Anyone ever tried Peyote or Mescaline?

[Lestat]

Samote, here is what I can find so for on the physical mechanism for tolerance to LSD:


Tolerance (defined as a decrease in responsiveness to a drug after repeated administration) to the behavioral effects of hallucinogens occurs in humans. At present, the precise mechanism of behavioral tolerance is unclear. In this study, we established a behavioral model of LSD tolerance and examined whether behavioral tolerance is related to altered serotonin receptor signaling. Rats were trained to discriminate 0.06 mg/kg LSD from saline in a two-lever drug discrimination paradigm. Two groups of animals were assigned to either chronic saline treatment or chronic LSD treatment. For chronic treatment, rats were injected s.c. once per day with either 130 g/kg LSD or saline for 5 days. Rats were tested on either saline or 0.06 mg/kg LSD, 24 hrs after the last chronic injection. Following chronic LSD treatment, the choice behavior of animals tested on LSD was reduced from 85% to 51% while no differences were found between the two groups tested on vehicle. In another group of rats receiving the identical chronic LSD paradigm, LSD (5 nM) stimulated [35S]GTPS binding, an index of G-protein coupling, was measured in rat brain by autoradiography. After chronic LSD, a significant reduction in LSD stimulated [35S]GTPS binding was observed in the medial prefrontal cortex (vehicle-treated; 81% above basal vs. LSD-treated; 40% above basal). These results indicate that adaptive changes in LSD stimulated serotonin receptor signaling may mediate behavioral tolerance to LSD.

http://sfn.scholarone.com/itin2003/...=126&abstract_id=13904&p_num=576.14&is_tech=0

 

[samoth]

See maybe I am just happy with the reality that I have with very little outside influence. But I have ALWAYS been shit scared to do any drug that would alter my perception of reality SO MUCH that I would lose all sense of reality right from the very moment it took effect.

I am VERY creative and satisfied with the sensations and interpretations that I have of MY REALITY pretty much the way I am with very little artificial enhancement.

If this means that I am vanilla....

*raises hand*

guilty as charged.

I just don't understand the need for such a feeling.... I am not putting anyone down for it. Seems silly if you ask me. And I told ya'll that since YOU DID ask me.

But if ya'll do, rock on. Just don't get behind the wheel of a car while I or any member of my family is on the road... m'kay? Then we will remain cool with one another.

I always found the effects of drugs on the human organism interesting, but I've never been impressed with any drug "high" I have experienced. The opiod class is well known, and I would have no interest in trying rec forms of this (I've already experienced many during a series of surgeries for a tumor in my head, lol). Similarly, I've never had any interest in pure psychadelics due to how much is unknown about them in medical science, and the ways that are known that the drugs work in the brain, I wouldn't touch them. PCP and ketamine always seemed interesting drugs to me, though, but I would not try them unless it was of a known or, for ket, pharmaceutically manufactured.

 

[Bikini Mod]

you are not vanilla, i don't think anyone NEEDS or SHOULD do drugs, its personal peference.

but when someone starts throwing out unfounded reasons for not wanting to do a drug, I question it.

For example, if you said, "I don't smoke weed because it will make my turn blue" I'd challenge that statement and ask you to show me why or how you came to believe this.

So if someone says "I'd never do a hallucinagenic because it don't wan't to be a loser" i'd also ask for some evidence or basis for the belief.

I never made either statement.

Stiletto's volunteered story about the window was more than enough illustration of why I am AFRAID to take such a drug. You lose ALL SENSE of reality. We are not talking a somewhat skewed perception. We are talking you have NO SENSE OF IT. You can look at her story from whatever angle you want, it will still illustrate MY FEAR to the *T*.

If you are NOT AFRAID, then rock on.

I am not ashamed to admit I am a chicken shit in this regard but do not say that MY FEAR is without foundation just because you do not feel it too.

 

[samoth]

Samote, here is what I can find so for on the physical mechanism for tolerance to LSD:


Tolerance (defined as a decrease in responsiveness to a drug after repeated administration) to the behavioral effects of hallucinogens occurs in humans. At present, the precise mechanism of behavioral tolerance is unclear. In this study, we established a behavioral model of LSD tolerance and examined whether behavioral tolerance is related to altered serotonin receptor signaling. Rats were trained to discriminate 0.06 mg/kg LSD from saline in a two-lever drug discrimination paradigm. Two groups of animals were assigned to either chronic saline treatment or chronic LSD treatment. For chronic treatment, rats were injected s.c. once per day with either 130 g/kg LSD or saline for 5 days. Rats were tested on either saline or 0.06 mg/kg LSD, 24 hrs after the last chronic injection. Following chronic LSD treatment, the choice behavior of animals tested on LSD was reduced from 85% to 51% while no differences were found between the two groups tested on vehicle. In another group of rats receiving the identical chronic LSD paradigm, LSD (5 nM) stimulated [35S]GTPS binding, an index of G-protein coupling, was measured in rat brain by autoradiography. After chronic LSD, a significant reduction in LSD stimulated [35S]GTPS binding was observed in the medial prefrontal cortex (vehicle-treated; 81% above basal vs. LSD-treated; 40% above basal). These results indicate that adaptive changes in LSD stimulated serotonin receptor signaling may mediate behavioral tolerance to LSD.

