD again and go 100mg 6 times a day. I am getting great results with my current intake though!

 

[Lumberg]

Pat,

Thanks for all the info.

I was wondering, now that the product has been out for a while do you have any good figures as far as oral bioavailability? The only figure I have seen is an estimate of 30% by Big Cat. Am I correct in believing that it is definitely higher than the commonly accepted 15% figure for other diols, which are converted by the same enzyme?

Also, in light of your comments, I have a more personal question:

I am currently on 400mg of 1-AD a day. I was originally doing 100 mg at breakfast, 200 mg lunch or postworkout, and 100mg at bedtime. Then when I heard it is better to have spread doses I split the middle dose into 100 mg post-w/o and another 100 mg later in the afternoon.

I was wondering, what is your recommendation for the dosage of 400 mg 1-AD per day? Should I go back to my original dosing scheme? Or maybe even switch to 200mg morning and night?

JC