How big is this town?
What is the climate, ie seasonal, always hot, always cold. Do any tourists pass by etc.
If it's strictly just a college town, any business will be tough. By nature, college kids are not flushed with cash. Any business that just relies on college kids for survival will do it tough.
You want a business with low capital costs. ie a fitout on a bar or cafe can cost anywhere upwards of $100,000, which will be impossible to recoup if it doesn't go well.
Give me more of an idea on the make-up of the town and i can come up with some other ideas