Let's talk oestrogen

[Nelson Montana]

My cortisol is good for morning cortisol, which is when it is at it's peak.

I have taken it in the afternoon when I was training hard, cycling 13 miles into work, on a comp diet, and my cortisol was lower than this.

I don't get to take birthcontrol as I have a clotting disorder, well at least the genes for it, I may clot too much, so doctors are reluctant to give it to me.

It isn't that much of an issue, there are other forms and methods of birth control.

If clotting is an issue (high platlets?) then steroids (even OTC) are out of the question for you anyway since they all tend to increase clotting.

 

[Tatyana]

If clotting is an issue (high platlets?) then steroids (even OTC) are out of the question for you anyway since they all tend to increase clotting.

I have the gene, I am homozygous, but from all the bloodwork I have done I don't express it.


What may be an issue is that won't be able to use HRT if and when I need it. Or it will be a bit of a battle.

I have a great GP though, he is really cool and keeps up with a lot of the current trends. He lets me do all my own blood work and always tells me that I know more about it than he does.







I have the gene, I am homozygous, but from all the bloodwork I have done I don't express it.

 

[jacshelb]

I believe Columbo in 81 was the first obvious case of it in competition. That signals the start of the "too high" dosage era.

Estro is easy to control. Keep it between 10 and 20 -- no higher, no lower, and you're cool.

Agreed.

This thread is actually making me re-think my decision to stop using a syno conversion for my prop. I see that the estrogen is controlled pretty easily and if it's not all bad.... hmmm... I may stick to something else pre-cycle for dieting though, less test (and clean test) with something like EQ. Interesting thread for sure.

 

[Tatyana]

If clotting is an issue (high platlets?) then steroids (even OTC) are out of the question for you anyway since they all tend to increase clotting.

I missed the high platelet thing, and no it isn't high platelets.

Coagulation is a really, really complicated cascade of enzyme reactions, platelets are just the end really. And there are two pathways of coagulation, intrinsic and extrinsic.

Do a google search, it is quite mind boggling.

I am homozygous (meaning both copies of my gene) have the mutation or defective polymorphism, for MTHFR or methylentetrahydrofolate reductase enzyme.

It is an enzyme involved in the processing of folate and the pentose phosphate pathway. It can also affect homocysteine metabolism.

The current treatment is high dose folate, B12 and B2.

I have done all sorts of blood work, my clotting times are normal, my homocysteine is normal, my folate levels are normal without supplementation.

It is thought that at least 10-30% of the population have this mutation, so it must confer some advantage somewhere. It is quite new-ish so most doctors and GPs are not entirely sure what to do about it.

This is something a lot of people don't understand about genetics.

Just because you have the mutation, it doesn't mean you will express the disease or disorder. This is referred to as penetrance. There are some mutations that have 100% penetrance, for example Huntington's. There are others that have a 50% penetrance.

There is also another genetic term called expressivity, which means not everyone will express the mutation in the same way.

For example, if you get the genetic pattern for polydactylism (mutltiple fingers and/or toes), they multiple fingers and toes do not look the same on everyone.

It may be that suffer no ill effect from it at all, it really does look that way right now, however, as this mutation is a part of my medical records, it does have to be considered in any medical treatment I have.

This is one of the issues with doing full genetic screens on people.

It is preferable to go with proteonomics, or the proteins produced by our genome, rather than the genomics, as they are not always directly related.