Tyelenol's effect on gains: myth or any science behind it?

[LoneTree]

1: Am J Physiol Endocrinol Metab. 2002 Mar;282(3):E551-6. Links
Effect of ibuprofen and acetaminophen on postexercise muscle protein synthesis.Trappe TA, White F, Lambert CP, Cesar D, Hellerstein M, Evans WJ.
Donald W. Reynolds Center on Aging, Department of Geriatrics, University of Arkansas for Medical Sciences, and the Central Arkansas Veterans HealthCare System, Little Rock, Arkansas 72205, USA. [email protected]

We examined the effect of two commonly consumed over-the-counter analgesics, ibuprofen and acetaminophen, on muscle protein synthesis and soreness after high-intensity eccentric resistance exercise. Twenty-four males (25 +/- 3 yr, 180 +/- 6 cm, 81 +/- 6 kg, and 17 +/- 8% body fat) were assigned to one of three groups that received either the maximal over-the-counter dose of ibuprofen (IBU; 1,200 mg/day), acetaminophen (ACET; 4,000 mg/day), or a placebo (PLA) after 10-14 sets of 10 eccentric repetitions at 120% of concentric one-repetition maximum with the knee extensors. Postexercise (24 h) skeletal muscle fractional synthesis rate (FSR) was increased 76 +/- 19% (P < 0.05) in PLA (0.058 +/- 0.012%/h) and was unchanged (P > 0.05) in IBU (35 +/- 21%; 0.021 +/- 0.014%/h) and ACET (22 +/- 23%; 0.010 +/- 0.019%/h). Neither drug had any influence on whole body protein breakdown, as measured by rate of phenylalanine appearance, on serum creatine kinase, or on rating of perceived muscle soreness compared with PLA. These results suggest that over-the-counter doses of both ibuprofen and acetaminophen suppress the protein synthesis response in skeletal muscle after eccentric resistance exercise. Thus these two analgesics may work through a common mechanism to influence protein metabolism in skeletal muscle.

Good article. Thanks.
Unfortunately, once again: no pain, no gain.

 

[GoldenDelicious]

pharmacist

with difficult questions like this, imo you should step back and use common sense.

old people take a lot of painkillers. old people losing weight is a really REALLY bad thing. there has never been any significant concern expressed in the mainstream literature about even reduced painkiller use even being considered as part of therapeutic choice.

imo it isnt myth, there is obviously science, but is of little consequence. then when you factor inthe morbidity (in your case, pain, reduced gym intensity etc) associated with not using it, (and potential co conditions, joint wear etc)you decidek that using the drug is by far the best option.

 

[redsamurai]

ice works better than anything IMO......does anyone know where you can get those ice jackets you see pitchers or quarterbacks wearing after a game? The only problem with ICE is it's a pain in the ass......and usually the bag starts leaking all over you after a while. But those harnesses used by pro athletes look like they keep everything together. I stay away from painkillers unless I"m having back problems...than I have no choice, and I'm certainly not lifting weights when I can barely walk.....so no problem there.

 

[workout1960]

kudos to the aussie. smart man.

 

[macrophage69alpha]

pain killer use is often beneficial or necessary, however the impact should be considered and dosing minimized where possible. (the effect does appear to be dose dependant)

 

[LoneTree]

This is the picture:
The reults of the study cannot be applied universally.

By itself, the results are not reliable at all. The statistical analysis is complete bullshit. There are no confidence intervals mentioned for any data, and the raw numbers are all over the place. The P value for ibuprofen/acetaminophen group is more than 0.05.

They checked protein synthesis at one time, 24 hours after exercise. Protein synthesis in the muscle is a continuous process. You can not extrapolate it that there was no protein synthesis at all.

This study only raises a question. Acetaminophen 'MAY' decrease protein synthesis after exercise. If you are using AAS, then this may not be applicable at all.

I would disagree with one opinion mentioned. If it decreases protein synthesis AFTER EXERCISE, it does not automatically mean it will cause protein/muscle loss if you don't exercise. It would be oversimplification of a very complex and not very well understood process.

I decided not to take tyelenol because I can handle the pain. On the other hand if the pain is interferring with your workout, probably you are better off taking it (preferably tyelenol/acetaminophen instead of NSAIDs).

 

[zk7]

ITS TYLENOL not TYELELELENOL

Secondly, eating Tylenol like candy IS THE STUPIDIEST thing i heard from anyone. That shit can cause serious liver damage, max is 8 caps (500mg/cap) within 24 hour period, even then thats pushing it.

And yea its OTC, lots of OTC things can kill you, that doesnt mean society is nuts for making roids illegal. So stop comparing apple and oranges.

And stop comparing roids with tylenol Or cigarettes with other drugs.

Laws are like that, period. theres entire industries and lobby and bunch of stuff making the law the way it is, your a citizen and your job is to obey the law like a good slave.

thats what it is basically.

 

[macrophage69alpha]

I would disagree with one opinion mentioned. If it decreases protein synthesis AFTER EXERCISE, it does not automatically mean it will cause protein/muscle loss if you don't exercise. It would be oversimplification of a very complex and not very well understood process.

actually the study clearly states that it does not cause protein LOSS, but that it does decrease protein synthesis. So they MAY inhibit GAINS to some extent.

 

[zk7]

And actually just because a Study says something, that means diddly squat. Studies are biased, funded by parties who stand to benefit from such studies. Most of the information online is biased and potentially hogwash.

 

[LoneTree]

actually the study clearly states that it does not cause protein LOSS, but that it does decrease protein synthesis. So they MAY inhibit GAINS to some extent.

I agree. Study didn't mention protein loss. It was a post in this thread that mentioned it.