The Glucosamine & Chondroitin never really did anything for me and niether did Cisus, and I am talking substantial doses of each.. But thats just me if it works for you then thats great. For me Adequan has been excellent. I did in fact notice some benefit from the very first injection. But where it really shines is at about the 3rd for me. And the nice thing about Adequan is that there are virtually no side effects as long as you dont dose too big. Also I get great relief from long term small doses of Deca. Am gonna try GHRP-6 per Radars post on here. My issues are shoulders, wear and tear. Knees, less then stellar genes.