UPDATE to 1.5 years and Still Shudown

[Jenetic]

Aromasin boosts Test?

Pharmacokinetics and Dose Finding of a Potent Aromatase Inhibitor, Aromasin (Exemestane), in Young Males

Nelly Mauras, John Lima, Deval Patel, Annie Rini, Enrico di Salle, Ambrose Kwok and Barbara Lippe

Suppression of estrogen, via estrogen receptor or aromatase blockade, is being investigated in the treatment of different conditions. Exemestane (Aromasin) is a potent and selective irreversible aromatase inhibitor. To characterize its suppression of estrogen and its pharmacokinetic (PK) properties in males, healthy eugonadal subjects (14–26 yr of age) were recruited. In a cross-over study, 12 were randomly assigned to 25 and 50 mg exemestane daily, orally, for 10 d with a 14-d washout period. Blood was withdrawn before and 24 h after the last dose of each treatment period. A PK study was performed (n = 10) using a 25-mg dose. Exemestane suppressed plasma estradiol comparably with either dose [25 mg, 38% (P 0.002); 50 mg, 32% (P 0.008)], with a reciprocal increase in testosterone concentrations (60% and 56%; P 0.003 for both). Plasma lipids and IGF-I concentrations were unaffected by treatment. The PK properties of the 25-mg dose showed the highest exemestane concentrations 1 h after administration, indicating rapid absorption. The terminal half-life was 8.9 h. Maximal estradiol suppression of 62 ± 14% was observed at 12 h. The drug was well tolerated. In conclusion, exemestane is a potent aromatase inhibitor in men and an alternative to the choice of available inhibitors. Long-term efficacy and safety will need further study.


Abbreviations: AUC, Area under the curve; CBC, cell blood count; HDL, high density lipoprotein; LDL, low density lipoprotein; PK, pharmacokinetic.

 

[b1ewsw32]

Pharmacokinetics and Dose Finding of a Potent Aromatase Inhibitor, Aromasin (Exemestane), in Young Males

Nelly Mauras, John Lima, Deval Patel, Annie Rini, Enrico di Salle, Ambrose Kwok and Barbara Lippe

Suppression of estrogen, via estrogen receptor or aromatase blockade, is being investigated in the treatment of different conditions. Exemestane (Aromasin) is a potent and selective irreversible aromatase inhibitor. To characterize its suppression of estrogen and its pharmacokinetic (PK) properties in males, healthy eugonadal subjects (14–26 yr of age) were recruited. In a cross-over study, 12 were randomly assigned to 25 and 50 mg exemestane daily, orally, for 10 d with a 14-d washout period. Blood was withdrawn before and 24 h after the last dose of each treatment period. A PK study was performed (n = 10) using a 25-mg dose. Exemestane suppressed plasma estradiol comparably with either dose [25 mg, 38% (P 0.002); 50 mg, 32% (P 0.008)], with a reciprocal increase in testosterone concentrations (60% and 56%; P 0.003 for both). Plasma lipids and IGF-I concentrations were unaffected by treatment. The PK properties of the 25-mg dose showed the highest exemestane concentrations 1 h after administration, indicating rapid absorption. The terminal half-life was 8.9 h. Maximal estradiol suppression of 62 ± 14% was observed at 12 h. The drug was well tolerated. In conclusion, exemestane is a potent aromatase inhibitor in men and an alternative to the choice of available inhibitors. Long-term efficacy and safety will need further study.


Abbreviations: AUC, Area under the curve; CBC, cell blood count; HDL, high density lipoprotein; LDL, low density lipoprotein; PK, pharmacokinetic.

Excellent post J...Why was there less suppresion of E and less testosterone increases from the higher 50mg. dose?

This validates the safety issues I had with exemestane having possible permanent E suppresion. Plus the mean-elimination half-life of 8.9hrs is cofortable in case one needs to bail out, howerver time for development of new enzymes via the cyp 10 gene is unknown and follow-ups and further investigations need to be performed.

Btw..been a bit busy, but will contribute to your pct thread asap.

Peace...B32

 

[psychedout]

The treatment has been going fantastic. My strength and endurance is significantly increasing every week. It's funny because it looks like I am making gains that a cycle would give me. No supplements involved including protein shakes. Only solid foods. I finally have what it takes again to sustain a full blown workout.

Kinda off topic for this thread -- but do you have something against shakes?

Just curious. I can say that when I diet, I usually discard shakes as a protein source -- it just feels better (I know that hardly qualifies as being scientific LOL); however while trying to add mass, its not uncommon for me to have 6-10 scoops of whey per day.

So whats your 2 cents on shakes?

 

[Jenetic]

Kinda off topic for this thread -- but do you have something against shakes?

Just curious. I can say that when I diet, I usually discard shakes as a protein source -- it just feels better (I know that hardly qualifies as being scientific LOL); however while trying to add mass, its not uncommon for me to have 6-10 scoops of whey per day.

So whats your 2 cents on shakes?

I have nothing against shakes. It's considered a nutritional supplement. If I didn't have sufficient intake with my diet, I would add it in. Currently, my caloric needs are not that high, I prefer to eat whole foods and I'm in a country where they charge $100 for a bottle of name brand protein.

Jenetic

 

[Jenetic]

As a final update, I have finished my recovery treatment and my testosterone is back to 872. This blood test was taken 4 weeks after cessation of gonadotropin therapy.

Jenetic

 

[bigbair]

Congratulations. I'm having by Bloodwork done in about a week.

 

[Mr. Black]

As a final update, I have finished my recovery treatment and my testosterone is back to 872. This blood test was taken 4 weeks after cessation of gonadotropin therapy.

Jenetic

872 is quite high. Good shit What did your other levels normalize at?(free test, prolactin, estradiol..) Also would you mind detailing your complete recovery process from weeks 1- x?

 

[adam wj]

As a final update, I have finished my recovery treatment and my testosterone is back to 872. This blood test was taken 4 weeks after cessation of gonadotropin therapy.

Jenetic

fucker

lets hope mine comes back around there

 

[Smokescreen]

As a final update, I have finished my recovery treatment and my testosterone is back to 872. This blood test was taken 4 weeks after cessation of gonadotropin therapy.

Jenetic

Question is...do you plan on juicing again? Because if do, it really didn't make much sense in bringing your own test up. For what? To screw it up all over again? Get back to me on this. I would like to hear from you on this. Remember Jenetic...both you and I have the same problem. But mine has a solution.

 

[adam wj]

what problem is that?