I've ran tren ace ED & EoD and noticed no difference. I've ran tren-a about 6 times and always had the same sides whether I ran ED or EoD, sleeplessness, night sweats, wide awake amphetamine affect, and tren dick if used over 8 weeks.
However, my friend who is 265lb ifbb pro body builder says that tren-e has MUCH less sides and can be ran longer. I think I'd take his word for it.