I think milk thistle is a good supplement to take but I do agree that it dies not do near as well as ALA during a cycle. What most do not realize is that Milk Thistle strengthens the Liver by improving function and stimulating cell growth. When taken off-cycle it can be very effective in preparing your liver for any stress it might encounter from whatever source. Where people make their mistake is when they assume they will reap its benefits during a cycle and start the supplement when they start a cycle. It does not work that way. ALA does the trick for that approach. Both supplements are equal in effectiveness when used properly.