wow this thread really got interesting, LOL. I have been on 40mg of accutane for almost 2 months now, and am 2 weeks into a pretty heavy cycle, all injectables no orals, and so far my results have been awesome. My acne never got worse before getting better, it improved immediately and the only side i have gotten is slightly dry lips and my vision is a little blurry at times. Even for those that have mild acne that doesnt respond to all the BS OTC remedies, a low dose of this stuff will clear your ass right up. I havent had a new zit appear on my face since the first week of treatment, and ive had one or two on my face for 98% of my life since I was 15, Im almost 26 now and still got them almost everyday up until now. For those of you skeptical about taking it, I think the side effects are highly overrated at a dose of around 40mg/day. The horror stories you have heard are from people taking double that dosage.