My next poke I'm gonna use the 22's. Yesterday I used a 25, the problem is that it's so hard getting the test through the needle that I actually cause more pain because I'm squeezing the pusher so hard that I twist and bend the needle when it's inside of me, (fuckin hurts). So next time I'll "man up" and go for the smoother and easier transfer through the bigger but more intimidating 22.