I have a coworker that these 2 phrases get him everytime no matter what he is talking about or saying, I interupt him and reply in a loud voice one of the 2 phrases.
"Have you ever kissed a girl?" or "Will you please just stop talking?"
He gets so mad he can't think straight and proceeds to make a total ass of himself everytime. I swear, you think he would learn but we are going on 2 years now and he falls for it about once a week. What a tool.