http://sfn.scholarone.com/itin2003/...=126&abstract_id=13904&p_num=576.14&is_tech=0

Interesting, but the psychadelic effects on the brain and higher reasoning centers of the human organism are not at a one-to-one correspondance with that of mice.

 

[stilleto]

a lot of people would never smoke pot. for lots of reasons.

but they would have a beer.

to me, that makes NO sense, but because one is commercialized and pushed on the public, and the other is illegal and frowned upon by some... it's what people believe to be the right order of things.

meanwhile, beer makes me lethargic, bloated, and lots of other things. weed calms me, i sleep great, and i wake up fine.

that's propaganda, for sure.

 

[stilleto]

is bmom the only one even reading my posts?

i'm going out. y'all suck.

 

[Bikini Mod]

I always found the effects of drugs on the human organism interesting, but I've never been impressed with any drug "high" I have experienced. The opiod class is well known, and I would have no interest in trying rec forms of this (I've already experienced many during a series of surgeries for a tumor in my head, lol). Similarly, I've never had any interest in pure psychadelics due to how much is unknown about them in medical science, and the ways that are known that the drugs work in the brain, I wouldn't touch them. PCP and ketamine always seemed interesting drugs to me, though, but I would not try them unless it was of a known or, for ket, pharmaceutically manufactured.

I suppose I am already fucked up enough and am satisfied to call it a day!

I'm a chicken shit pure and simple and not afraid to admit to it.

 

[samoth]

a lot of people would never smoke pot. for lots of reasons.

but they would have a beer.

to me, that makes NO sense, but because one is commercialized and pushed on the public, and the other is illegal and frowned upon by some... it's what people believe to be the right order of things.

meanwhile, beer makes me lethargic, bloated, and lots of other things. weed calms me, i sleep great, and i wake up fine.

that's propaganda, for sure.

Yep. It's all defined by society at any given time, for better or for worse.

 

[Lestat]

no, i think (and I could be wrong) what lestat is saying is that authority tells you that lsd for example is bad for you.

it's illegal, for one thing, plus there's so much press about the BAD things that can happen. but not a lot about the good things.

so you don't try it- ok. but you do... ride a motorcycle for example. something that I bet more people die from every year than lsd.

lestat, is that what you meant?

yes, pretty much.

I would venture to guess that LSD used to be completely legal, and given for for FREE for educational and research purposes. Many countries and institutions of higher education experimented with it.

Then in the 1960s it was very widely used in the US and linked to a "counterculture" scene.

This caused a huge religious backlash that coincided with the 1970s Born Again Christian movement. LSD was demonized.

Marijuana had the same thing. How many people today think that Marijuana causes brain damage? This was due to government propaganda that was based on ONE single primate study with 6-8 monkeys of which I believe half died and they had a mask with marijunana smoke inhaled 24 hours a day. The results were inconclusive, but one person spun it to prove that Marijuana causes brain damage.

Remember those "this is your brain, this is your brain on drugs" commercials? They were effective at making people believe that "drugs" are bad, but what drugs were they talking about? notice how those commercials never specified which ones???

Drugs have an effect on your brain, no doubt about it, what's why you take them, but do they DESTROY the brain when used in moderation? No evidence suggests this for Marijuana, and I'd love to see evidence that opiates destroy the brain, or that cocain does... those drugs have risks, but brain damage is the least of your concerns.

 

[Lestat]

a lot of people would never smoke pot. for lots of reasons.

but they would have a beer.

to me, that makes NO sense, but because one is commercialized and pushed on the public, and the other is illegal and frowned upon by some... it's what people believe to be the right order of things.

meanwhile, beer makes me lethargic, bloated, and lots of other things. weed calms me, i sleep great, and i wake up fine.

that's propaganda, for sure.

in this regard, we think alike.

samote, there are volumes of medical studies on LSD.

and today we do our cancer and AIDS research with Mice, you can win a nobel price with a rodent study, there is no reason to discount the lsd study based on the fact that it was mice alone.

We use pigeons for behavior studies too by the way.