COKE and TEST

[Arabian]

http://www.mesomorphosis.com/articles/koert/testosterone-and-cocaine.htm


Article from above source.



Using Testosterone and Cocaine Together Cause Strokes
by Willem Koert, M.Sc.
http://www.ergogenics.org/

Many famous people believed to have "died" from steroids were also using recreational drugs, especially cocaine. An Italian experiment with blood platelets explains why the combination of steroids and cocaine can cause lethal strokes. "Coke" reinforces the dangerous qualities of testosterone and counteracts good ones.

The researchers performed two series of tests. First, they extracted blood platelets from the blood of healthy male subjects who were not using drugs or medicines. Then they exposed the platelets to moderately high concentrations of testosterone and cocaine. For purposes of this study, ‘moderately high’ means higher than you might find in the average male, but of the same magnitude physicians have found in anabolic-androgenic steroid users. The Italian researchers used testosterone in concentrations of 750 and 1500 nanomol. Physicians have found concentrations between 100 and 200 nanomol in heavy users.

Steroids can enhance platelet aggregation and cause blood clots, and coke has the same effects. But what happens when the two are combined? The figures below tell.

TXB2 is a stable and inactive metabolite of thromboxane A2 (TXA2). It is produced by blood platelets and causes vasoconstriction and platelet aggregation.



The figure below shows that the increased production of TXA2 actually resulted in more aggregation. LTb stands for the transparency of the samples. As a result of the aggregation the samples became more clear.



Both figures tell the same story. In contrast with predicted expectations, testosterone does not make your blood clot, and neither does coke. However, according to the Italian in vitro studies the chance of a stroke occurring starts to rise when the two drugs are combined.

The researchers don’t know how this works. All they know is that androgen receptors are not involved. Adding flutamide (a drug which blocks the androgen receptors) to the mixture had no effect.

Testosterone also has some direct beneficial effects on the arteries. The hormone causes vasorelaxation, which lowers blood pressure, increases blood flow and diminishes the chance of strokes. The Italian researchers discovered vasoconstruction doesn’t occur in the presence of cocaine when they exposed pieces of rabbit blood vessels to the testosterone-cocaine mixture. Once again though, the Italians are not sure how this works. Adding the anti-androgen flutamide had no effect.

In vitro is not in vivo. Nevertheless, the message is clear. The chances of a stroke as the result of testosterone administration alone are not very high, but the same cannot be said for cocaine and testosterone combined.

Source

Giuseppina Togna, Anna Rita Togna, Manuela Graziani, Matteo Franconi. Testosterone and cocaine: vascular toxicity of their concomitant abuse. Thrombosis Research, Volume 109, Issue 4 , 15 February 2003, Pages 195-201. [PubMed]

Agreed, Follow Solid Spines advice here and tell your friend that gear alone causes the heart to race and then doing coke, well thats stupid. He is increasing his chances of a heart attack two fold.

 

[justinjones1963]

coke mixes well with hot blondes who are STD free and like 3-sums...aside from that he needs to quit.

 

[FIGHTS]

I told him he's a fucking idiot. I'm so pissed at him right now. Its the 3rd times he's drank on his cycle and he's 3 weeks into it, and its the 1st time he did Coke. He's been smoking steady but went from a pack to 2-3 cigs a day. Now his ass has been up all night and takin the night off we are supposed to work out cuz he got fucked up. He was like " man I'm not doing that anymore..I'm breathing funny, and my heart is beating all fast" I was like "No fuck, you fucking idiot" Anyway...He say's he wont' do it again, but I think hearing some horror stories from ya'll or how much it lowers the amount of gains you can make will smack the last nail in. Thanks guys

 

[justinjones1963]

I told him he's a fucking idiot. I'm so pissed at him right now. Its the 3rd times he's drank on his cycle and he's 3 weeks into it, and its the 1st time he did Coke. He's been smoking steady but went from a pack to 2-3 cigs a day. Now his ass has been up all night and takin the night off we are supposed to work out cuz he got fucked up. He was like " man I'm not doing that anymore..I'm breathing funny, and my heart is beating all fast" I was like "No fuck, you fucking idiot" Anyway...He say's he wont' do it again, but I think hearing some horror stories from ya'll or how much it lowers the amount of gains you can make will smack the last nail in. Thanks guys

He definitely needs to quit. Refuse to lift with him etc. and cut him off if he doesn't quit. If you got other friends that know plan an intervention. A guy I graduated from high school OD'd a while back from heroin. Narcotics are no joke.

 

[BigCracker]

I don't like coke. I just like the way it smells.

I better cut back to an 8 ball a night then.

Boston George did 10 grams in 10 mins once-but he was natty. Boy George does coke too huh?

 

[glennds]

everyone jumps on their high horse whenever rec drugs are brought up, but my guess is AAS use and rec drug use not as mutually exclusive as you would think.

 

[DannoMight]

I had a buddy who decided to do a cycle and was a regular blow user. He j ust ended up having seizures/strokes a few months down the road. Nothin major.

 

[CO B-man]

alcohol is not that smart either really. it slows/retards and/or stops the synthesis of protien dependant on the individual for a few days. In other words you are wasting your time with gear and wasting gear for that matter since the reason you
inject it for is not going to happen a couple days after you drink. High bp and coke = deadly combination but hey, the world needs people to make an example of. Its only a matter of time that stuff will catch up to him.

 

[ninesecz]

yeh its always good to do something like coke that raises heart rate and then throw some steroids in the mix just for the extra kick to make sure he fuks himself up tell him i said good going with the white line 80 proof cycle HEY!!! why doesnt he just dd a little water to liqquify the coke and inject with the as?? seems like that would work good for him. my x girlfriends dad used to shoot coke like that.............before they dug a hole and buried him at 49 years old!!

 

[ninesecz]

yeh its always good to do something like coke that raises heart rate and then throw some steroids in the mix just for the extra kick to make sure he fuks himself up tell him i said good going with the white line 80 proof cycle HEY!!! why doesnt he just dd a little water to liqquify the coke and inject with the as?? seems like that would work good for him. my x girlfriends dad used to shoot coke like that.............before they dug a hole and buried him at 49 years old!!