For someone that has been in the game for so long I feel you are totally ignoring the positive evidence. I have never said the original study post at the beginning of this thread was the end all be all. In 2003 Columbia University published an article summarizing their study on the use of Clomid at 25mg/day to increase test levels. Pasted below is the pertinent information.
The Columbia study evaluated the use of clomiphene citrate tablets in 36 Caucasian men with hypogonadism, which was defined as a serum testosterone level < 300 ng/dl. Each patient received a daily dose of 25 mg of clomiphene citrate. The average patient age was 39 years, with 12 over age 40. The average pretreatment testosterone level was 247.6 ng/dl. All patients received the drug for at least three months; the entire group was followed for 1 year.
By the first follow-up visit, which occurred between four and six weeks of the start of therapy, the average testosterone level rose to 610 ng/dl, an increase of 146 percent compared with baseline. This response was seen in all patients regardless of age.
No patients reported any of the known side effects of clomiphene citrate, such as hot flashes, visual disturbances, or headaches. “In fact, most patients reported improvements in overall well-being, sex drive, physical strength, and mood on follow-up visit interviews. Some experienced these changes in as little as three months of therapy,” points out Dr. Fisch.
Perhaps you can clarify why the findings by doctors at Columbia university directly conflict with your claim that a dose of 25mg/day will actually make the situation worse.
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I would have to know why they were hypogonadal and how long their T levels remained elevated after the cessation of treatment. Two little factors that seem to be ignored.
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Again you are incorrect. A drug cannot be sold unless it has received FDA approval.
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No, it is you who are incorrect. Clomid was not originally approved for that purpose. So just because it's an "approved" drug does not mean it will work for something it isn't designed for. So it can be sold but that has nothing to do with what we're talking about. Acting imperious does not make you correct. You want to try that bullshit, go here:
www.bodybuilding.com
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This means the drug company has to show that
A. The drug is effective at treating medical issue in question (raising test in this case)
B. The side effects inccured by the usage of the drug are minimal
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36 men isn't much. I did a test on the effects of avenacosides on 25 men and that was out of pocket. The AMA couldn;t splurge for more than THAT?
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The average cost to bring a drug through the FDA for approval is around a billion dollars. The trans isomer of clomid, (normal clomid is both cis and trans) is currently in phase III trials. If you read the preliminary data from the phase I and II trials you will see that the response to this method has been overwhelmingly positive. So in reality there is an incredible amount of money invested in the idea that clomid can effectively restore test levels.
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Then why isn't it used as HRT? You can ague all day that it works, and it does in some people. But in others, it's a disaster. (Kinda like leeches). There are better ways. You can ignore them if you like, but they exist.