Upstairs 58/60 during the day, 62/63 at night. Unless the kids and wife are out of town, then 58 max upstairs.
Downstairs stays at 64/65. With the basement @ 58.
It's always easier to warm up that it is to cool down in my house. And my 4 year old likes to be on the cool side.
I did get 50 free gallons of oil from a friend this year, so that makes it a bit easier to get by. We run a kerosene heater downstairs on days when it's below freezing outside. A few hours in the AM and then before bed really helps out.